公开(公告)号：US20240092819A1

公开(公告)日：2024-03-21

申请号：US18248988

申请日：2021-10-19

申请人： SANOFI

发明人： Bettina ELSHORST ,  Gerhard HESSLER ,  Armin HOFMEISTER ,  Ziyu LI ,  Christoph PÖVERLEIN ,  Herman SCHREUDER ,  Gernot ZECH

IPC分类号： C07H19/16 ,  C07D211/56 ,  C07H19/207 ,  C07H21/00 ,  C12N15/113

CPC分类号： C07H19/16 ,  C07D211/56 ,  C07H19/207 ,  C07H21/00 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/33 ,  C12N2310/351 ,  C12N2320/32

摘要： The present disclosure provides novel piperidine- and guanosine-derived ligands that bind specifically to asialoglycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs.

公开(公告)号：US20240076309A1

公开(公告)日：2024-03-07

申请号：US18225476

申请日：2023-07-24

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Michael Solomon Goldberg ,  Ellese Carmona

IPC分类号： C07H21/00 ,  A61K35/17 ,  C07K14/505 ,  C12P19/30

CPC分类号： C07H21/00 ,  A61K35/17 ,  C07K14/505 ,  C12P19/30 ,  A61K48/00

摘要： The present invention provides circularized RNA and methods of making, purifying, and using same.

公开(公告)号：US11896672B2

公开(公告)日：2024-02-13

申请号：US16092685

申请日：2017-04-11

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： James Heyes ,  Richard J. Holland ,  Alan D. Martin ,  Mark Wood

IPC分类号： A61K47/54 ,  A61K31/713 ,  C12N15/113 ,  A61K47/60 ,  C07C237/08 ,  C07H15/18 ,  C07C235/10 ,  C07H15/26 ,  C07J51/00 ,  C07H15/08 ,  A61K47/59 ,  C07J63/00 ,  C07H21/00 ,  C07D211/42 ,  C07D207/08 ,  C07D207/12 ,  C12N15/11 ,  C12N15/87

CPC分类号： A61K47/549 ,  A61K31/713 ,  A61K47/554 ,  A61K47/59 ,  A61K47/60 ,  C07C235/10 ,  C07C237/08 ,  C07H15/08 ,  C07H15/18 ,  C07H15/26 ,  C07H21/00 ,  C07J51/00 ,  C07J63/008 ,  C12N15/113 ,  C07D207/08 ,  C07D207/12 ,  C07D211/42 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2310/322 ,  C12N2310/3533

摘要： The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

公开(公告)号：US20230406874A1

公开(公告)日：2023-12-21

申请号：US18228969

申请日：2023-08-01

申请人： Illumina, Inc.

发明人： Frank J. Steemers ,  Kevin L. Gunderson ,  Kerri York ,  Ryan Christopher Smith

IPC分类号： C07H1/06 ,  C12Q1/6811 ,  C07H21/00 ,  C12N15/10 ,  C07D495/04

CPC分类号： C07H1/06 ,  C12Q1/6811 ,  C07H21/00 ,  C12N15/1003 ,  C07D495/04 ,  C07H1/00

摘要： Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.

公开(公告)号：US11793860B2

公开(公告)日：2023-10-24

申请号：US16991780

申请日：2020-08-12

申请人： The Regents of the University of California ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Leonard H. Rome ,  Valerie Ann Kickhoefer ,  Steven M. Dubinett ,  Sherven Sharma ,  Upendra K. Kar

IPC分类号： A61K38/19 ,  C07K14/52 ,  A61K47/69 ,  A61K38/00 ,  A61K38/45 ,  C12N9/10 ,  A61K35/12 ,  A61K48/00 ,  C07H21/00 ,  C07K7/06 ,  C07K14/47 ,  C12N5/0783 ,  C12N9/96 ,  C12N15/86 ,  G01N33/535

CPC分类号： A61K38/195 ,  A61K38/00 ,  A61K38/45 ,  A61K47/6921 ,  C07K14/521 ,  C12N9/1077 ,  C12Y204/0203 ,  A61K35/12 ,  A61K48/00 ,  C07H21/00 ,  C07K7/06 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/01 ,  C12N5/0636 ,  C12N9/96 ,  C12N15/86 ,  G01N33/535

摘要： The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.

