公开(公告)号：US07264608B2

公开(公告)日：2007-09-04

申请号：US10008361

申请日：2001-12-05

Applicant: Daniel F. Bischof ,  Ying-Cheng Lo ,  Daniel Lynn ,  Bryan J Blickhan

Inventor： Daniel F. Bischof ,  Ying-Cheng Lo ,  Daniel Lynn ,  Bryan J Blickhan

IPC: A61M29/00 ,  A61M35/00

CPC classification number: A61M1/3681 ,  A01N1/02 ,  A01N1/0215 ,  A01N1/0263 ,  A61M1/0222 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/3683

Abstract: Systems and methods manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.

Abstract translation: 系统和方法在无菌，封闭的环境中手动处理血液和血液成分，这进一步调节血液成分以用于随后的病原体灭活过程。 系统和方法将随机供体血小板单元的手动收集与在长期储存和/或输血之前进行病原体灭活的较大治疗剂量的血小板相匹配。

公开(公告)号：US20050269250A1

公开(公告)日：2005-12-08

申请号：US11198804

申请日：2005-08-05

Applicant: William Cork ,  James Ulmes ,  Richard West ,  Ying-Cheng Lo ,  Mark Weber ,  Kyungyoon Min

Inventor： William Cork ,  James Ulmes ,  Richard West ,  Ying-Cheng Lo ,  Mark Weber ,  Kyungyoon Min

IPC: G01N33/48 ,  A61B5/00 ,  A61B5/145 ,  A61B19/02 ,  A61M1/02 ,  A61M1/36 ,  A61M1/38 ,  A61M37/00 ,  B01D17/00 ,  B01D37/00 ,  B01D61/00 ,  B01D61/22 ,  B01L99/00 ,  C02F1/00 ,  C12M1/34 ,  G01N33/49 ,  G01N33/50 ,  G01N35/00 ,  G01N35/08 ,  G06F20060101 ,  G06F1/00 ,  B01D17/12

CPC classification number: A61B5/14546 ,  A61B5/14557 ,  A61B5/417 ,  A61B50/13 ,  A61B2562/028 ,  A61M1/0209 ,  A61M1/3609 ,  A61M1/367 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/12 ,  A61M2205/33 ,  A61M2205/52 ,  A61M2230/20 ,  B01D61/22 ,  G01N33/491 ,  G01N33/5005 ,  G01N33/5094 ,  G01N35/08 ,  G01N2035/00237 ,  Y10T436/117497

Abstract: A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least one microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selected characteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.

公开(公告)号：US5836933A

公开(公告)日：1998-11-17

申请号：US666190

申请日：1996-06-19

Applicant: Anthony D. Buttitta ,  John M. Munsch ,  Ying-Cheng Lo ,  Marc Bellotti

Inventor： Anthony D. Buttitta ,  John M. Munsch ,  Ying-Cheng Lo ,  Marc Bellotti

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/10 ,  A61B19/00

CPC classification number: A61J1/10

Abstract: A parenteral fluid delivery bag having a line set formed integral with the bag, the line set being peelably releasable from the remainder of the bag so as to assume a deployed position adapted to enter into fluid communication with a patient. In an alternate embodiment, a plurality of bags connected by an integrally formed wye-junction are adapted for delivery to a patient and retrieval of fluid from a patient.

Abstract translation: 一种肠胃外流体输送袋，其具有与所述袋一体形成的线组，所述线组可从所述袋的其余部分可剥离地释放，以便呈现适于与患者进行流体连通的展开位置。 在替代实施例中，通过整体形成的Y形接头连接的多个袋适于递送到患者并从患者回收流体。

公开(公告)号：US5662144A

公开(公告)日：1997-09-02

申请号：US588216

申请日：1996-01-18

Applicant: Ying-Cheng Lo ,  Sanjay V. Odak ,  Rafael A. Castellanos

Inventor： Ying-Cheng Lo ,  Sanjay V. Odak ,  Rafael A. Castellanos

IPC: A61M39/08 ,  A61M39/28 ,  F16L11/12 ,  F16L11/04

CPC classification number: F16L11/121 ,  A61M39/08 ,  A61M39/28

Abstract: A tubing has members located on the inside surface of a tubing. The flow through the tubing is completely occluded when the tubing is clamped due to the members filling channels around the clamped site. Reduced clamping pressure is required to fully occlude the flow through the tubing. The tubing undergoes less deformation upon clamping and returns to its pre-clamped form upon recovery.

