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61 条记录 (耗时 0.015 秒)

    SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME
    23.
    发明申请
    SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME 审中-公开
    用于分析自组装分子的覆盖的基板和使用其的分析方法

    公开(公告)号：US20100015718A1

    公开(公告)日：2010-01-21

    申请号：US12517769

    申请日：2007-11-26

    申请人： Chil-Seong Ah ,  Ansoon Kim ,  Han-Young Yu ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In-Bok Baek ,  Chan-Woo Park ,  Seongjae Lee

    发明人： Chil-Seong Ah ,  Ansoon Kim ,  Han-Young Yu ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In-Bok Baek ,  Chan-Woo Park ,  Seongjae Lee

    IPC分类号： G01N33/00

    CPC分类号： G01N33/5308 ,  C12Q1/6825 ,  G01N33/54313 ,  G01N33/54393 ,  Y10T436/143333

    摘要： Provided are a substrate for analyzing the coverage of self-assembled molecules and a method for analyzing the coverage of the self-assembled molecules in nanowire and nanochannel patterned on solid surface, solid surface, or bulk solid surface by using the nanoparticles. According to the method, the presence of specific functional groups of self-assembled molecules and the degree of reaction can be analyzed by introducing nanoparticles to a biomaterial immobilization substrate including self-assembled molecules and measuring the number of gold nanoparticles existing on the surface. The substrate for analyzing the coverage of self-assembled molecules includes: a biomaterial immobilization substrate; a self-assembled molecular layer formed on the substrate and having a functional group capable of reacting with an amine group; a capture DNA molecule having an amine group bounded to the self-assembled molecular layer; and a probe DNA molecule bound to the capture DNA molecule and having nanoparticles attached to on the surface.

    摘要翻译： 本发明提供了一种用于分析自组装分子的覆盖物的底物以及通过使用纳米颗粒分析在固体表面，固体表面或体固体表面上图案化的纳米线和纳米通道中的自组装分子的覆盖率的方法。 根据该方法，可以通过将纳米颗粒引入包括自组装分子的生物材料固定化基质并测量表面上存在的金纳米颗粒的数量来分析自组装分子的特定官能团的存在和反应程度。 用于分析自组装分子的覆盖的底物包括：生物材料固定基质; 形成在基板上并具有能够与胺基反应的官能团的自组装分子层; 具有与自组装分子层结合的胺基的捕获DNA分子; 和与捕获DNA分子结合并且具有附着在表面上的纳米颗粒的探针DNA分子。

    METHOD AND APPARATUS FOR MEASURING ISOELECTRIC POINT USING FIELD EFFECT TRANSISTOR
    26.
    发明申请
    METHOD AND APPARATUS FOR MEASURING ISOELECTRIC POINT USING FIELD EFFECT TRANSISTOR 失效
    使用场效应晶体管测量电压点的方法和装置

    公开(公告)号：US20110139637A1

    公开(公告)日：2011-06-16

    申请号：US13058120

    申请日：2008-12-16

    申请人： Chil Seong Ah ,  Ansoon Kim ,  Chan Woo Park ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In Bok Baek ,  Taeyoub Kim ,  Gun Yong Sung ,  Seon-Hee Park ,  Han Young Yu

    发明人： Chil Seong Ah ,  Ansoon Kim ,  Chan Woo Park ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In Bok Baek ,  Taeyoub Kim ,  Gun Yong Sung ,  Seon-Hee Park ,  Han Young Yu

    IPC分类号： G01N27/403 ,  G01N27/414

    CPC分类号： G01N27/4145

    摘要： Provided are a method and apparatus for measuring an isoelectric point using a field effect transistor. The method includes providing a field effect transistor including a substrate, source and drain electrodes disposed on the substrate and spaced apart from each other, and a channel region between the source and drain electrodes, providing a first electrolyte solution having a first concentration to the channel region of the field effect transistor and measuring a first current value of the channel region between the source and drain electrodes, providing a second electrolyte solution having a second concentration greater than the first concentration and measuring a second current value of the channel region between the source and drain electrodes, and determining as the isoelectric point of the field effect transistor or a material disposed on the field effect transistor using a difference between the first and second current values.