公开(公告)号：US11753645B2

公开(公告)日：2023-09-12

申请号：US17685727

申请日：2022-03-03

申请人： AEROVIRUS TECHNOLOGIES INC.

发明人： Norman J Marchand ,  Thomas G Caltagirone ,  Albert Liao

IPC分类号： C12N15/115 ,  C07H21/00 ,  C12Q1/04 ,  A61P31/04 ,  A61K31/713 ,  C07K16/12 ,  C12N15/10 ,  C12Q1/689

CPC分类号： C12N15/115 ,  A61K31/713 ,  A61P31/04 ,  C07H21/00 ,  C07K16/1253 ,  C12N15/1048 ,  C12Q1/04 ,  C12Q1/689 ,  C12N2310/16 ,  G01N2333/30

摘要： The present disclosure relates to aptamers, polynucleotides, and nuclei acid molecules, which include a polynucleotide sequence capable of specifically binding polypeptides participating in M. hyopneumoniae infection. Also provided are methods of using nucleic acid molecules, polynucleotides and synthetic antibodies directed there against for detection, treating and neutralization of M. hyopneumoniae infection.

公开(公告)号：US20230227480A1

公开(公告)日：2023-07-20

申请号：US17960202

申请日：2022-10-05

申请人： Sanegene Bio USA Inc.

发明人： Weimin WANG ,  Xiaochuan CAI

IPC分类号： C07F9/22 ,  C07H21/00

CPC分类号： C07F9/222 ,  C07H21/00

摘要： The present disclosure provides linker compounds of Formula (I) or (II): pharmaceutically acceptable salts thereof, and related scaffolds and conjugates. The present disclosure also relates to uses of the linker compounds, scaffolds, and conjugates, e.g., in delivering nucleic acid and/or treating or preventing diseases.

公开(公告)号：US20230203474A1

公开(公告)日：2023-06-29

申请号：US18088628

申请日：2022-12-26

申请人： Industrial Technology Research Institute

发明人： Ming-Chun Lin ,  Hui-Ling Cheng ,  Chun-Ting Lai ,  Hua-Cheng Chou ,  Wei-Chin Huang ,  Chih-Hung Chen ,  Shu-Feng Chen

IPC分类号： C12N15/10 ,  C07H21/00 ,  C07D491/18 ,  C07H1/06

CPC分类号： C12N15/1006 ,  C07D491/18 ,  C07H1/06 ,  C07H21/00

摘要： A compound, a solid carrier including the same and a method for preparing a nucleic acid are provided. The compound has a structure represented by Formula (1) as follows.





In Formula (1), the definition of Y1, Y2, Z and * are the same as defined in the detailed description.

公开(公告)号：US20230167510A1

公开(公告)日：2023-06-01

申请号：US17920379

申请日：2021-04-22

申请人： The Regents of the University of California

发明人： Charles Chiu

IPC分类号： C12Q1/689 ,  C12Q1/6853 ,  C12Q1/6895 ,  C07H21/00

CPC分类号： C12Q1/689 ,  C12Q1/6853 ,  C12Q1/6895 ,  C07H21/00 ,  C12Q2600/16

摘要： Methods, compositions and kits for detection of a taxon of microorganisms in a sample are provided.

公开(公告)号：US11643660B2

公开(公告)日：2023-05-09

申请号：US16464057

申请日：2017-10-12

申请人： NEC Solution Innovators, Ltd. ,  National University Corporation Gunma University

发明人： Hirotaka Minagawa ,  Katsunori Horii ,  Jou Akitomi ,  Naoto Kaneko ,  Iwao Waga ,  Masayasu Kuwahara

IPC分类号： C07H19/10 ,  C07H19/20 ,  C12N15/115 ,  C12N15/10 ,  C07H1/00 ,  C07H21/00 ,  C07H21/04 ,  C07H21/02

CPC分类号： C12N15/115 ,  C07H1/00 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/1048

摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1).




In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.