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19 条记录 (耗时 0.035 秒)

    Method of preparing nucleic acids for detection
    11.
    发明申请
    Method of preparing nucleic acids for detection 有权
    制备核酸检测方法

    公开(公告)号：US20050112583A1

    公开(公告)日：2005-05-26

    申请号：US10703368

    申请日：2003-11-07

    申请人： Tim Patno ,  Jennifer Hollenstein ,  Christian Kronshage ,  Christopher Khoury ,  Mark Weber ,  Tom Westberg ,  William Cork

    发明人： Tim Patno ,  Jennifer Hollenstein ,  Christian Kronshage ,  Christopher Khoury ,  Mark Weber ,  Tom Westberg ,  William Cork

    IPC分类号： B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N20060101 ,  G01N35/10

    CPC分类号： C12Q1/6806 ,  B01L3/5025 ,  B01L3/5027 ,  B01L7/525 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0877 ,  B01L2400/0487 ,  G01N35/1097 ,  C12Q2563/155 ,  C12Q2565/519

    摘要： A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.

    摘要翻译： 提供了一种制备用于检测预定靶核酸的测试样品的方法和装置。 该方法包括以下步骤：提供包含与纳米颗粒连接的寡核苷酸并提供含有测试样品和测试探针的杂交单元的测试探针，其中所述杂交单元还包括目标样品基底和连接到第一侧的分布歧管 的基底。 该方法还包括以下步骤：将加工流体歧管夹紧到杂交单元的分配歧管上，使测试样品变性并制备用于通过在处理流体源歧管之间泵送多个处理流体来检测预定靶核酸的测试样品 以及分配多肽以将测试探针和预定靶核酸与目标样品底物杂交，以洗涤杂交样品并扩增杂交样品的可检测参数。

    Multi-chamber container with seal breach detection
    14.
    发明授权
    Multi-chamber container with seal breach detection 有权
    多室容器具有密封泄漏检测

    公开(公告)号：US08979817B2

    公开(公告)日：2015-03-17

    申请号：US13548349

    申请日：2012-07-13

    申请人： Terry Chung ,  William Cork ,  Kwang Suk Kim

    发明人： Terry Chung ,  William Cork ,  Kwang Suk Kim

    IPC分类号： A61M19/00 ,  A61J1/20 ,  A61J1/18 ,  A61J1/10

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/18 ,  A61J1/2024

    摘要： A container having multiple compartments formed by frangible seals in the interior chamber of the container is disclosed. The container comprises an indicator adapted to provide an indication that a seal breach between the chambers has occurred. Methods of forming a container having a seal breach detection indicator are also disclosed.

    摘要翻译： 公开了一种容器，其具有由容器的内部腔室中的易碎密封件形成的多个隔室。 容器包括适于提供发生在腔室之间的密封件破裂的指示的指示器。 还公开了形成具有密封突破检测指示器的容器的方法。

    Selective isolation and concentration of nucleic acids from complex samples
    17.
    发明申请
    Selective isolation and concentration of nucleic acids from complex samples 审中-公开
    来自复杂样品的核酸的选择性分离和浓缩

    公开(公告)号：US20070154903A1

    公开(公告)日：2007-07-05

    申请号：US11473996

    申请日：2006-06-23

    申请人： Sudhakar Marla ,  Anna Prokhorova ,  Susan Hetzel ,  William Cork

    发明人： Sudhakar Marla ,  Anna Prokhorova ,  Susan Hetzel ,  William Cork

    IPC分类号： C12Q1/68 ,  C12M3/00

    CPC分类号： B82Y10/00 ,  B82Y5/00 ,  C12N1/06 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q2537/125 ,  C12Q2527/125

    摘要： The present invention provides methods for detecting a target nucleic acid molecule in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules in a complex environment containing numerous non-nucleic acid components. In particular, the present invention provides methods and probes for isolating DNA with detergents and detecting a single nucleotide polymorphism (SNP) in a complex sample that comprises numerous non-nucleic acid components and nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules.

