公开(公告)号：US20040122247A1

公开(公告)日：2004-06-24

申请号：US10720380

申请日：2003-11-25

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Thomas R. Boussie ,  Gary M. Diamond ,  Christopher Goh ,  Keith A. Hall ,  Anne M. Lapointe ,  Margarete K. Leclerc ,  Cheryl Lund ,  Vince Murphy

IPC: C07F001/00

CPC classification number: C07D213/74 ,  B01J2219/00722 ,  C07B2200/11 ,  C07D213/38 ,  C07D213/61 ,  C07D213/68 ,  C07F7/00 ,  C07F7/003 ,  C07F9/58 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C40B40/14 ,  C08F4/659 ,  C08F4/65904 ,  C08F2500/15 ,  C08F2500/02 ,  C08F210/10 ,  C08F212/08 ,  C08F210/14 ,  C08F4/64144 ,  C08F4/64113 ,  C08F4/64044

Abstract: New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.

Abstract translation: 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。

公开(公告)号：US20040121448A1

公开(公告)日：2004-06-24

申请号：US10325709

申请日：2002-12-20

Applicant: Symyx Technologies, Inc.

Inventor： Christopher Goh ,  Keith Anthony Hall ,  Thomas R. Boussie ,  Vince Murphy ,  Trevor G. Frank ,  William H. Chandler JR. ,  Lynn Van Erden

IPC: C12M001/34

CPC classification number: B01J3/04 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00315 ,  B01J2219/00353 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  B01J2219/00738 ,  C40B40/14 ,  C40B50/08 ,  C40B60/14 ,  Y10T436/2575

Abstract: An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries in a fixed position relative to the chamber and configured to form a sealed enclosure. An injection manifold is located within the reaction chamber and selectively movable relative to the libraries. The injection manifold is configured for receiving at least one fluid transfer line coupled to an external source for injection of one or more chemical components into the reaction chamber.

Abstract translation: 公开了将一种或多种化学成分注入反应室的装置和方法。 该装置包括反应室，用于接收相对于室的固定位置的一个或多个库，并构造成形成密封的外壳。 注射歧管位于反应室内并且可相对于库选择性地移动。 注入歧管被构造成用于接收至少一个连接到外部源的流体输送管线，用于将一种或多种化学成分注入反应室。

公开(公告)号：US20040110636A1

公开(公告)日：2004-06-10

申请号：US10641906

申请日：2003-08-15

Applicant: Symyx Technologies, Inc.

Inventor： Claus Lugmair ,  Alfred Hagemeyer ,  Lynn Van Erden ,  Anthony F. Volpe JR. ,  David M. Lowe ,  Yumin Liu

IPC: B01J023/02

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

Abstract translation: 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。

公开(公告)号：US20040014950A1

公开(公告)日：2004-01-22

申请号：US10421212

申请日：2003-04-23

Applicant: Symyx Technologies, Inc.

Inventor： Thomas R. Boussie ,  Oliver Brummer ,  Gary M. Diamond ,  Christopher Goh ,  Anne M. LaPointe ,  Margaret K. Leclerc ,  James A. W. Shoemaker

IPC: C07F009/02 ,  C07F005/00 ,  C07F007/28 ,  C07C395/00

CPC classification number: C08F10/00 ,  B01J31/223 ,  B01J31/2243 ,  B01J31/226 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2531/48 ,  B01J2531/49 ,  C07C37/055 ,  C07C37/62 ,  C07C39/367 ,  C07C41/16 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C215/74 ,  C07C217/80 ,  C07C323/20 ,  C07C2603/18 ,  C07C2603/24 ,  C07C2603/74 ,  C07D209/86 ,  C07F7/003 ,  C07F9/5022 ,  C08F4/65908 ,  C08F4/65912 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C08F212/08 ,  C08F4/6592 ,  C08F4/64186 ,  C08F2500/03 ,  C08F210/14 ,  C08F4/64196 ,  C08F4/64193 ,  C08F4/659 ,  C07C43/225 ,  C07C39/15 ,  C07C39/38 ,  C07C43/2055

Abstract: New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.

Abstract translation: 公开了具有桥连双芳族配体的新配体和组合物，其催化单体聚合成聚合物。 这些具有金属中心的催化剂具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，丙烯或苯乙烯。 催化剂还将丙烯聚合成全同立构聚丙烯。

公开(公告)号：US20030219906A1

公开(公告)日：2003-11-27

申请号：US10336605

申请日：2003-01-03

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Daniel M. Giaquinta ,  Martin Devenney ,  Keith A. Hall ,  Isy Goldwasser

IPC: G01N001/10

CPC classification number: C23C14/087 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00445 ,  B01J2219/00475 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00493 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/0065 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00702 ,  B01J2219/00707 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B01J2219/00756 ,  B82Y25/00 ,  B82Y30/00 ,  C01B13/185 ,  C01G51/006 ,  C01P2002/52 ,  C01P2004/54 ,  C01P2004/61 ,  C01P2004/84 ,  C01P2006/40 ,  C04B35/01 ,  C04B35/62218 ,  C09K11/08 ,  C09K11/7718 ,  C09K11/7774 ,  C09K11/7794 ,  C23C14/042 ,  C23C16/042 ,  C40B30/08 ,  C40B40/18 ,  C40B50/08 ,  C40B60/14 ,  C40B70/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/193 ,  H01F41/18 ,  H01F41/34 ,  Y10T436/11 ,  Y10T436/15 ,  Y10T436/20 ,  Y10T436/2575

Abstract: A combinatorial method for discovering or optimizing materials is disclosed. The method uses solution-based components that are mixed and dispensed into regions on a substrate for drying and/or heat-treating. The drying and/or heat-treating produces materials that can be tested for a desired property.

