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    METHOD AND SYSTEM FOR MICROFLUIDIC DEVICE AND IMAGING THEREOF
    194.
    发明申请
    METHOD AND SYSTEM FOR MICROFLUIDIC DEVICE AND IMAGING THEREOF 有权
    微流体装置及其成像方法与系统

    公开(公告)号：US20120242825A1

    公开(公告)日：2012-09-27

    申请号：US13360591

    申请日：2012-01-27

    Applicant: Emerson Chueng Quan ,  Colin Jon Taylor ,  Michael Lee ,  Christopher G. Cesar ,  Greg Harris ,  Gang Sun

    Inventor： Emerson Chueng Quan ,  Colin Jon Taylor ,  Michael Lee ,  Christopher G. Cesar ,  Greg Harris ,  Gang Sun

    IPC: H04N7/18

    CPC classification number: G01N33/00 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  Y10T436/11

    Abstract: A method for producing an image of an object within a chamber of a microfluidic device includes providing the microfluidic device having x, y, and z dimensions and a chamber depth center point located along the z dimension. The chamber depth center point is located a known z dimension distance from a fiducial marking embedded within the microfluidic device. The method also includes placing the microfluidic device within an imaging system that includes an optical device capable of detecting the fiducial marking. The optical device defines an optical path axially aligned with the z dimension and has a focal plane perpendicular to the optical path. When the focal plane is moved along the optical path, the fiducial marking is maximally detected when the focal plane is at the z depth in comparison to when the focal plane is not substantially in-plane with the z depth.

    Abstract translation: 用于在微流体装置的腔室内产生物体的图像的方法包括提供具有x，y和z尺寸的微流体装置以及沿着z维度定位的腔室中心点。 腔室深度中心点位于与嵌入在微流体装置内的基准标记的已知z维距离。 该方法还包括将微流体装置放置在包括能够检测基准标记的光学装置的成像系统内。 光学装置限定与z尺寸轴向对准的光路，并且具有垂直于光路的焦平面。 当焦平面沿着光路移动时，当焦平面与z深度基本上不在平面内时，当焦平面处于z深度时，基准标记被最大程度地检测。

    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    196.
    发明申请
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 失效
    具有可拆卸盖的微流体装置以及制造和应用方法

    公开(公告)号：US20120195810A1

    公开(公告)日：2012-08-02

    申请号：US13499879

    申请日：2010-09-09

    Applicant: David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    Inventor： David Cohen ,  Andrew May ,  Martin Pieprzyk ,  Brian Fowler ,  Kim Huat Lee ,  Jun Yan ,  Ming Fang Zhou ,  Seng Beng Ng

    IPC: B01L3/00 ,  B32B38/00

    CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/12 ,  B01L2300/045 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  G01N1/405

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

    Abstract translation: 本发明包括具有微型空腔的​​微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。 微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。 可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。 当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。 该室可能在PCR反应内部形成大分子晶体或产生内含物。 本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。 本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

    Method and system for crystallization and X-ray diffraction screening
    198.
    发明授权
    Method and system for crystallization and X-ray diffraction screening 有权
    用于结晶和X射线衍射筛选的方法和系统

    公开(公告)号：US07974380B2

    公开(公告)日：2011-07-05

    申请号：US12118185

    申请日：2008-05-09

    Applicant: Brian Fowler ,  Andrew May

    Inventor： Brian Fowler ,  Andrew May

    IPC: G01N23/20

    CPC classification number: G01N23/20025

    Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.

    Abstract translation: 集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。 第一结构被配置为提供通过多个通道的一种或多种材料的流动。 集成流体回路还包括耦合到衬底层的第二结构。 第二结构包括被配置为接收致动压力的多个控制通道。 集成流体回路的特征在于厚度小于1.5mm。

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