    摘要翻译： 提供了使用场效应晶体管测量等电点的方法和装置。 该方法包括提供场效应晶体管，该场效应晶体管包括衬底，设置在衬底上的源电极和漏极彼此间隔开的沟道区，以及在源电极和漏电极之间的沟道区域，提供具有第一浓度到沟道的第一电解质溶液 区域，并且测量源极和漏极之间的沟道区的第一电流值，提供具有大于第一浓度的第二浓度的第二电解质溶液，并测量源极之间的沟道区的第二电流值 和漏电极，并且使用第一和第二电流值之间的差来确定场效应晶体管的等电点或设置在场效应晶体管上的材料。

    BIOCHIP AND METHOD OF DETECTING REACTION FROM THE SAME
    27.
    发明申请
    BIOCHIP AND METHOD OF DETECTING REACTION FROM THE SAME 审中-公开
    检测反应物的生物学和方法

    公开(公告)号：US20110091905A1

    公开(公告)日：2011-04-21

    申请号：US12893166

    申请日：2010-09-29

    申请人： Chil Seong AH ,  Gun Yong Sung ,  Wan Joong Kim ,  Bong Kyu Kim ,  Jong Cheol Hong ,  Chul Huh ,  Seon Hee Park

    发明人： Chil Seong AH ,  Gun Yong Sung ,  Wan Joong Kim ,  Bong Kyu Kim ,  Jong Cheol Hong ,  Chul Huh ,  Seon Hee Park

    IPC分类号： G01N33/53 ,  G01N21/17 ,  C12M1/34 ,  G01N30/00

    CPC分类号： G01N33/5302 ,  G01N21/31

    摘要： Provided are a biochip and a method of detecting a reaction from the biochip. This method includes preparing a first mixture solution of polyvinylpyrrolidone (PVP) and a sample including target molecules, measuring absorbance or transmittance of the first mixture solution, preparing a second mixture solution including the PVP, the sample, and a receptor of the target molecules, measuring absorbance or transmittance of the second mixture solution, and calculating an absorbance or transmittance difference between the first mixture solution and the second mixture solution. Thus, it is possible to reduce the production cost of the biochip by inducing a reaction of an antigen and an antibody using PVP. Further, it is possible to detect an accurate quantity of the antigen by analyzing a quantity of antigen on the basis of the absorbance or transmittance difference.

    摘要翻译： 提供了一种生物芯片和从生物芯片检测反应的方法。 该方法包括制备聚乙烯吡咯烷酮（PVP）的第一混合溶液和包含靶分子的样品，测量第一混合溶液的吸光度或透射率，制备包含PVP，样品和靶分子的受体的第二混合溶液， 测量第二混合溶液的吸光度或透射率，并计算第一混合溶液和第二混合溶液之间的吸光度或透射率差异。 因此，通过使用PVP诱导抗原和抗体的反应，可以降低生物芯片的生产成本。 此外，可以通过基于吸光度或透射率差异分析抗原量来检测精确量的抗原。

    BIOSENSOR AND METHOD OF DRIVING THE SAME
    28.
    发明申请
    BIOSENSOR AND METHOD OF DRIVING THE SAME 失效
    生物传感器及其驱动方法

    公开(公告)号：US20110068015A1

    公开(公告)日：2011-03-24

    申请号：US12703939

    申请日：2010-02-11

    申请人： Chan Woo Park ,  Chang Geun Ahn ,  Chil Seong Ah ,  Tae Youb Kim ,  An Soon Kim ,  Jong Heon Yang ,  Gun Yong Sung

    发明人： Chan Woo Park ,  Chang Geun Ahn ,  Chil Seong Ah ,  Tae Youb Kim ,  An Soon Kim ,  Jong Heon Yang ,  Gun Yong Sung

    IPC分类号： G01N27/26 ,  G01F1/64

    CPC分类号： G01N27/4145

    摘要： Provided are a biosensor and a method of driving the same. The biosensor includes a transistor including a substrate including a source, a drain, and a channel formed between the source and the drain, a gate insulating layer formed on the channel, and a source electrode and a drain electrode respectively connected with the source and the drain, a fluid line for covering the transistor to have an inner space together with the transistor and in which a sample solution including target molecules flows, a reference electrode formed on an inner wall of the fluid line, and a probe molecule layer attached on the reference electrode and reacting with the target molecules. Accordingly, the reference electrode is formed on the inner wall of the fluid line, enabling miniaturization of the bio device. Also, the probe molecules are formed on the reference electrode to measure a change in threshold voltage according to a change in electric potential between the reference electrode and the gate insulating layer, such that the sensitivity and reaction rate can be remarkably improved.

    摘要翻译： 提供了一种生物传感器及其驱动方法。 生物传感器包括晶体管，其包括基板，该基板包括源极，漏极和形成在源极和漏极之间的沟道，形成在沟道上的栅极绝缘层以及分别与源极和漏极连接的源极和漏极 漏极，用于覆盖晶体管的流体线，其与晶体管一起具有内部空间，并且其中包含目标分子的样品溶液流动，形成在流体管线的内壁上的参考电极和附着在该流体管线上的探针分子层 参考电极并与靶分子反应。 因此，参考电极形成在流体管线的内壁上，使生物装置能够小型化。 此外，探针分子形成在参考电极上，以根据参考电极和栅极绝缘层之间的电位的变化来测量阈值电压的变化，从而可以显着提高灵敏度和反应速率。