Abstract translation: 管道具有位于管道内表面上的构件。 当管道被夹紧时，通过管道的流动被完全封闭，因为构件在夹紧位置周围填充通道。 需要降低夹紧压力以完全堵塞通过管道的流动。 管道在夹紧时经历较小的变形，并在回收时恢复其预夹紧形式。

公开(公告)号：US5439454A

公开(公告)日：1995-08-08

申请号：US883001

申请日：1992-05-14

Applicant: Ying-Cheng Lo ,  Indrajit T. Patel ,  Lecon Woo ,  W. Wilson Cheung ,  Michael T. K. Ling

Inventor： Ying-Cheng Lo ,  Indrajit T. Patel ,  Lecon Woo ,  W. Wilson Cheung ,  Michael T. K. Ling

IPC: A61M5/14 ,  A61J1/10 ,  A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61M1/00 ,  A61M1/28 ,  A61M25/00 ,  B32B27/08 ,  A61M5/00 ,  B32B1/08 ,  F16L11/00

CPC classification number: C08L53/025 ,  A61L29/041 ,  A61L29/049 ,  A61M25/0045 ,  B32B27/08 ,  C08L23/142 ,  C08L53/02 ,  C08L2205/035 ,  C08L23/0853 ,  C08L27/06 ,  C08L67/00 ,  Y10T428/1393

Abstract: The present invention provides an improved coextruded medical port tubing. The medical port tubing provides characteristics that are desirable in the medical industry and therefore can be used as a medical port tubing in, for example, renal therapy or blood donor tubes. To this end, the present invention provides a coextruded medical grade port tubing comprising: an outer layer comprising a blend of polypropylene copolymer and styrene-ethylene-butylene-styrene copolymer; a tie layer; and a core layer comprising polyvinyl chloride.

Abstract translation: 本发明提供了一种改进的共挤压医用口管。 医用口管提供在医疗行业中所需的特征，因此可以用作例如肾脏治疗或献血管中的医疗口管。 为此，本发明提供了一种共挤出的医用级端口管，其包括：包含聚丙烯共聚物和苯乙烯 - 乙烯 - 丁烯 - 苯乙烯共聚物的共混物的外层; 一个领带; 以及包含聚氯乙烯的芯层。

公开(公告)号：US4877393A

公开(公告)日：1989-10-31

申请号：US277815

申请日：1988-11-30

Applicant: Ying-Cheng Lo

Inventor： Ying-Cheng Lo

IPC: B29C43/22 ,  B29C47/14 ,  B29C47/54 ,  B29C55/12 ,  B29C55/18 ,  B29C67/00

CPC classification number: B29C55/12 ,  B29C43/22 ,  B29C47/0023 ,  B29C47/14 ,  B29C47/54 ,  B29C55/18 ,  B29C67/0029 ,  B29K2995/0041 ,  B29K2995/0053

Abstract: In accordance with the apparatus for practicing the instant invention, biaxially oriented polymer sheet is produced by flowing and advancing a polymer workpiece between pairs of opposed working surfaces which converge in the "X" direction while diverging in the "Y" direction. The surfaces which converge in the "X" direction are provided with protruding working surfaces which squeeze the workpiece laterally as the workpiece advances longitudinally. The protruding working surfaces force the material of the workpiece to expand to the full width of the working surfaces while minimizing limitations due to friction between the surfaces of the die and the workpiece. In accordance with a first embodiment of the invention, the apparatus utilizes an extrusion die to effect the transformation of stock into flat sheet polymer material. In accordance with a second embodiment of the invention, the apparatus and process utilize a pair of opposed belts supported by convex rollers to effect the transformation of stock into sheet. The sheet produced by the process and apparatus has uniform strain distribution over the width thereof and through the thickness thereof.

Abstract translation: 根据实施本发明的装置，通过使聚合物工件在“Y”方向发散的同时在“X”方向收敛的成对的相对的工作表面之间流动和前进而制造双轴取向的聚合物片材。 会聚在“X”方向的表面设置有突出的工作表面，当工件纵向前进时横向挤压工件。 突出的工作表面迫使工件的材料膨胀到工作表面的整个宽度，同时最小化由于模具和工件的表面之间的摩擦而引起的限制。 根据本发明的第一实施例，该设备利用挤出模具来实现将坯料转变成平板聚合物材料。 根据本发明的第二实施例，该设备和工艺利用由凸辊支撑的一对相对的带，以实现将坯料转变成片。 通过该方法和装置制造的片材在其宽度上和通过其厚度具有均匀的应变分布。

