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    Culture device having a detachable cell or tissue growth surface
    13.
    发明授权
    Culture device having a detachable cell or tissue growth surface 失效
    具有可分离细胞或组织生长表面的培养装置

    公开(公告)号：US5139951A

    公开(公告)日：1992-08-18

    申请号：US595305

    申请日：1990-10-10

    Applicant: David Butz ,  George Lyman ,  David Root ,  Gregory Mathus

    Inventor： David Butz ,  George Lyman ,  David Root ,  Gregory Mathus

    IPC: C12M3/06

    CPC classification number: C12M25/02 ,  C12M23/00 ,  C12M23/12

    Abstract: A tissue or cell growth device is described for placement within a well of a cluster dish. The device has a cell or tissue retention element detachably attached to a hanger. The hanger preferably has openings allowing access to the well without removal of the member and is capable of positioning the cell or tissue retention element a preselected distance relative to the hanger. Also described are various embodiments of the device having differently shaped hangers and the combination of the device and a cluster dish.

    Abstract translation: 描述了组织或细胞生长装置用于放置在簇盘的孔内。 该装置具有可拆卸地附接到衣架的细胞或组织保持元件。 衣架优选地具有允许进入井的开口，而不移除构件，并且能够将电池或组织保持元件相对于衣架定位成预选的距离。 还描述了具有不同形状的悬挂器以及装置和簇盘的组合的装置的各种实施例。

    Apparatus for growing tissue cultures in vitro
    14.
    发明授权
    Apparatus for growing tissue cultures in vitro 失效
    用于体外培养组织培养物的装置

    公开(公告)号：US5026649A

    公开(公告)日：1991-06-25

    申请号：US841562

    申请日：1986-03-20

    Applicant: George Lyman ,  Gregory Mathus ,  David Root

    Inventor： George Lyman ,  Gregory Mathus ,  David Root

    IPC: C12M1/20 ,  C12M1/22 ,  C12M3/00 ,  C12M3/06

    CPC classification number: C12M29/04 ,  C12M25/04

    Abstract: Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a tubular support that in turn hangs by a flange connected to its upper end on the top of a well containing the nutrients. Typically, the well is part of a tissue culture cluster dish. The flange of the support positions the support and membrane centrally in the well so as to avoid capillary action in the space between the well and support. The configuration of the support and its cooperation with the lid of the cluster dish also prevents the support and membrane from floating in the nutrient solution in the well. Openings in the support provide access for a pipette to add and withdraw fluid from the space between the well and membrane support and from the space below the membrane.

    Abstract translation: 用于在体外生长组织培养物的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜发育。 可渗透膜附接到管状支撑件的底端，管状支撑件的底端又通过连接到容纳营养物质的孔的顶部上方的凸缘而悬挂。 通常，孔是组织培养簇盘的一部分。 支撑件的凸缘将支撑件和膜中心定位在井中，以避免在井和支撑件之间的空间中的毛细作用。 支架的配置及其与簇盘盖的配合也可防止支撑和膜浮在井中的营养液中。 支架中的开口提供移液管的通道，以从孔和膜支撑之间的空间以及膜下方的空间添加和抽出流体。

    Substrates for Isolating, Reacting and Microscopically Analyzing Materials
    15.
    发明申请
    Substrates for Isolating, Reacting and Microscopically Analyzing Materials 审中-公开
    用于隔离，反应和显微分析材料的基板