    摘要翻译： 本发明提供了检测样品中靶核酸分子的方法，该方法包含比包含许多非核酸组分的复杂环境中的扩增核酸分子具有更高生物学复杂性的核酸分子。 特别地，本发明提供了用洗涤剂分离DNA并检测复合物样品中的单核苷酸多态性（SNP）的方法和探针，该复合物样品包含比扩增的核酸更高的生物学复杂性的许多非核酸组分和核酸分子 分子。

    MULTI-CHAMBER CONTAINER WITH SEAL BREACH DETECTION
    18.
    发明申请
    MULTI-CHAMBER CONTAINER WITH SEAL BREACH DETECTION 有权
    具有密封性检测的多室容器

    公开(公告)号：US20130018353A1

    公开(公告)日：2013-01-17

    申请号：US13548349

    申请日：2012-07-13

    申请人： Terry Chung ,  William Cork ,  Kwang Suk Kim

    发明人： Terry Chung ,  William Cork ,  Kwang Suk Kim

    IPC分类号： A61J1/18

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/18 ,  A61J1/2024

    摘要： A container having multiple compartments formed by frangible seals in the interior chamber of the container is disclosed. The container comprises an indicator adapted to provide an indication that a seal breach between the chambers has occurred. Methods of forming a container having a seal breach detection indicator are also disclosed.

    摘要翻译： 公开了一种容器，其具有由容器的内部腔室中的易碎密封件形成的多个隔室。 容器包括适于提供发生在腔室之间的密封件破裂的指示的指示器。 还公开了形成具有密封突破检测指示器的容器的方法。

    AUTHORIZATION SCHEME TO MINIMIZE THE USE OF UNAUTHORIZED MEDICAL DEVICE DISPOSABLES ON A MEDICAL DEVICE INSTRUMENT
    19.
    发明申请
    AUTHORIZATION SCHEME TO MINIMIZE THE USE OF UNAUTHORIZED MEDICAL DEVICE DISPOSABLES ON A MEDICAL DEVICE INSTRUMENT 有权
    授权方案，以最小化在医疗器械仪器上使用未经授权的医疗器械处置

    公开(公告)号：US20110209212A1

    公开(公告)日：2011-08-25

    申请号：US12708964

    申请日：2010-02-19

    申请人： Douglas Newlin ,  Kevin Krause ,  Robert Crampton ,  John T. Foley ,  Brian Case ,  William Cork

    发明人： Douglas Newlin ,  Kevin Krause ,  Robert Crampton ,  John T. Foley ,  Brian Case ,  William Cork

    IPC分类号： G06F21/00 ,  H04L9/00 ,  A61M1/38

    CPC分类号： G05B1/00 ,  A61M1/3693 ,  A61M2205/12 ,  A61M2205/502 ,  A61M2205/60 ,  G06F19/3418 ,  G06F21/31 ,  G06F2221/2141 ,  G16H40/63 ,  H04L9/3226 ,  H04L63/08 ,  H04L63/083 ,  H04L2209/80 ,  H04L2209/88

    摘要： Systems, methods, apparatus, and computer readable media are provided for disposable component authentication with respect to a biological fluid processing device instrument. An example instrument authentication system includes a computer facilitating configuration and operation of the biological fluid processing instrument using a disposable component. A first interface is provided by the computer and is used by a service technician to configure the biological fluid processing instrument for a number of disposable components and to provide a service technician with a validation code. A key generator is to accept the validation code from the service technician and generate an authentication key in response to the entered validation code. A second interface is provided by the computer, the second interface prompting the service technician to enter an authentication key, wherein the authentication key authorizes use of a certain number of disposable components for the biological fluid processing instrument.

    摘要翻译： 提供了相对于生物流体处理装置仪器的一次性部件认证的系统，方法，装置和计算机可读介质。 示例性的仪器认证系统包括便于使用一次性部件的生物流体处理设备的配置和操作的计算机。 第一接口由计算机提供并由维修技术人员用于为多个一次性部件配置生物流体处理仪器，并向维修技术人员提供验证代码。 密钥生成器是接受来自维修技术人员的验证码，并响应输入的验证码生成认证密钥。 第二接口由计算机提供，第二接口提示服务技术人员输入认证密钥，其中认证密钥授权使用一定数量的一次性部件用于生物流体处理仪器。