公开(公告)号：US4789514A

公开(公告)日：1988-12-06

申请号：US806994

申请日：1985-12-09

Applicant: Ying-Cheng Lo

Inventor： Ying-Cheng Lo

IPC: B29C43/22 ,  B29C43/02 ,  B29C43/16 ,  B29C43/24 ,  B29C47/14 ,  B29C47/54 ,  B29C55/12 ,  B29C55/18 ,  B29C67/00 ,  B29K23/00 ,  B29L7/00

CPC classification number: B29C55/18 ,  B29C43/02 ,  B29C43/22 ,  B29C47/0023 ,  B29C47/14 ,  B29C47/54 ,  B29C55/12 ,  B29C67/0029 ,  B29K2995/0041 ,  B29K2995/0053 ,  Y10S428/91

Abstract: In accordance with the process of and apparatus for practicing the instant invention, biaxially oriented polymer sheet is produced by flowing and advancing a polymer workpiece between pairs of opposed working surfaces which converge in the "X" direction while diverging in the "Y" direction. The surfaces which converge in the "X" direction are provided with protruding working surfaces which squeeze the workpiece laterally as the workpiece advances longitudinally. The protruding working surfaces force the material of the workpiece to expand to the full width of the working surfaces while minimizing limitations due to friction between the surfaces of the die and the workpiece. In accordance with a first embodiment of the invention, the apparatus and process utilize an extrusion die to effect the transformation of stock into flat sheet polymer material. In accordance with a second embodiment of the invention, the apparatus and process utilize a pair of opposed belts supported by convex rollers to effect the transformation of stock into sheet. The sheet produced by the process and apparatus has uniform strain distribution over the width thereof and through the thickness thereof.

Abstract translation: 根据实施本发明的方法和设备，通过使聚合物工件在“Y”方向发散的同时在“X”方向收敛的相对的工作表面之间流动和推进聚合物工件来生产双轴取向聚合物片材。 会聚在“X”方向的表面设置有突出的工作表面，当工件纵向前进时横向挤压工件。 突出的工作表面迫使工件的材料膨胀到工作表面的整个宽度，同时最小化由于模具和工件的表面之间的摩擦而引起的限制。 根据本发明的第一实施例，该设备和方法利用挤出模具来实现将坯料转变成平板聚合物材料。 根据本发明的第二实施例，该设备和工艺利用由凸辊支撑的一对相对的带，以实现将坯料转变成片。 通过该方法和装置制造的片材在其宽度上和通过其厚度具有均匀的应变分布。

公开(公告)号：US09348975B2

公开(公告)日：2016-05-24

申请号：US12431458

申请日：2009-04-28

Applicant: Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

Inventor： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

IPC: G06F19/00 ,  A61M1/28

CPC classification number: G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

Abstract: Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

Abstract translation: 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果，观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰值停留时间。

公开(公告)号：US08764981B2

公开(公告)日：2014-07-01

申请号：US13296522

申请日：2011-11-15

Applicant: Yuanpang Samuel Ding ,  Ying-Cheng Lo

Inventor： Yuanpang Samuel Ding ,  Ying-Cheng Lo

IPC: B01D61/30 ,  A61M1/14 ,  A61M37/00 ,  A61M1/28 ,  A61M1/16

CPC classification number: B01D61/30 ,  A61M1/1696 ,  A61M1/284 ,  A61M1/287

Abstract: Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

Abstract translation: 提供了用于从透析废物流中除去尿素的透析治疗装置和方法。 在一般实施例中，本发明提供一种透析治疗装置，其包括：1）具有过滤膜的第一过滤器，2）具有脲酶并与第一过滤器流体连通的尿素去除单元，以及3）具有 离子排斥膜并与第一过滤器和尿素去除单元流体连通。

公开(公告)号：US20120055864A1

公开(公告)日：2012-03-08

申请号：US13296522

申请日：2011-11-15

Applicant: Yuanpang Samuel Ding ,  Ying-Cheng Lo

Inventor： Yuanpang Samuel Ding ,  Ying-Cheng Lo

IPC: B01D61/24

CPC classification number: B01D61/30 ,  A61M1/1696 ,  A61M1/284 ,  A61M1/287

Abstract: Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

Abstract translation: 提供了用于从透析废物流中除去尿素的透析治疗装置和方法。 在一般实施例中，本发明提供一种透析治疗装置，其包括：1）具有过滤膜的第一过滤器，2）具有脲酶并与第一过滤器流体连通的尿素去除单元，以及3）具有 离子排斥膜并与第一过滤器和尿素去除单元流体连通。