公开(公告)号：US11846643B2

公开(公告)日：2023-12-19

申请号：US17211214

申请日：2021-03-24

Applicant: ALPHA TECHNOLOGIES SERVICES LLC

Inventor： Matthew Scot McMaster ,  Keith Wayne Buzek

IPC: G01N35/02 ,  G01N35/00

CPC classification number: G01N35/025 ,  G01N35/00029 ,  G01N2035/00049

Abstract: A test sample handling system for transporting test samples to a testing mechanism comprises a rotary sample holder including a carrier cylinder configured to rotate about a central rotational axis thereof and a carrier arm adjustable between a retracted position and an extended position. A carrier is configured to support one of the test samples and is removably coupled to the carrier cylinder. A lifter mechanism is adjustable between a lowered position and a raised position with the adjustment of the carrier arm from the retracted position to the extended position including a decoupling of the carrier from the carrier cylinder and a transporting of the carrier and the corresponding one of the samples to a position above the lifter mechanism. An adjustment of the lifter mechanism from the lowered position to the raised position includes a removal of the one of the samples from being supported by the carrier.

公开(公告)号：US11828766B2

公开(公告)日：2023-11-28

申请号：US16226164

申请日：2018-12-19

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Aleksandar Vacic ,  Nathan Purmort ,  Eric Stern ,  Anna Passernig ,  Paul Otten ,  Randy Tragni ,  Ronan Hayes ,  Andriy Tsupryk ,  Bruce Richardson

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/10 ,  B01J20/04 ,  C12Q1/18 ,  G01N21/01 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12M1/34 ,  G01N35/04 ,  G01N15/02

CPC classification number: G01N15/02 ,  B01J20/041 ,  C12Q1/18 ,  G01N21/01 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/028 ,  G01N35/1065 ,  C12M33/10 ,  C12M41/36 ,  C12M41/48 ,  C12M47/02 ,  G01N2021/0112 ,  G01N2035/00039 ,  G01N2035/00118 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00465 ,  G01N2035/00485 ,  G01N2035/00524 ,  G01N2035/00841 ,  G01N2035/0425

Abstract: In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.

公开(公告)号：US11826760B2

公开(公告)日：2023-11-28

申请号：US17865527

申请日：2022-07-15

Applicant: Leica Microsystems CMS GmbH

Inventor： Meret Vollenweider ,  Stephen Eric Zingelewicz ,  Alex David Corwin ,  Kashan Ali Shaikh ,  Jessica Godin Karp ,  Michael Steven Lazare ,  David Andrew Shoudy ,  Christine Lynne Surrette

IPC: B01L1/00 ,  B01L9/00 ,  B01L3/00 ,  F04B19/00 ,  G01N1/31 ,  G01N35/00

CPC classification number: B01L9/527 ,  B01L3/50273 ,  F04B19/006 ,  G01N1/312 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2400/0475 ,  B01L2400/0481 ,  F04B2203/0209 ,  G01N35/00029

Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.

公开(公告)号：US20230375583A1

公开(公告)日：2023-11-23

申请号：US18141374

申请日：2023-04-29

Applicant: Keith Louis De Santo

Inventor： Keith Louis De Santo

IPC: G01N35/02 ,  G01N35/00

CPC classification number: G01N35/025 ,  G01N35/00029 ,  G01N2035/00138

Abstract: A method and apparatus for detecting one or more of a matter and a plurality of microorganisms, comprising: collecting a sample comprising liquid, matter, and/or microorganisms using a plurality of remotely controlled unmanned land, air, and water self-propelled devices; introducing the sample into a sample reservoir connected to a liquid tube inlet; withdrawing the sample from the sample reservoir into the liquid tube having a plurality microscope slides embedded therein through a sample outlet; placing the sample on a sample surface of the plurality of microscope slides; illuminating the sample on the sample surface of the plurality of microscope slides with a light source; intermittently pumping the sample between the microscope slides from the sample reservoir; magnifying the sample on the sample surface of the microscope slides with an image enlargement device; detecting the amount of light transmitted through the sample using a photodetector and/or detecting fluorescence emitted from the sample on the sample surface of the microscope slides using a microscope; analyzing the light detected by the photodetector and/or generating a signal indicative of the fluorescence emitted from the sample on the sample surface of the microscope slides and transferring that signal to a computer software device to determine the presence of matter and microorganisms in the sample; transmitting or displaying the results of the matter and microorganisms detection; controlling the operation of pumps in the liquid tube using a control unit having a plurality of algorithms that manage the operation and identify and classify the sample; detecting a motility and mobility of microorganisms, color of matter, mass of matter, and type of contaminants or matter, wherein the matter and microorganisms is in a singular or combination form; and forecasting a plurality of events in outdoor and indoor environments from data obtained by step l.

