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    Variable Valve Apparatus and Methods
    11.
    发明申请
    Variable Valve Apparatus and Methods 审中-公开
    可变阀装置及方法

    公开(公告)号：US20070148687A1

    公开(公告)日：2007-06-28

    申请号：US11684656

    申请日：2007-03-12

    Applicant: William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    Inventor： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

    Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

    Abstract translation: 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

    Heating element for a rotating multiplex fluorescence detection device
    12.
    发明申请
    Heating element for a rotating multiplex fluorescence detection device 审中-公开
    用于旋转多重荧光检测装置的加热元件

    公开(公告)号：US20070009382A1

    公开(公告)日：2007-01-11

    申请号：US11174691

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: G01N35/00

    CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

    Modular sample processing apparatus kits and modules
    13.
    发明申请
    Modular sample processing apparatus kits and modules 有权
    模块化样品处理设备套件和模块

    公开(公告)号：US20070007270A1

    公开(公告)日：2007-01-11

    申请号：US11174756

    申请日：2005-07-05

    Applicant: William Bedingham ,  Barry Robole

    Inventor： William Bedingham ,  Barry Robole

    IPC: F27B9/06 ,  F27D11/00

    CPC classification number: G01N35/025

    Abstract: Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.

    Abstract translation: 公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。 本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。 样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。 过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。 结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。 还公开了使用包括使处理模块和框架变形的样品处理装置的方法。

    Variable valve apparatus and methods
    15.
    发明申请
    Variable valve apparatus and methods 有权

    公开(公告)号：US20050126312A1

    公开(公告)日：2005-06-16

    申请号：US10734717

    申请日：2003-12-12

    Applicant: William Bedingham ,  Barry Robole

    Inventor： William Bedingham ,  Barry Robole

    IPC: B01L3/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/05 ,  G01N33/49

    CPC classification number: G01N21/05 ,  B01J2219/00891 ,  B01L3/502738 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677

    Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

    Biomedical sensor system
    19.
    发明授权
    Biomedical sensor system 有权
    生物医学传感器系统

    公开(公告)号：US08700118B2

    公开(公告)日：2014-04-15

    申请号：US12990064

    申请日：2009-04-29

    Applicant: Craig D. Oster ,  Hatim M. Carim ,  Casey L. Carlson ,  Vinod P. Menon ,  Jon A. Kirschhoffer ,  William Bedingham ,  Christopher R. Yungers

    Inventor： Craig D. Oster ,  Hatim M. Carim ,  Casey L. Carlson ,  Vinod P. Menon ,  Jon A. Kirschhoffer ,  William Bedingham ,  Christopher R. Yungers

    IPC: A61B5/0408 ,  A61B5/00

    CPC classification number: A61B5/0002 ,  A61B5/0006 ,  A61B5/04085 ,  A61B5/04087 ,  A61B5/0416 ,  A61B5/6831 ,  A61B2560/045 ,  A61B2562/17

    Abstract: A biomedical sensor system. The system can include a sensor adapted to create a signal based on a physiological characteristic from a subject, and a hub adapted to receive the signal from the sensor. The signal can include at least one of an electromagnetic signal, an electrical signal, an acoustic signal, a mechanical signal, a thermal signal, and a chemical signal. The system can further include a connector adapted to couple the sensor and the hub, the connector having a variable length, such that the sensor and the hub can be positioned a variable distance apart by changing the length of the connector. The connector can be adapted to provide a pathway between the sensor and the hub for the signal. A method of applying a biomedical sensor system to a subject can include changing the length of the variable-length connector to provide an appropriate distance between the sensor and the hub, and coupling the sensor to the subject.

    Abstract translation: 生物医学传感器系统。 系统可以包括适于基于来自对象的生理特征创建信号的传感器和适于从传感器接收信号的轮毂。 信号可以包括电磁信号，电信号，声信号，机械信号，热信号和化学信号中的至少一个。 该系统还可包括适于联接传感器和轮毂的连接器，连接器具有可变长度，使得传感器和轮毂可以通过改变连接器的长度而位于可变距离之间。 连接器可以适于在传感器和集线器之间提供用于信号的路径。 将生物医学传感器系统应用于对象的方法可以包括改变可变长度连接器的长度以在传感器和轮毂之间提供适当的距离，以及将传感器耦合到对象。

    ELECTRONIC STETHOSCOPE SYSTEM FOR TELEMEDICINE APPLICATIONS
    20.
    发明申请
    ELECTRONIC STETHOSCOPE SYSTEM FOR TELEMEDICINE APPLICATIONS 有权
    用于电视应用的电子硬脑膜系统

    公开(公告)号：US20110190665A1

    公开(公告)日：2011-08-04

    申请号：US12910086

    申请日：2010-10-22

    Applicant: William Bedingham ,  Craig D. Oster ,  Daniel J. Rogers

    Inventor： William Bedingham ,  Craig D. Oster ,  Daniel J. Rogers

    IPC: A61B7/04

    CPC classification number: A61B7/04

    Abstract: An electronic stethoscope includes a housing configured for hand-held manipulation, a transducer supported by the housing and configured to sense auscultation signals at a first location, and a headset coupled to the housing and configured to deliver audio corresponding to the auscultation signals through earpieces on the headset. The electronic stethoscope further includes a processor disposed in the housing and configured to convert the auscultation signals to first digital signals representative of the auscultation signals and to wirelessly transmit the first digital signals from the electronic stethoscope via a secure digital network to a second location such that the audio corresponding to the auscultation signals is provided to headsets of one or more additional electronic stethoscopes at the second location in substantial real time with the sensing of the auscultation sounds at the first location.

    Abstract translation: 电子听诊器包括被配置为用于手持操作的壳体，由壳体支撑并被配置为感测在第一位置处的听诊信号的传感器，以及耦合到壳体的头戴耳机，并且被配置为通过耳机将听诊信号传送到听筒 耳机。 电子听诊器还包括设置在外壳中并被配置为将听诊信号转换成表示听诊信号的第一数字信号的处理器，并且经由安全数字网络将第一数字信号从电子听诊器无线地传输到第二位置，使得 与第一位置处的听诊声音的感测相当，实质上实时地将与听诊信号对应的音频提供给位于第二位置的一个或多个附加电子听诊器的耳机。

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