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公开(公告)号：US20190389901A1
公开(公告)日：2019-12-26
申请号：US16561453
申请日：2019-09-05
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , John P. Amara
Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
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公开(公告)号：US20190210017A1
公开(公告)日：2019-07-11
申请号：US16351828
申请日：2019-03-13
Applicant: EMD Millipore Corporation
Inventor： Terry Gaige , Andrew Zayac , Paul Sydlowski , Philip Lee
Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.
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公开(公告)号：US20190153027A1
公开(公告)日：2019-05-23
申请号：US16259489
申请日：2019-01-28
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/18 , C07K16/00 , B01D15/08 , C07K1/22 , C07K1/36 , B01D61/14 , C07K16/06 , C07K1/34 , B01D15/12
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US10272639B2
公开(公告)日：2019-04-30
申请号：US15544644
申请日：2016-03-22
Applicant: EMD Millipore Corporation
Inventor： David DeCoste , Joseph Cianciolo , Michael Furbush , John Saragosa
IPC: B32B5/02 , B32B27/08 , B32B27/12 , B32B27/32 , B32B27/34 , B32B27/40 , B01L3/00 , B65D65/40 , B65D75/58 , G01M3/32
Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.
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公开(公告)号：US10252199B2
公开(公告)日：2019-04-09
申请号：US15448248
申请日：2017-03-02
Applicant: EMD Millipore Corporation
Inventor： Onur Y. Kas , Mikhail Kozlov , Wilson Moya , Sherry A. Leon , Philip Goddard , Jibin Hao , Gabriel Tkacik
IPC: B01D39/16 , B01D39/18 , B01D39/14 , A61L2/02 , C12N7/00 , D01D1/02 , D01D5/00 , D01F6/96 , B01D69/02 , B01D69/10 , B01D39/04 , B01D39/00 , B01D67/00 , B01D61/14
Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
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Patent Agency Ranking
226.发明授权公开(公告)号：US10195550B2
公开(公告)日：2019-02-05
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US10190085B2
公开(公告)日：2019-01-29
申请号：US15163818
申请日：2016-05-25
Applicant: EMD Millipore Corporation
Inventor： Philip J. Lee , Terry Gaige , Wei Hsuan (Jessie) Ho
IPC: C12M3/06 , C12M1/00 , C12Q1/02 , C12M1/34 , B01L3/00 , B01L7/00 , C12M1/107 , C12M1/02 , C12M1/36 , G01N33/50 , G01N33/574
Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems are disclosed. Various embodiments relate to assays, systems, and/or devices for culturing cells or other biologic material in controlled environments and are applicable to related fields generally using microfluidic systems. Particular embodiments involve configurations that can be used with various standard automated handling systems, with active or passive loading and perfusion of medium and to provide high-throughput multi-assay automated systems for culturing, viewing, and analyzing cell growth, invasion, movement, chemotaxis or other properties. More specifically, specific embodiments relate to heat control systems for microfluidic culture plates and other automated systems for culture plates.
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公开(公告)号：US10174278B2
公开(公告)日：2019-01-08
申请号：US15175449
申请日：2016-06-07
Applicant: EMD Millipore Corporation
Inventor： Paul Ju-Sung Hung , Philip Janmin Lee
IPC: C12M1/32 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/34 , C12M1/36 , F16K99/00 , B29C65/00 , G01N33/543 , F16K27/02 , C12Q1/02 , G01N33/50 , G01N35/00
Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.
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229.发明授权公开(公告)号：US10138453B2
公开(公告)日：2018-11-27
申请号：US15163368
申请日：2016-05-24
Applicant: EMD Millipore Corporation
Inventor： Paul J. Hung , Philip J. Lee
Abstract: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture.
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公开(公告)号：US10054536B2
公开(公告)日：2018-08-21
申请号：US15163398
申请日：2016-05-24
Applicant: EMD Millipore Corporation
Inventor： Philip Janmin Lee , Paul Ju-Sung Hung , Narendra Maheshri
IPC: G01N15/14 , B01L3/00 , G01N33/487 , G01N33/543 , G01N15/00
CPC classification number: G01N15/1484 , B01L3/502707 , B01L3/502761 , B01L2200/0668 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N33/487 , G01N33/54366 , G01N2015/0065 , G01N2015/1493
Abstract: The device and method relate to microfluidic particle analysis. The device is designed for trapping particles for solution analysis. Exemplary particles include beads and cells. The device has a microfluidics body, and a microfluidics channel formed in the body for receiving particles at an upstream region thereof. The channel has a deformable wall portion that defines a particle-capture region, and is responsive to a change in fluid pressure applied thereto, to selectively vary the particle-flow dimensions of the capture region. In this way, particles having a given size may be selectively retained in the capture region. In one embodiment, the deformable wall portion is expandable in response to a positive fluid pressure applied within the channel. In another embodiment, the deformable wall portion is expandable in response to a negative pressure applied to a cavity communicating with the wall portion, external to the channel.
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