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11.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators 有权四氢吡啶 - 吡啶和四氢吡啶 - 嘧啶化合物及其作为C5a受体调节剂的用途公开(公告)号：US08846656B2
公开(公告)日：2014-09-30
申请号：US13553120
申请日：2012-07-19
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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12.发明授权公开(公告)号：US08673974B2
公开(公告)日：2014-03-18
申请号：US13294262
申请日：2011-11-11
IPC分类号： A01N37/10
CPC分类号： C07C235/74
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, X, X1, s and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，A1，X，X1，s和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供本发明化合物的药物组合物和药理活性剂与本发明化合物的组合。
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公开(公告)号：US08263629B2
公开(公告)日：2012-09-11
申请号：US12788794
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/41 , C07D271/04 , C07D271/06 , C07D271/08 , C07D271/10 , C07D263/30 , C07D261/06 , C07D257/02
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20100305145A1
公开(公告)日：2010-12-02
申请号：US12788794
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/505
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20100305131A1
公开(公告)日：2010-12-02
申请号：US12788766
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/5375 , C07C235/74 , A61K31/24 , C07D317/40 , A61K31/365 , C07D295/15 , C07C255/60 , C07D239/28 , A61K31/275 , A61K31/505 , C07D239/36 , C07D213/82 , A61K31/44 , C07D309/40 , A61K31/351 , C07D239/42 , C07D213/56 , A61K31/4402 , C07D235/16 , A61K31/4184 , C07D207/16 , A61K31/40 , C07D263/38 , A61K31/421 , C07D277/56 , A61K31/426 , C07D271/113 , A61K31/4245 , C07D257/04 , A61K31/41 , C07D237/24 , A61K31/50 , A61K31/195 , A61P3/04 , A61P9/12 , A61P9/00 , A61P13/12 , A61P15/00 , A61P3/10 , A61P9/10 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/18 , A61P35/02 , A61P25/24 , A61P1/00 , A61P17/02 , A61P27/06
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。 本发明还涉及制备本发明化合物及其治疗用途的方法。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US08877815B2
公开(公告)日：2014-11-04
申请号：US13293560
申请日：2011-11-10
申请人： Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Qian Liu , Muneto Mogi , Nikolaus Schiering , Robert Sun
发明人： Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Qian Liu , Muneto Mogi , Nikolaus Schiering , Robert Sun
IPC分类号： A61K31/165 , C07D295/185 , C07C237/22 , C07D257/04 , C07D307/52 , C07C233/63 , C07D213/55 , C07C233/52 , C07D471/04 , C07D207/16
CPC分类号： C07C233/52 , C07C233/63 , C07C237/22 , C07C2601/08 , C07D207/16 , C07D213/55 , C07D257/04 , C07D295/185 , C07D307/52 , C07D471/04
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，B，X，m和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供了本发明化合物的药物组合物，以及药理活性剂和本发明化合物的组合。
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公开(公告)号：US08697739B2
公开(公告)日：2014-04-15
申请号：US13189760
申请日：2011-07-25
申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su
IPC分类号： C07D215/00 , C07D235/04 , A61K31/4985 , A61K31/47
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。 本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。
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公开(公告)号：US20120252830A1
公开(公告)日：2012-10-04
申请号：US13490562
申请日：2012-06-07
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/197 , C07C235/74 , C07C235/12 , C07C235/82 , C07D303/46 , A61K31/336 , C07D307/68 , A61K31/341 , C07D333/38 , A61K31/381 , C07D213/81 , A61K31/44 , C07D239/28 , A61K31/505 , C07D231/14 , A61K31/415 , C07D207/34 , A61K31/40 , C07D233/90 , A61K31/4164 , C07D211/60 , A61K31/445 , C07D239/42 , C07D239/36 , A61P7/10 , A61P3/10 , A61P3/04 , A61P9/12 , A61P9/00 , A61P13/12 , A61P17/00 , A61P9/10 , A61P9/06 , A61P27/06 , A61P15/00 , A61P15/06 , A61P11/06 , A61P29/00 , A61P35/02 , A61P25/08 , A61P25/24 , A61P25/18 , A61P25/28 , A61P1/00 , A61P17/02 , A61P3/00 , C07C235/84
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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19.发明申请Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof 审中-公开氨基甲基 - 二芳基衍生物补体因子D抑制剂及其用途公开(公告)号：US20160145247A1
公开(公告)日：2016-05-26
申请号：US14904693
申请日：2014-07-17
申请人： David B. BELANGER , Stefanie FLOHR , Christine Fang GELIN , Keith JENDZA , Nan JI , Donglei LIU , Edwige Lilliane Jeanne LORTHIOIS , Rakeshri Ganesh KARKI , Nello MAINOLFI , James J. POWERS , Stefan Andreas RANDL , Olivier ROGEL , Anna VULPETTI , Taeyoung YOON
发明人： David Belanger , Stefanie Flohr , Christine Fang Gelin , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Donglei Liu , Edwoge Liliane Jeanne LORTHIOIS , Nello Mainolfi , James J. Powers , Stefan Andreas Randi , Oliver Rogel , Anna Vulpetti , Taeyoung YOON
IPC分类号： C07D417/12 , C07C237/42 , C07D263/32 , C07D213/56 , C07D231/12 , C07D307/16 , C07D213/81 , C07D277/56 , C07D213/82 , C07D233/90 , C07D405/12 , C07C311/37 , C07D239/26 , C07D309/14 , C07D309/06 , C07C229/34 , C07D311/42 , C07D317/60 , C07D231/56 , C07D257/04 , C07D265/30 , C07D267/10 , C07D215/12 , C07D205/04 , C07D305/06 , C07C237/40
CPC分类号： C07D417/12 , C07C217/48 , C07C217/58 , C07C217/64 , C07C217/74 , C07C217/76 , C07C229/34 , C07C229/36 , C07C229/42 , C07C233/43 , C07C233/47 , C07C233/63 , C07C235/34 , C07C235/46 , C07C237/20 , C07C237/38 , C07C237/40 , C07C237/42 , C07C255/16 , C07C255/43 , C07C255/57 , C07C255/59 , C07C257/18 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D205/04 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/90 , C07D239/26 , C07D257/04 , C07D263/32 , C07D265/30 , C07D267/10 , C07D277/56 , C07D305/06 , C07D307/16 , C07D309/06 , C07D309/14 , C07D311/42 , C07D317/60 , C07D405/12
摘要： The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供了式（I）化合物，本发明化合物的制备方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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