    公开(公告)号：US20100311614A1

    公开(公告)日：2010-12-09

    申请号：US12815832

    申请日：2010-06-15

    Applicant: Jean I. Montagu ,  Roger Dowd ,  David Root

    Inventor： Jean I. Montagu ,  Roger Dowd ,  David Root

    IPC: C40B40/02 ,  B05D3/06 ,  B05D3/02 ,  B05D1/18 ,  C40B40/00 ,  C40B40/06 ,  C40B40/08 ,  C40B40/10

    CPC classification number: G01N33/544 ,  G01N33/54366

    Abstract: An immobilizing device for biological material comprises a rigid support (12) carrying a substrate layer (20, 20′) of polymer having biological immobilizing properties, e.g. for amino and nucleic acids. Substantially solid ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably between about 0.1 and 0.5 micron, and microporous, ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably less than 3 micron, 2 or 1 micron are shown, which may be segmented by isolating moats M. The substrate layer is on a microscope slide (302), round disc (122), bio-cassette, at the bottom of a well of a multiwell plate, and as a coating inside a tube. Fluorescence or luminescence intensity and geometric calibration spots (420) are shown. Reading is enhanced by the intensity calibration spots (420) to enable normalization of readings under uneven illumination conditions, as when reading by dark field, side illumination mode. The reference spots are shown being printed simultaneously with printing an array of biological spots or with the same equipment. Methods of forming layers of the device include controlled drawing from a bath of coating composition and drying, and spinning of C-D shaped substrates. Post-forming treatment is shown by corona treatment and radiation. Adherent metal oxides (14), silica-based materials and other materials are used to unite layers of the composite. In multiwell plates the oxide promotes joining of a bottom plate (95, 95′) and upper, well-defining structure (94) of dissimilar material. The oxides (14) also provide beneficial opacity to prevent light entering the glass support, for applying potential to the substrate, etc.

    Abstract translation: 用于生物材料的固定装置包括承载具有生物固定性质的聚合物的基底层（20,20'）的刚性支撑体（12），例如。 用于氨基和核酸。 具有厚度小于约5微米，优选约0.1至0.5微米的基本上固体的超薄基底层（20'）和厚度小于约5微米的微孔，超薄基底层（20'），优选地 示出了小于3微米，2或1微米，其可以通过分离护羊M分段。基底层在显微镜载玻片（302），圆盘（122），生物盒，在孔的底部 多孔板，以及管内的涂层。 显示荧光或发光强度和几何校准点（420）。 通过强度校准点（420）增强读数，以使得在不均匀照射条件下的读数正常化，如通过暗场，侧面照明模式读取。 参考点被显示为同时印刷生物斑点阵列或用相同的设备打印。 形成装置层的方法包括从涂料组合物的浴中进行控制拉伸和干燥，以及C-D形基材的纺丝。 后处理通过电晕处理和辐射显示。 使用粘附金属氧化物（14），二氧化硅基材料和其他材料来组合复合材料层。 在多孔板中，氧化物促进底板（95,95'）和不同材料的上部，良好限定结构（94）的接合。 氧化物（14）还提供有益的不透明性，以防止光进入玻璃支撑体，以将电位施加到基底等。

    Multi-well filter strip and composite assemblies
    18.
    发明授权
    Multi-well filter strip and composite assemblies 失效
    多孔过滤条和复合组件

    公开(公告)号：US4948564A

    公开(公告)日：1990-08-14

    申请号：US430812

    申请日：1989-11-02

    Applicant: David Root ,  George Lyman

    Inventor： David Root ,  George Lyman

    IPC: B01D29/01 ,  B01D61/18 ,  B01L3/00 ,  B01L9/06 ,  G01N21/03

    CPC classification number: B01L9/06 ,  B01D61/18 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/50855 ,  G01N2021/0357 ,  G01N2201/0446 ,  Y10S436/809 ,  Y10T436/255

    Abstract: A filter strip and composite assemblies for filtering microliter quantities of fluids. A linear array of wells having open top and bottom ends are connected by frangible webs in spaced-apart relation with discrete filter membranes closing the bottom ends of each well. Tabs are provided on the ends of the filter strip for holding the same and supporting the strip in a rectangular holder having alpha-numeric designations for identifying each well in a plurality of such filter strips contained within the holder. The filter strip may be used in a vacuum manifold for applying a pressure differential across the filter membrane and directing the filtrate into an aligned aperture of a closed bottom well of an array of wells held within the manifold. Alternatively, the filter strip may be used with a transfer plate for directing the filtrate from each well of the filter strip to an aligned well of a closed bottom array of wells. Another composite assembly includes a pressure manifold for applying an increased pressure above the membranes.

