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公开(公告)号:US20230255597A1
公开(公告)日:2023-08-17
申请号:US17903999
申请日:2022-09-06
CPC分类号: A61B8/481 , A61N7/02 , A61B8/0808 , A61N2007/0095
摘要: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
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公开(公告)号:US20230240660A1
公开(公告)日:2023-08-03
申请号:US18132086
申请日:2023-04-07
申请人: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. , GENERAL HOSPITAL OF CHINESE PLA , SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
发明人: Yukun LUO , Xiang FEI , Xirui ZHANG , Maodong SANG , Lei ZHU , Yuxin CHEN , Yan ZHANG , Fang XIE , Yiru WANG , Duo DONG
CPC分类号: A61B8/5207 , A61B8/06 , A61B8/461 , A61B8/481
摘要: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also be provided.
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公开(公告)号:US11672512B2
公开(公告)日:2023-06-13
申请号:US16883884
申请日:2020-05-26
申请人: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. , GENERAL HOSPITAL OF CHINESE PLA , SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
发明人: Yukun Luo , Xiang Fei , Xirui Zhang , Maodong Sang , Lei Zhu , Yuxin Chen , Yan Zhang , Fang Xie , Yiru Wang , Duo Dong
CPC分类号: A61B8/5207 , A61B8/06 , A61B8/461 , A61B8/481
摘要: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also provided.
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公开(公告)号:US20190192113A1
公开(公告)日:2019-06-27
申请号:US16330048
申请日:2017-09-01
发明人: Mahender nath Avula , Douglas A. Christensen , Navid Farhoudi , Stan Kanarowski , Julia Koerner , Jules John Magda , Rami Sami Marrouche , Christopher F. Reiche , Florian Solzbacher , Michael David Sorenson
CPC分类号: A61B8/0841 , A61B8/12 , A61B8/481 , A61B90/39 , A61B2090/3929
摘要: Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.
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25.
公开(公告)号:US20190192112A1
公开(公告)日:2019-06-27
申请号:US16042294
申请日:2018-07-23
发明人: Elisa E. Konofagou , Tobias Teichert , Vincent P. Ferrera , Fabrice Marquet , Yao-Sheng Tung , Shih-Ying Wu
CPC分类号: A61B8/0808 , A61B8/4281 , A61B8/481 , A61B8/5223 , A61B2090/378 , A61N7/02 , A61N2007/0039 , A61N2007/0052 , A61N2007/0091
摘要: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.
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公开(公告)号:US20190184204A1
公开(公告)日:2019-06-20
申请号:US16322437
申请日:2017-07-31
发明人: Bhaskar Ramamurthy
CPC分类号: A61N7/00 , A61B8/06 , A61B8/08 , A61B8/0816 , A61B8/145 , A61B8/4461 , A61B8/466 , A61B8/469 , A61B8/481 , A61B8/5207 , A61B8/5261 , A61B9/00 , A61N7/02 , A61N2007/0021 , A61N2007/0039 , A61N2007/0052 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095
摘要: A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier, Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.
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公开(公告)号:US20180353738A1
公开(公告)日:2018-12-13
申请号:US16108525
申请日:2018-08-22
CPC分类号: A61M31/005 , A61B5/055 , A61B6/032 , A61B8/481 , A61B10/04 , A61B90/39 , A61B2090/3908 , A61B2090/3912 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3983 , A61B2090/3987 , A61B2090/3991 , A61B2090/3995
摘要: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
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公开(公告)号:US20180276821A1
公开(公告)日:2018-09-27
申请号:US15989457
申请日:2018-05-25
发明人: Liang Lin , Qingxing Cao , Qing Wang , Bo Jiang
IPC分类号: G06T7/00 , G06K9/32 , G06K9/62 , G06T7/62 , G06T7/70 , G06K9/46 , G06K9/34 , A61B8/08 , A61B8/00
CPC分类号: G06T7/0014 , A61B8/085 , A61B8/469 , A61B8/481 , A61B8/5223 , G06K9/3233 , G06K9/3241 , G06K9/346 , G06K9/4604 , G06K9/4671 , G06K9/6227 , G06K9/6257 , G06K9/6276 , G06K9/6289 , G06K2209/05 , G06T7/0016 , G06T7/62 , G06T7/70 , G06T2207/10132 , G06T2207/20072 , G06T2207/20076 , G06T2207/20081 , G06T2207/30056 , G06T2207/30096
摘要: The disclosure relates to a method for automatically recognizing liver tumor types in ultrasound images. The method specifically comprises: using a plurality of Regions of Interest (ROIs) to represent a CEUS image; different lesions are distinguished by the performance and changes of the ROI in time and space; representing a space-time relationship between ROIs by establishing a model in time and space at the same time; and determining, by the model, a relatively appropriate ROI and relevant parameters of the model according to existing CEUS lesion samples by means of an iterative learning method. After giving a sample, an appropriate ROI can be determined and a reference diagnosis for the lesion can be given by removing part of inappropriate ROIs in advance and by means of a rapid search method.
