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    A FRACTION COLLECTOR AND A METHOD FOR OPERATING THE SAME
    191.
    发明公开
    A FRACTION COLLECTOR AND A METHOD FOR OPERATING THE SAME 审中-公开

    公开(公告)号：US20230347262A1

    公开(公告)日：2023-11-02

    申请号：US17997874

    申请日：2021-06-21

    Applicant: CYTIVA SWEDEN AB

    Inventor： Mats Lundkvist ,  Tomas Yngve Agren ,  Erik Nilsson ,  Sebastian Skoglund

    IPC: B01D15/24

    CPC classification number: B01D15/247

    Abstract: The invention relates to a fraction collector apparatus (100) comprising: a support system (1, 2), a carrier (42) moveably supported by the support system (1, 2), an extension arm (3) connected to the carrier (42), at least one dispensing head (31) for dispensing droplets and moveably connected to the extension arm (3), wherein the dispensing head (31) and (carrier 42) are configured to move relative to the support system in a first plane, a tray area (11) designed to support at least one rack (6, 7), wherein the at least one rack (6, 7) is designed to hold at least one collection vessel (12, 14), wherein motion of said carrier (42) is achieved by a linear bearing Y-slide unit (41) wherein the linear bearing Y-slide unit (41) is arranged underneath a linear bearing Y-rail (40) and wherein the carrier (42) is attached to the linear bearing Y-slide unit (41).

    Method for determining analyte-ligand binding on a sensor surface
    192.
    发明授权
    Method for determining analyte-ligand binding on a sensor surface 有权

    公开(公告)号：US11796536B2

    公开(公告)日：2023-10-24

    申请号：US16932453

    申请日：2020-07-17

    Applicant: CYTIVA SWEDEN AB

    Inventor： Olof Karlsson

    IPC: G01N33/543

    CPC classification number: G01N33/54373 ,  G01N33/54393

    Abstract: The present invention provides a method of assaying a sample solution for the presence of a first analyte comprising: (a) providing a sensor surface having a ligand immobilized thereto; (b) flowing the sample solution over the sensor surface; and (c) detecting the presence or absence of binding of the analyte to the ligand on the sensor surface;
    wherein the contact time between the sample solution and the immobilized ligand is less than 15 seconds.

    Valve Unit for a Chromatography Apparatus
    195.
    发明公开
    Valve Unit for a Chromatography Apparatus 审中-公开

    公开(公告)号：US20230304974A1

    公开(公告)日：2023-09-28

    申请号：US18326838

    申请日：2023-05-31

    Applicant: Cytiva Sweden AB

    Inventor： Lars Olof Nils Rosengren ,  Kerstin Elisabet Erickson ,  Tim Francois

    IPC: G01N30/20 ,  G01N30/46

    CPC classification number: G01N30/20 ,  G01N30/468 ,  G01N2030/201 ,  G01N2030/205 ,  B01D15/1821

    Abstract: The present invention relates to a valve unit for a chromatography apparatus, the valve unit comprising a fluid inlet configured to receive an input fluid, a fluid outlet configured to provide an output fluid, a first pair of fluid ports configured to be coupled to a first column, a second pair of fluid ports configured to be coupled to a second column, a coupling valve assembly configured to direct fluid between a selection of the fluid inlet, the fluid outlet, the first pair of fluid ports and the second pair of fluid ports in response to one or more control signals, wherein the coupling valve assembly is configured to direct fluid using a selection of membrane valves coupled by fluid channels comprised in a body of the coupling valve assembly. The invention further relates to a chromatography apparatus comprising the valve unit and a membrane valve comprised in the valve unit.

    Method for optimization of a bioprocessing system
    197.
    发明授权
    Method for optimization of a bioprocessing system 有权

    公开(公告)号：US11714387B2

    公开(公告)日：2023-08-01

    申请号：US17268490

    申请日：2019-08-30

    Applicant: Cytiva Sweden AB

    Inventor： Mikael Johansson ,  Pasi Juntikka ,  Peter Toreheim ,  Shivakumar Selvaraj

    IPC: G05B13/02

    CPC classification number: G05B13/0205

    Abstract: The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data. The invention extends to a configuration system (500).

    METHOD AND APPARATUS FOR DETERMINING OPTICAL DENSITY OF A SOLUTION
    198.
    发明公开
    METHOD AND APPARATUS FOR DETERMINING OPTICAL DENSITY OF A SOLUTION 审中-公开

    公开(公告)号：US20230221250A1

    公开(公告)日：2023-07-13

    申请号：US17997641

    申请日：2021-05-17

    Applicant: CYTIVA SWEDEN AB

    Inventor： Hanno Ehring

    IPC: G01N21/59 ,  G01N21/31 ,  G01N21/45

    CPC classification number: G01N21/5907 ,  G01N21/314 ,  G01N21/45 ,  G01N2021/052

    Abstract: A method and instrument for determining optical density of a solution is disclosed. A flow cell 1 having at least three light paths (4a, 4b, 4c) is provided (100), wherein each light path has a respective predetermined path length, l. Absorbance readings are taken (400), A, of the solution at the at least three light paths (4a, 4b, 4c). For each pair of light paths, a slope, αc, is calculated (500) by dividing a difference in absorbance reading, ΔA, with a difference in path length, Δl. The calculated slopes, αc, are compared (600), and a) if the calculated slopes, αc, are the same, the slope is used for determining (700) optical density of the solution, or b) if he calculated slopes, αc, are not the same, the steepest slope of the calculated slopes is used for determining (701a) optical density of the solution, or the slope of the calculated slopes being in the range of an absorbance reading of 0.01 to 2 is used for determining (701b) optical density of the solution

    OPTICAL FLOW CELL FOR BIOPROCESSING
    199.
    发明公开
    OPTICAL FLOW CELL FOR BIOPROCESSING 审中-公开

    公开(公告)号：US20230221241A1

    公开(公告)日：2023-07-13

    申请号：US17997644

    申请日：2021-06-10

    Applicant: CYTIVA SWEDEN AB

    Inventor： Hanno Ehring ,  Klaus Gebauer

    IPC: G01N21/05 ,  G01N21/15

    CPC classification number: G01N21/05 ,  G01N21/15 ,  G01N2021/052 ,  G01N2201/0245

    Abstract: Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

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