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公开(公告)号：US4957744A
公开(公告)日：1990-09-18
申请号：US106658
申请日：1987-10-13
IPC分类号： A61K9/70 , A61K8/00 , A61K8/11 , A61K8/72 , A61K8/73 , A61K8/96 , A61K9/48 , A61K9/62 , A61K47/00 , A61K47/36 , A61L15/16 , A61L15/28 , A61L17/10 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/08 , C08L5/00 , C08L5/08
CPC分类号： A61K31/715 , A61K47/36 , A61K8/735 , A61L15/28 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0072 , Y10S514/844 , Y10S514/88
摘要： Cross-linked esters of hyaluronic acid are provided which result from the esterification of polyhydric alcohols with two or more carboxy groups of the hyaluronic acid polysaccharide. These cross-linked esters are useful in the field of biodegradable plastics for sanitary and surgical articles and in the pharmaceutical and cosmetic fields for the preparation of useful compositions and articles.
摘要翻译： 提供透明质酸的交联酯，其由多元醇与透明质酸多糖的两个或更多个羧基的酯化反应而产生。 这些交联酯可用于卫生和外科用品的可生物降解塑料领域，并且在制药和化妆品领域中用于制备有用的组合物和制品。
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公开(公告)号：US4897382A
公开(公告)日：1990-01-30
申请号：US209565
申请日：1988-06-21
IPC分类号： A61K31/16 , A61K31/165 , A61K31/195 , A61K31/435 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/48 , A61K31/52 , A61K31/522 , A61K31/66 , A61K31/675 , A61K31/70 , A61K31/7028 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C233/18 , C07C233/71 , C07C235/48 , C07C235/52 , C07C237/08 , C07C237/12 , C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/58 , C07H15/04 , C07H15/10 , C07H15/18 , C07H15/26
CPC分类号： C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/091 , C07F9/10 , C07F9/113 , C07F9/588 , C07H15/10 , C07H15/18 , C07H15/26
摘要： Organic amide compounds of the formula ##STR1## wherein R.sub.1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen of nitrogenous lipids, R.sub.2 is a hydrogen atom, a C.sub.1-7 alkyl group, or a C.sub.4-7 cycloalkyl group, and R.sub.3-N is a residue of a nitrogenous lipid. The compounds are useful in increasing or stimulating the in vivo biological activity of in vitro biologically active carboxylic acids.
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公开(公告)号：US06407072B1
公开(公告)日：2002-06-18
申请号：US08268730
申请日：1994-06-30
IPC分类号： A61K3170
CPC分类号： C07H15/10
摘要： Novel N-acyl-lysogangliosides obtained from gangliosides by deacyation of the ceramide group, wherein the acyl group is derived from an aliphatic acid having from 2 to 24 carbon atoms, substituted by one or more polar groups. The N-acyl-lysogangliosides of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.
摘要翻译： 通过神经酰胺基去酰化从神经节苷脂获得的新型N-酰基 - 溶血杆菌二糖苷，其中酰基衍生自具有2至24个碳原子的脂族酸，被一个或多个极性基团取代。 本发明的N-酰基 - 溶血杆菌二糖苷对蛋白激酶C活化具有抑制作用，因此可用于神经系统各种病理学的治疗。
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24.发明授权Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same 失效具有药物活性的透明质酸馏分和含有它们的药物组合物
公开(公告)号：US5925626A
公开(公告)日：1999-07-20
申请号：US471016
申请日：1995-06-06
IPC分类号： C08B37/08 , A61K20060101 , A61K9/00 , A61K9/08 , A61K31/715 , A61K38/18 , A61K45/06 , A61K47/36 , A61P17/00 , A61P27/02 , A61P29/00 , A61P43/00 , C07C20060101 , C08B33/08 , C12S3/02 , A61K31/70 , C07H5/04
CPC分类号： A61K9/0014 , A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/36 , A61K9/0019 , A61K9/0048 , C08B37/0072
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。
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公开(公告)号：US5792858A
公开(公告)日：1998-08-11
申请号：US628344
申请日：1996-04-05
IPC分类号： A61K31/16 , A61K31/275 , A61K31/685 , A61K31/70 , A61K31/7028 , A61P25/00 , A61P25/28 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/04 , C07H15/10 , C07H11/00 , C07F9/02
CPC分类号： C07H15/04 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/10
摘要： Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: ##STR1## in which -A- stands for the group --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, n.sub.1 is a whole number of between 6 and 18, n.sub.2 is a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.
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26.发明授权Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration 失效用于神经治疗和再生的可生物降解和生物可吸收的引导通道
公开(公告)号：US5735863A
公开(公告)日：1998-04-07
申请号：US104025
申请日：1994-05-24
IPC分类号： A61L31/00 , A61B17/11 , A61F2/00 , A61F2/02 , A61F2/04 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/16 , A61B17/00
CPC分类号： A61L31/148 , A61L31/042 , A61L31/129 , A61B17/1128 , A61F2/0077 , A61F2/04 , A61F2210/0004 , A61L2430/32
摘要： The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded in a matrix and coextruded with active factors wherein both the matrix and the threads are comprised of biocompatible and bioabsorbable esters of hyaluronic acid.
