公开(公告)号：US20130196350A1

公开(公告)日：2013-08-01

申请号：US13755234

申请日：2013-01-31

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steven R. Binder ,  Michelle Delanoy ,  Audrey Arjomandi ,  John Flanagan

IPC: G01N33/68 ,  G01N33/74

CPC classification number: G01N33/6893 ,  G01N33/57449 ,  G01N33/6854 ,  G01N33/74

Abstract: Improved ovarian cancer assays are provided.

Abstract translation: 提供改进的卵巢癌检测。

公开(公告)号：US20130109807A1

公开(公告)日：2013-05-02

申请号：US13654802

申请日：2012-10-18

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Peter S. GAGNON

IPC: C07K1/20 ,  C08F26/10

CPC classification number: C07K16/065

Abstract: The present invention provides chromatography methods for removing a virucidal agent from a target protein such as an antibody. The method uses a hydrophobic, negatively charged mixed mode support that has high affinity for both the target protein and the virucidal agent. The method provides conditions that favor dissociation of the virucidal agent from the protein, allowing the virucidal agent to bind strongly to the support. The target protein is then eluted from the support under conditions such that the virucidal agent remains bound to the support.

Abstract translation: 本发明提供了从靶蛋白如抗体中除去杀病毒剂的层析方法。 该方法使用对靶蛋白和杀病毒剂具有高亲和力的疏水性带负电荷的混合模式载体。 该方法提供有利于从杀虫剂与蛋白质解离的条件，使得杀病毒剂与载体强烈结合。 然后在使得杀病毒剂保持与载体结合的条件下从载体上洗脱靶蛋白质。

公开(公告)号：US20040258575A1

公开(公告)日：2004-12-23

申请号：US10885938

申请日：2004-07-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Brian A. Perry

IPC: B01L011/00

CPC classification number: B01L3/5025 ,  G01N30/466 ,  G01N30/6043 ,  G01N30/6047 ,  G01N30/6091

Abstract: An adapter plate transforms a vacuum manifold designed for standard multi-well plates that are commonly used in biochemical laboratories into one that can be used for columns such as chromatographic columns, filtration columns, and the like. The plate contains an array of male-female-type complementary connectors, each connector fitted with a removable plug that seals the connector off when not in use. The plate thus allows the manifold to be used for as few as one column or any number up to the total number of connectors in the plate.

Abstract translation: 适配器板将设计用于生物化学实验室通常使用的标准多孔板的真空歧管转换成可用于色谱柱，过滤柱等柱。 该板包含一个阳 - 阴型互补连接器阵列，每个连接器都配有可拆卸的插头，用于在不使用时将连接器密封。 因此，该板允许歧管用于少至一列或任何数量，直到板中的连接器总数。

公开(公告)号：US20040195193A1

公开(公告)日：2004-10-07

申请号：US10408758

申请日：2003-04-03

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Nasser Jafari ,  Lawrence J. Blecka

IPC: A47B073/00

CPC classification number: B01L9/06 ,  B01L2200/025

Abstract: A tube rack for holding and transporting sample tubes or other liquids in an automated analyzer is built to accommodate tubes of different sizes in a stable aligned configuration, the rack containing a row of parallel open-top tube chambers, each chamber containing two sets of resilient tabs integrally molded with the chamber walls and at different heights in the chamber.

Abstract translation: 用于在自动分析器中保持和运送样品管或其他液体的管架被构建成容纳具有稳定对准构型的不同尺寸的管，该架包含一排平行的开放式顶管管腔，每个室包含两组弹性 与室壁整体成型并且在室中的不同高度处的突片。

公开(公告)号：US20040126904A1

公开(公告)日：2004-07-01

申请号：US10734957

申请日：2003-12-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Michael I. Watkins ,  Richard B. Edwards

IPC: G01N033/553

CPC classification number: G01N33/54326 ,  G01N33/537 ,  G01N33/54333 ,  G01N33/545 ,  G01N33/56994 ,  G01N33/582 ,  G01N33/6854 ,  Y10S435/973 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989 ,  Y10T428/2991

Abstract: Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the solid phase and yields an individual result for each analyte. The particles are distinguishable from each other by characteristics that permit them to be differentiated into groups, each group carrying an assay reagent bonded to the particle surface that is distinct from the assay reagents of particles in other groups. The magnetic particles facilitate separation of the solid and liquid phases, permitting the assays to be performed by automated equipment. Assays are also disclosed for the simultaneous detection of antibodies of different classes and a common antigen specificity or of a common class and different antigen specificities. Each type is accomplished by immunological binding at the surfaces of two distinct solid phases in a sequential manner with dissociation of the binding and washing of the solid phase in between the binding steps.

