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    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
    3.
    发明授权
    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效
    用于电泳和电渗设备的无气泡和压力产生电极

    公开(公告)号：US07357852B2

    公开(公告)日：2008-04-15

    申请号：US10984239

    申请日：2004-11-09

    申请人： Timothy M. Woudenberg ,  Zbigniew T. Bryning ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Zbigniew T. Bryning ,  Reid B. Kowallis

    IPC分类号： G01N27/453 ,  C12Q1/68 ,  B01L3/00

    CPC分类号： G01N27/44704 ,  C02F1/46109 ,  C02F1/469

    摘要： Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.

    摘要翻译： 提供无气泡电极，包括无气泡电极的电化学电池，分析装置及其制备和使用方法。 分析装置各自包括至少一个无气泡电极。 还提供了包括电化学电池和样品容纳装置的分析装置，其中电化学电池包括阳极储存器，阴极储存器，阳极储存器和阴极储存器之间的电连接以及设置在阴极储存器内的第一无气泡电极 一个阳极储层和阴极储层。 第二电极设置在另一储存器内，并且提供具有通常与第一电极电接触的正端子的电源，以及通常与第二电极电接触的负极端子。 分析装置还包括用于切换电源的端子与第一和第二电极之间的触点的电源极性反转装置。 样品容纳装置包括样品容纳室，其具有用于将样品引入室中并且相对于电化学电池定位的开口，使得由电化学电池产生的电场可以影响设置在电化学电池中的样品的组分的性质 样品容纳室。 还提供了压力发生电池。

    Fluid Processing Device Comprising Radial Channels
    6.
    发明申请
    Fluid Processing Device Comprising Radial Channels 审中-公开
    包括径向通道的流体处理装置

    公开(公告)号：US20090317824A1

    公开(公告)日：2009-12-24

    申请号：US12548409

    申请日：2009-08-26

    申请人： Timothy M. Woudenberg ,  Reid B. Kowallis

    发明人： Timothy M. Woudenberg ,  Reid B. Kowallis

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    METHODS, SYSTEMS AND APPARATUS FOR LIGHT CONCENTRATING MECHANISMS
    9.
    发明申请
    METHODS, SYSTEMS AND APPARATUS FOR LIGHT CONCENTRATING MECHANISMS 审中-公开
    用于光浓缩机制的方法，系统和装置

    公开(公告)号：US20080066549A1

    公开(公告)日：2008-03-20

    申请号：US11857419

    申请日：2007-09-18

    申请人： Mark F. OLDHAM ,  Eric S. Nordman ,  Charles R. Connell ,  Timothy M. Woudenberg

    发明人： Mark F. OLDHAM ,  Eric S. Nordman ,  Charles R. Connell ,  Timothy M. Woudenberg

    IPC分类号： G01N33/00

    CPC分类号： G01N21/648 ,  G01N2021/6432

    摘要： An embodiment relates generally to a method for analysis of a nucleic acid. The method includes providing for a resonant structure configured to couple with one or more fluorescently labeled nucleic acids and directing an excitation light from a source on the resonant structure. The method also includes generating plasmons on the surface of the resonant structure where the analyte is fixed at a point of energy concentration of the resonant structure.

    摘要翻译： 实施方案一般涉及核酸分析方法。 该方法包括提供构造成与一个或多个荧光标记的核酸耦合并将来自源的激发光引导到谐振结构上的谐振结构。 该方法还包括在谐振结构的表面上产生等离子体激元，其中分析物固定在谐振结构的能量集中点处。