摘要翻译： PCT No.PCT / EP92 / 00285 Sec。 371日期：1994年5月24日 102（e）日期1994年5月24日PCT提交1992年2月10日PCT公布。 出版物WO92 / 13579 日本1992年8月20日本发明涉及由可用于修复和再生神经组织的生物可降解导向通道构成的医疗器械。 引导通道由嵌入基质中的螺纹组成并与活性因子共挤出，其中基质和螺纹均由透明质酸的生物相容性和生物可吸收的酯组成。
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公开(公告)号：US5676964A
公开(公告)日：1997-10-14
申请号：US465055
申请日：1995-06-05
IPC分类号： C08B3/00 , A61K8/02 , A61K8/73 , A61K47/36 , A61K47/38 , A61L15/28 , A61L15/42 , A61L17/10 , A61L27/20 , A61L27/58 , A61L31/04 , A61Q19/00 , C08B11/00 , C08B11/20 , C08B13/00 , C08B15/00 , C08B15/10 , C08B37/00 , C08B37/08 , C08L101/16 , A61F2/00 , A61K31/70 , C07H5/04
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/38 , A61K8/0208 , A61K8/73 , A61K8/731 , A61K8/733 , A61K8/735 , A61K8/736 , A61L15/28 , A61L15/425 , A61L17/10 , A61L27/20 , A61L27/58 , A61L31/042 , A61Q19/00 , C08B11/20 , C08B15/005 , C08B37/003 , C08B37/0072 , C08B37/0084 , A61K2800/57
摘要： Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acids are useful in the field of biodegradable plastic materials, to manufacture sanitary and surgical articles, in the cosmetic and pharmaceutical fields, in the food industry and in many other industrial fields.
摘要翻译： 公开了酸多糖的间和/或分子内交联的酯，其中部分或全部羧基用同一分子的羟基和/或酸多糖的不同分子酯化。 这些多糖酸的内部交联酯可用于可生物降解的塑料材料领域，在食品工业和许多其他工业领域的化妆品和制药领域中制造卫生和外科用品。
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公开(公告)号：US5484775A
公开(公告)日：1996-01-16
申请号：US96853
申请日：1993-07-26
IPC分类号： C07H15/04 , A61K31/70 , A61K31/7028 , A61P9/10 , A61P25/00 , A61P25/28 , C07H15/10 , A61K31/715 , C07H5/04
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-dilysogangliosides, wherein the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 11 carbon atoms, and N'-acyl-N,N'-dilysogangliosides and N,N'-di-acyl-N,N'-dilysogangliosides, in which the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 24 carbon atoms (with the exception of certain acetyl and diacetyl derivatives). The compounds of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.
摘要翻译： N-酰基-N，N'-二糖二糖二糖苷，其中酰基衍生自具有1至11个碳原子的未取代的脂族酸，和N' - 酰基-N，N'-二糖二糖二糖苷和N，N'-二酰基 其中酰基衍生自具有1至24个碳原子的未取代的脂族酸（除了某些乙酰基和二乙酰基衍生物）。 本发明的化合物对蛋白激酶C活化具有抑制作用，因此可用于治疗神经系统的各种病理学。 还公开了溶血二糖苷衍生物的药物组合物和治疗用途。
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公开(公告)号：US5466461A
公开(公告)日：1995-11-14
申请号：US862370
申请日：1992-04-02
IPC分类号： C08B3/00 , A61K8/73 , A61K47/36 , A61K47/38 , A61K47/48 , A61L15/28 , A61L15/42 , A61L17/10 , A61L27/20 , A61L31/04 , A61Q19/00 , C08B11/00 , C08B11/12 , C08B13/00 , C08B15/10 , C08B31/12 , C08B37/00 , C08B37/08 , A61F13/15 , A61K9/08 , A61K9/48
CPC分类号： A61K9/0019 , A61K31/715 , A61K47/36 , A61K47/38 , A61K47/4823 , A61K8/731 , A61K8/732 , A61K8/736 , A61K9/0014 , A61L15/28 , A61L15/425 , A61L17/10 , A61L27/20 , A61L31/042 , A61Q19/00 , C08B11/12 , C08B31/12 , C08B37/003 , A61K2800/5424 , Y10S424/15 , Y10S514/912 , Y10S514/953 , Y10S514/96 , Y10S514/962 , Y10S514/965 , Y10S514/969 , Y10S604/904
摘要： New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.
摘要翻译： 公开了新的多糖酯，更确切地说，选自羧甲基纤维素，羧甲基淀粉和羧甲基壳蛋白形成的基团中的酸性多糖的酯。 这些新的酯类和一些已知类型的酯可用作制药和化妆品制剂的药物，在可生物降解的塑料材料领域中，因此用于制造医疗，外科和卫生用品，以及 许多其他工业部门现在常常使用酸性多糖。
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30.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5326356A
公开(公告)日：1994-07-05
申请号：US19818
申请日：1993-02-16
IPC分类号： A61L27/00 , A61F2/10 , A61K35/12 , A61L27/60 , C12N5/00 , C12N5/071 , A61F2/02 , A61F2/54 , A61F13/00
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells. Artificial skins obtained thereby and its use in grafts are also provided.
摘要翻译： 提供由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于含有10至1000微米之间的恒定尺寸的有序系列的孔，彼此分开通过 通过机械，热激光或紫外线辐射手段穿孔获得50至1000微米的恒定距离，它们适合用作上皮细胞体外生长的载体。 还提供了由此获得的人造皮肤及其在移植物中的用途。
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