Abstract translation: 公开了用于发现或优化材料的组合方法。 该方法使用基于溶液的组分，其混合并分配到基底上的区域用于干燥和/或热处理。 干燥和/或热处理产生可以测试所需性质的材料。

公开(公告)号：US20030218467A1

公开(公告)日：2003-11-27

申请号：US10155207

申请日：2002-05-24

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson ,  Oleg Kolosov ,  Leonid Matsiev ,  Laura T. Mazzola ,  Mikhail Spitkovsky ,  John Gallipeo

IPC: G01R027/04 ,  G01R027/32

CPC classification number: G01N29/036 ,  B01J2219/00689 ,  B01J2219/00707 ,  G01G3/13 ,  G01N5/045 ,  G01N33/15 ,  G01N2291/0257

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

Abstract translation: 用于测量小样品量的质量的方法和装置。 该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。 该方法和装置考虑监测保持样品的谐振器的响应并将响应与样本中的质量变化相关联。

公开(公告)号：US20030190260A1

公开(公告)日：2003-10-09

申请号：US10116862

申请日：2002-04-05

Applicant: Symyx Technologies, Inc.

Inventor： Tony N. Wheeler ,  Lynn Van Erden ,  William H. Chandler JR. ,  Richard Tiede ,  Robert J. Saxton ,  Anil Guram

IPC: G01N035/00 ,  G01N035/04

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00722 ,  B01L7/00 ,  B01L9/06 ,  C40B40/14 ,  C40B50/08 ,  C40B60/14 ,  G01N2035/00376 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.

公开(公告)号：US20030161763A1

公开(公告)日：2003-08-28

申请号：US10348220

申请日：2003-01-21

Applicant: Symyx Technologies, Inc.

Inventor： Lynn Van Erden ,  William H. Chandler JR.

IPC: B01J019/00

CPC classification number: B01L3/5025 ,  B01J3/04 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00736 ,  G01N35/028

Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, an inlet port, and two or more reaction vessels within the pressure chamber. The inlet port is in fluid communication with the pressure chamber, and is used for pressurizing the pressure chamber from an external pressure source. Each of the two or more reaction vessels are in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the two or more reaction vessels can be simultaneously pressurized through common fluid communication with the pressure chamber. In addition, during at least a second reaction stage of operation, each of the two or more pressurized reaction vessels can be isolated from each other.

Abstract translation: 公开了一种合成和筛选材料的装置和方法。 根据本发明的一个方面，用于实现化学反应的并行批量反应器包括压力室，入口和压力室内的两个或更多个反应容器。 入口与压力室流体连通，用于从外部压力源对压力室进行加压。 两个或更多个反应容器中的每一个与压力室可分离流体连通，使得在操作的第一加压阶段期间，两个或更多个反应容器中的每一个可以通过与压力室的常见流体连通同时加压。 此外，在操作的至少第二反应阶段期间，两个或更多个加压反应容器中的每一个可以彼此隔离。

公开(公告)号：US20030141613A1

公开(公告)日：2003-07-31

申请号：US10313477

申请日：2002-12-06

Applicant: Symyx Technologies, Inc.

Inventor： Damian A. Hajduk ,  Oleg Kolosov

IPC: B05D001/40 ,  B29C031/00

CPC classification number: B01J19/0046 ,  C40B40/00

Abstract: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. The plurality of samples is then formed into a plurality of films. Thereafter, the plurality of films is plastically deformed. Preferably, the plurality of films is deformed into a configuration appropriate for testing of properties or characteristics of the samples.

Abstract translation: 提供了用于材料样品库的制备，分析或两者的快速通量方法。 根据该方法，提供多个样品。 然后将多个样品形成为多个膜。 此后，多个膜塑性变形。 优选地，多个膜变形成适于测试样品的性质或特性的构型。

公开(公告)号：US20030100120A1

公开(公告)日：2003-05-29

申请号：US10334099

申请日：2002-12-30

Applicant: Symyx Technologies, Inc.

Inventor： Youqi Wang ,  Peijun Cong ,  Tony N. Wheeler ,  Lynn Thomas Van Erden ,  H. Sam Bergh

IPC: G01N001/14

CPC classification number: G01N35/109 ,  G01N1/14 ,  G01N2035/00277 ,  Y10T436/11 ,  Y10T436/24 ,  Y10T436/2575 ,  Y10T436/25875

Abstract: A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product. At least a portion of the reaction product is withdrawn through the sampling probe and analyzed. The sampling probe is contacted with the substrate during at least a portion of the delivering, reacting and withdrawing steps.

Abstract translation: 用于取样反应产物的方法包括通过取样探针输送反应物以接触沉积在基底上的物质并使反应物反应形成反应产物。 反应产物的至少一部分通过取样探针取出并进行分析。 在至少一部分递送，反应和取出步骤期间，取样探针与基底接触。