Abstract translation: 在单一生物样品中的不同分析物的非均相测定在多重测定中同时进行，其结合流式细胞术和使用磁性颗粒作为固相，并为每种分析物产生单独的结果。 颗粒可通过允许将其分成组的特征彼此区分，每个组携带与颗粒表面结合的测定试剂，其不同于其它组中的颗粒的测定试剂。 磁性颗粒促进固相和液相的分离，允许通过自动化设备进行测定。 还公开了用于同时检测不同类型的抗体和共同抗原特异性或共同类别和不同抗原特异性的测定。 每种类型通过在两个不同的固相的表面之间的顺序方式通过在结合步骤之间的结合和洗涤固相的解离来实现。

公开(公告)号：US20040002095A1

公开(公告)日：2004-01-01

申请号：US10394492

申请日：2003-03-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jason Liu ,  John Wesley Breneman III ,  Arlene Carillo ,  Craig Hixson

IPC: C12Q001/68 ,  C07H021/04 ,  C12P019/34 ,  C07K016/46

CPC classification number: C12Q1/682 ,  C12Q2525/161 ,  C12Q2525/151 ,  C12Q2563/179

Abstract: The present invention resides in a detection agent that can be used to amplify a detection signal for a target molecule. The detection agent contains a linear first single-stranded nucleic acid attached to a capture moiety that specific binds the target molecule of interest. The first single-stranded nucleic acid includes a plurality of repeat sequences, each of which is non-homopolymeric and can specifically bind to a second single-stranded nucleic acid that has at least one detectable label. Related method for using the claimed detection agent to amplify a detection signal and a kit for this purpose are also disclosed.

Abstract translation: 本发明涉及可用于放大靶分子检测信号的检测剂。 检测剂含有连接到特异性结合感兴趣的靶分子的捕获部分的线性第一单链核酸。 第一单链核酸包括多个重复序列，每个重复序列均为非均聚物并且可以特异性结合至少具有至少一个可检测标记的第二单链核酸。 还公开了使用所要求保护的检测剂放大检测信号的相关方法和用于此目的的试剂盒。

公开(公告)号：US20030191074A1

公开(公告)日：2003-10-09

申请号：US10057928

申请日：2002-01-29

Applicant: Bio-Rad Laboratories Inc.

Inventor： David Segev

IPC: A61K048/00 ,  C07H021/04 ,  A61K031/675 ,  A61K031/52 ,  A61K031/506

CPC classification number: C12Q1/6839 ,  C07B2200/11 ,  C12Q1/6832 ,  C12Q2525/117 ,  C12Q2525/113

Abstract: A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and rises of the compound, particularly in antisense therapy.

Abstract translation: 包含具有多个手性碳原子的骨架的化合物，所述骨架具有多个配体，每个配体各自与多个手性碳原子的手性碳原子结合，所述配体包括一个或多个相邻的一对 各自含有选自天然存在的核碱基和核碱基结合基团的部分的配体，其中所述一个或多个对的部分通过连接体链彼此直接连接; 用于合成化合物的结构单元; 化合物的升高，特别是在反义治疗中。

公开(公告)号：US20030162891A1

公开(公告)日：2003-08-28

申请号：US10087140

申请日：2002-02-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Cory M. Panattoni

IPC: C08K003/00 ,  C08L001/00

CPC classification number: G01N27/44747 ,  C08F220/56 ,  C08K5/17 ,  G01N27/44704 ,  Y10S524/916 ,  Y10S526/934 ,  C08L33/26

Abstract: Irregularities in the pore structures of polyacrylamide gels that are formed in cassettes against plastic walls are reduced or eliminated by the inclusion of an oxygen scavenger in the gel-forming solution. Avoidance of the irregularities results in electropherograms with fewer distortions in the solute bands.

Abstract translation: 通过在凝胶形成溶液中包含氧清除剂，减少或消除了在塑料壁上形成的聚丙烯酰胺凝胶的孔结构中的不规则性。 避免不规则性导致电泳图在溶质带中具有较少的失真。

公开(公告)号：US20030148972A1

公开(公告)日：2003-08-07

申请号：US10138888

申请日：2002-05-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

IPC: A61K048/00 ,  C12Q001/68 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/805

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/70539 ,  C12Q1/6883

Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

公开(公告)号：US20030113801A1

公开(公告)日：2003-06-19

申请号：US10263436

申请日：2002-10-01

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steven R. Binder ,  Jodi L. Goodrich ,  Zara Safarian

IPC: G01N033/53

CPC classification number: G01N33/96 ,  G01N2333/9108 ,  Y10S435/973

Abstract: Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.