    Abstract translation: 用于过滤微量流体的过滤条和复合组件。 具有开放的顶部和底部的井的线性阵列通过易碎的腹板以间隔开的关系连接，离心过滤膜封闭每个孔的底端。 在过滤条的端部设置有用于保持其的突片，并将条带支撑在具有字母数字标号的矩形保持器中，用于识别容纳在保持器内的多个这种过滤条中的每个孔。 过滤条可以用在真空歧管中，用于在过滤膜上施加压力差，并将滤液引导到保持在歧管内的阱阵列的封闭的底部井的对准孔。 或者，过滤条可以与转移板一起使用，用于将滤液从过滤条的每个孔导向孔的封闭底部阵列的对准井。 另一复合组件包括用于在膜上施加增加压力的压力歧管。

    Ruggedized composite rack mount transport case
    19.
    发明授权
    Ruggedized composite rack mount transport case 失效
    坚固的复合机架安装运输箱

    公开(公告)号：US08413833B1

    公开(公告)日：2013-04-09

    申请号：US13089929

    申请日：2011-04-19

    Applicant: Alan Taylor ,  David Root

    Inventor： Alan Taylor ,  David Root

    IPC: B65D45/00 ,  B65D51/12 ,  B65D45/32 ,  B65D6/00

    CPC classification number: H05K5/061 ,  H05K5/0221

    Abstract: A ruggedized case for transportation and protection of electronic equipment used in harsh commercial or military environments. The ruggedized case is 30-70% lighter than other similar competing cases through the use of lightweight, low-density, superior strength composite materials. The ruggedized case includes a multi-panel case body open at each end and two removable covers. A chassis which may be vibration and shock isolated, and a removable rack mount frame are also provided. Each component of this ruggedized case, including recessed cover latches, and handles, weather and airtight seals, adjustable rack mount frame lock mechanisms, and vibration isolators, have been significantly improved to provide more ergonomic form and functionality.

    Abstract translation: 用于运输和保护恶劣商业或军事环境中使用的电子设备的坚固耐用的案例。 通过使用轻质，低密度，优异的强度复合材料，坚固耐用的外壳比其他类似的竞争对手轻30-70％。 坚固耐用的外壳包括在每个端部打开的多面板外壳主体和两个可拆卸盖。 还提供了可能是振动和冲击隔离的底盘以及可拆卸的机架安装架。 这种坚固耐用的外壳的每个部件，包括凹槽盖锁和手柄，天气和气密密封，可调节的机架安装框架锁定机构和隔振器已经得到显着改善，以提供更符合人体工程学的形式和功能。

    Substrates For Isolating, Reacting And Microscopically Analyzing Materials
    20.
    发明申请
    Substrates For Isolating, Reacting And Microscopically Analyzing Materials 审中-公开
    用于隔离，反应和显微分析材料的基板

    公开(公告)号：US20120129713A1

    公开(公告)日：2012-05-24

    申请号：US13272980

    申请日：2011-10-13

    Applicant: Jean I. Montagu ,  Roger Dowd ,  David Root

    Inventor： Jean I. Montagu ,  Roger Dowd ,  David Root

    IPC: C40B30/04 ,  B05D1/36 ,  C40B60/12 ,  B05D1/18

    CPC classification number: G01N33/544 ,  G01N33/54366

    Abstract: An immobilizing device for biological material comprises a rigid support (12) carrying a substrate layer (20, 20′) of polymer having biological immobilizing properties, e.g. for amino and nucleic acids. Substantially solid ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably between about 0.1 and 0.5 micron, and micro-porous, ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably less than 3 micron, 2 or 1 micron are shown, which may be segmented by isolating moats M. The substrate layer is on a microscope slide (302), round disc (122), bio-cassette, at the bottom of a well of a multiwell plate, and as a coating inside a tube.

    Abstract translation: 用于生物材料的固定装置包括承载具有生物固定性质的聚合物的基底层（20,20'）的刚性支撑体（12），例如。 用于氨基和核酸。 具有厚度小于约5微米，优选约0.1至0.5微米的基本上固体的超薄基底层（20'）和厚度小于约5微米的微孔超薄基底层（20'） ，优选小于3微米，2或1微米，其可以通过分离护羊M分段。基底层在显微镜载玻片（302），圆盘（122），生物盒，底部 多孔板，以及管内的涂层。

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