公开(公告)号：US11815518B2

公开(公告)日：2023-11-14

申请号：US17368781

申请日：2021-07-06

Applicant: Ventana Medical Systems, Inc.

Inventor： Kurt Reinhardt ,  Charles D. Lemme ,  Glen Ward ,  William L. Richards ,  Wayne Showalter ,  Brandon Ambler ,  Austin Micheil Ashby ,  Chris Borchert ,  Devon C. Campbell ,  Kimberly Christensen ,  Matthew Freeman ,  Andrew Ghusson ,  Rick Griebel ,  Kendall B. Hendrick ,  Miroslav Holubec ,  Parula Mehta ,  Vince Rizzo

IPC: G01N35/00 ,  G01N1/31 ,  G01N1/36 ,  G01N1/30 ,  B01L9/00

CPC classification number: G01N35/00029 ,  B01L9/52 ,  G01N1/30 ,  G01N1/312 ,  G01N1/36 ,  G01N35/0099 ,  B01L2300/0822 ,  G01N35/00732 ,  G01N2035/00039 ,  G01N2035/00138 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.

公开(公告)号：US20230324421A1

公开(公告)日：2023-10-12

申请号：US18132115

申请日：2023-04-07

Applicant: 10x Genomics, Inc.

Inventor： Yiran ZHANG ,  Felice Alessio BAVA ,  Rhyan Blaine DOCKTER ,  Rajiv BHARADWAJ

IPC: G01N35/00 ,  B01L3/00

CPC classification number: G01N35/00029 ,  B01L3/502715 ,  G01N2035/00168 ,  B01L2200/0689 ,  B01L2200/025 ,  B01L2300/0627 ,  B01L2200/16

Abstract: Disclosed herein are systems for receiving a biological sample for analysis and methods for preparing and/or analyzing a biological sample. In various embodiments, a system includes a first layer comprising a first region configured to receive a sample, a gasket disposed on the first layer such that the gasket surrounds the first region, and a housing layer. The first layer is disposed between the gasket and the housing layer. The system further includes a clamp configured to apply a force on the gasket to form a liquid tight seal against the first layer.

公开(公告)号：US11782042B2

公开(公告)日：2023-10-10

申请号：US17643798

申请日：2021-12-10

Applicant: Becton, Dickinson and Company

Inventor： Weston F. Harding ,  Erik K. Witt ,  Austin Jason Mckinnon ,  Ray Isaacson ,  Bart Peterson ,  Marcel Arantes Souza ,  Matthew Oshinski

IPC: G01N21/94 ,  G01N33/15 ,  G01N1/10 ,  G01N35/00 ,  G01N1/02 ,  B01L3/00 ,  G01N21/84 ,  G01N1/00 ,  G01N1/38

CPC classification number: G01N33/15 ,  B01L3/5029 ,  G01N1/02 ,  G01N1/10 ,  G01N21/8483 ,  G01N21/94 ,  G01N35/00029 ,  B01L3/5082 ,  B01L3/50825 ,  B01L2200/082 ,  B01L2200/16 ,  B01L2200/185 ,  B01L2300/0825 ,  G01N1/38 ,  G01N35/00871 ,  G01N2001/002 ,  G01N2001/028 ,  G01N2001/1006 ,  G01N2035/00108 ,  G01N2035/00277 ,  G01N2035/00881

Abstract: Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection kit provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The kit also provides open and closed fluid transfer mechanism to transfer the collected fluid to a detection device while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.

