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公开(公告)号：US10118174B2
公开(公告)日：2018-11-06
申请号：US15825689
申请日：2017-11-29
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
IPC: B01L3/00 , B01F5/06 , B01F13/00 , B01J19/00 , G01N35/08 , C12P19/34 , C12Q1/44 , B01F3/08 , B01L7/00 , B82Y30/00 , G01N15/14 , B01F5/04
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20180304268A1
公开(公告)日：2018-10-25
申请号：US15926988
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
CPC classification number: B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20180272352A1
公开(公告)日：2018-09-27
申请号：US15926992
申请日：2018-03-20
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US10054961B2
公开(公告)日：2018-08-21
申请号：US14184312
申请日：2014-02-19
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC: B01J19/00 , G01N1/38 , G01N35/10 , G05D7/06 , G01N35/08 , B01F13/00 , B01F5/04 , B01L3/02 , B01L3/00
CPC classification number: G05D7/0694 , B01F5/0471 , B01F13/0071 , B01J19/0046 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/0293 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N35/08 , G01N2035/1034 , Y10T137/0318
Abstract: The present invention provides manipulation of spacing between microdroplets flowing in a microfluidic system. The manipulation includes increasing and/or decreasing spacing between a pair of adjacent droplets of a sample fluid flowing in an immiscible carrier fluid within a main microfluidic channel. The main microfluidic channel includes a region having one or more side branch channels. The spacing between the pair of droplets flowing through the region can be increased or reduced with either the addition of or removal of immiscible carrier fluid between the adjacent droplets via at least one of the side branch channels, wherein the pair of droplets remain intact while flowing through the region and continue to flow within the main microfluidic channel downstream of the region.
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公开(公告)号：US20180193838A1
公开(公告)日：2018-07-12
申请号：US15861225
申请日：2018-01-03
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
IPC: B01L3/00 , C12Q1/44 , B01F3/08 , B01F5/06 , B01F13/00 , C12P19/34 , B01J19/00 , G01N15/14 , G01N35/08 , B01L7/00 , B82Y30/00
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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Patent Agency Ranking
公开(公告)号：US09968933B2
公开(公告)日：2018-05-15
申请号：US15673955
申请日：2017-08-10
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song Baca , Lewis Spencer Roach
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US09839893B2
公开(公告)日：2017-12-12
申请号：US14836432
申请日：2015-08-26
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song , Lewis Spencer Roach
IPC: B01L3/00 , B01J19/00 , B01F5/06 , B01F13/00 , G01N35/08 , C12P19/34 , C12Q1/44 , B82Y30/00 , G01N15/14
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20160288124A1
公开(公告)日：2016-10-06
申请号：US15087176
申请日：2016-03-31
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Cory John Gerdts , Bo Zheng
CPC classification number: B01L3/502784 , B01D9/0072 , B01D2009/0086 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01J14/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00894 , B01J2219/00903 , B01J2219/00975 , B01J2219/00977 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2200/12 , B01L2300/0867 , B01L2400/0487 , B82Y30/00 , C07K14/43 , C12N9/2462 , C12Q1/6806 , C12Y302/01017 , C30B7/14 , C30B29/54 , C30B29/58 , G01N1/28 , G01N35/08 , Y10T117/10 , Y10T137/0318 , Y10T436/117497 , Y10T436/143333 , Y10T436/25
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US20140202546A1
公开(公告)日：2014-07-24
申请号：US14184312
申请日：2014-02-19
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC: G05D7/06
CPC classification number: G05D7/0694 , B01F5/0471 , B01F13/0071 , B01J19/0046 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/0293 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N35/08 , G01N2035/1034 , Y10T137/0318
Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
Abstract translation: 本发明提供了微流体技术，其能够快速和经济地操作在瞳孔上的反应到微量级。
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公开(公告)号：US20240160231A1
公开(公告)日：2024-05-16
申请号：US18395300
申请日：2023-12-22
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC: G05D7/06 , B01F25/314 , B01F33/302 , B01J19/00 , B01L3/00 , B01L3/02 , G01N1/38 , G01N35/08
CPC classification number: G05D7/0694 , B01F25/314 , B01F33/3021 , B01J19/0046 , B01L3/0293 , B01L3/502784 , G01N1/38 , G01N35/08 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/502746 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N2035/1034 , Y10T137/0318
Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
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