公开(公告)号：US11779919B2

公开(公告)日：2023-10-10

申请号：US16351953

申请日：2019-03-13

Applicant: Zoetis Denmark ApS

Inventor： Niels Kristian Bau-Madsen ,  Lars Bue Nielsen ,  Martin Heller ,  Ole Kring ,  Olga Ordeig ,  Bent Overby

IPC: B01L3/00 ,  B01L9/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/64 ,  G01N35/00 ,  G01N21/25 ,  G01N27/403 ,  G01N21/03

CPC classification number: B01L3/502715 ,  B01L9/527 ,  G01N21/05 ,  G01N21/25 ,  G01N21/255 ,  G01N21/31 ,  G01N21/6428 ,  G01N27/403 ,  G01N35/00029 ,  G01N35/00732 ,  B01L2200/025 ,  B01L2300/02 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N2021/0346 ,  G01N2021/6439 ,  G01N2035/00237 ,  G01N2035/00752 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2201/062 ,  G01N2201/0627

Abstract: A microfluidic system includes a microfluidic cartridge and a detector assembly. The microfluidic cartridge includes a first and second side and at least one flow channel and an inlet to flow channel(s) for feeding a liquid sample, the flow channel(s) includes a plurality of first optical detection sites. The detector assembly includes a slot. The detector assembly and the microfluidic cartridge are constructed such that when the microfluidic cartridge is inserted to a first predetermined position into the slot, one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source, and when the cartridge is inserted to a second predetermined position into the slot, another one of the first optical detection sites of the microfluidic cartridge is positioned in the beam path of the first light source.

公开(公告)号：US11774463B2

公开(公告)日：2023-10-03

申请号：US16770198

申请日：2018-01-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Dennis R. Esterberg ,  Christie Dudenhoefer

IPC: G01N35/10 ,  G01N35/00 ,  B01L9/00

CPC classification number: G01N35/109 ,  B01L9/52 ,  G01N35/00029 ,  G01N35/1011 ,  B01L9/523 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0829 ,  G01N2035/00138 ,  G01N2035/1039

Abstract: In one example, dispenser stages described herein may include a dispenser platform comprising: a stage coupled to a rail system to move the stage in a first plane and a second plane, an alignment feature coupled to the stage to align a substrate nest coupled to the stage with a dispenser positioned above the stage, and a releasable fastener to couple the substrate nest to the stage.

公开(公告)号：US11713438B2

公开(公告)日：2023-08-01

申请号：US17120723

申请日：2020-12-14

Applicant: Perimeter Medical Imaging, Inc.

Inventor： Chao Fan ,  Elizabeth A. Munro ,  David Rempel ,  James Jackson

IPC: G01N1/28 ,  C12M1/00 ,  G01N35/00 ,  A61B10/00 ,  G02B21/34 ,  B01L3/00 ,  C12M1/26 ,  G01N33/483 ,  G06T7/00 ,  C12M3/00

CPC classification number: C12M1/007 ,  A61B10/0096 ,  B01L3/505 ,  C12M1/268 ,  C12M23/14 ,  C12M23/22 ,  G01N1/28 ,  G01N33/4833 ,  G01N35/00029 ,  G02B21/34 ,  G06T7/0012 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/123 ,  B01L2400/049 ,  C12M23/26 ,  C12M23/46 ,  G01N2035/00059

Abstract: Embodiments described herein relate to an apparatus for positioning and securing an excised biological tissue specimen for imaging and analysis. In some embodiments, an apparatus includes a sample bag defining an inner volume configured to receive a biological tissue sample, and a sealing member coupled to the sample bag. An imaging window is disposed and configured to be placed in contact with at least a portion of the biological tissue sample, and a positioning member is coupled to the imaging window and is configured to be disposed against the sealing member to substantially seal the inner volume. The positioning member includes a vacuum port disposed and configured to be aligned with a vacuum source to withdraw air from the inner volume of the sample bag.