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29.
公开(公告)号:US10080614B2
公开(公告)日:2018-09-25
申请号:US14984986
申请日:2015-12-30
申请人: HeartFlow, Inc.
发明人: Charles A. Taylor
IPC分类号: A61B6/00 , A61B34/10 , G06F17/10 , A61B34/00 , A61B5/02 , A61B5/026 , G06G7/60 , G06F19/26 , A61B5/00 , A61B5/029 , A61B6/03 , A61B8/06 , A61B8/08 , G01R33/563 , A61B5/107 , G06T7/00 , G06T17/00 , G06K9/00 , G06K9/62 , A61B5/021 , G06F17/50 , G06F19/12 , A61B5/024 , A61B5/22 , G06F19/00 , G06K9/46 , G06T7/20 , G06T11/00 , G06T11/20 , A61M5/00 , G06K9/52 , A61B5/055 , A61B5/11 , G06T17/20 , G06T15/10 , G06T11/60 , G06T7/60 , A61B8/02 , A61B8/04 , G06T7/70 , G06T7/73 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/62 , G01R33/56 , G16H10/60 , G16H50/30 , G16H50/50 , A61B90/00
CPC分类号: A61B34/10 , A61B5/0035 , A61B5/004 , A61B5/0044 , A61B5/02 , A61B5/02007 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/026 , A61B5/0263 , A61B5/029 , A61B5/055 , A61B5/1075 , A61B5/1118 , A61B5/22 , A61B5/4848 , A61B5/6852 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/745 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , A61B6/5205 , A61B6/5217 , A61B6/5229 , A61B8/02 , A61B8/04 , A61B8/06 , A61B8/065 , A61B8/481 , A61B8/5223 , A61B8/5261 , A61B34/25 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2090/374 , A61B2090/3762 , A61B2090/3764 , A61B2576/00 , A61B2576/023 , A61M5/007 , G01R33/5601 , G01R33/5635 , G01R33/56366 , G06F17/10 , G06F17/5009 , G06F17/5018 , G06F19/00 , G06F19/321 , G06F19/324 , G06G7/60 , G06K9/00147 , G06K9/46 , G06K9/4604 , G06K9/52 , G06K9/6215 , G06K9/6267 , G06K9/6298 , G06K2009/4666 , G06T7/0012 , G06T7/0014 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/70 , G06T7/73 , G06T7/74 , G06T11/00 , G06T11/001 , G06T11/008 , G06T11/20 , G06T11/60 , G06T15/10 , G06T17/00 , G06T17/005 , G06T17/20 , G06T2200/04 , G06T2207/10012 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20036 , G06T2207/20124 , G06T2207/30048 , G06T2207/30104 , G06T2210/41 , G06T2211/404 , G16B5/00 , G16B45/00 , G16H10/40 , G16H10/60 , G16H30/20 , G16H30/40 , G16H50/30 , G16H50/50 , G16H50/70 , Y02A90/22 , Y02A90/26
摘要: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
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30.
公开(公告)号:US10052158B2
公开(公告)日:2018-08-21
申请号:US14985731
申请日:2015-12-31
申请人: HeartFlow, Inc.
发明人: Charles A. Taylor
IPC分类号: G06K9/00 , A61B34/10 , G06F17/10 , A61B34/00 , A61B5/02 , A61B5/026 , G06G7/60 , G06F19/26 , A61B5/00 , A61B5/029 , A61B6/03 , A61B6/00 , A61B8/06 , A61B8/08 , G01R33/563 , A61B5/107 , G06T7/00 , G06T17/00 , G06K9/62 , A61B5/021 , G06F17/50 , G06F19/12 , A61B5/024 , A61B5/22 , G06F19/00 , G06K9/46 , G06T7/20 , G06T11/00 , G06T11/20 , A61M5/00 , G06K9/52 , A61B5/055 , A61B5/11 , G06T17/20 , G06T15/10 , G06T11/60 , G06T7/60 , A61B8/02 , A61B8/04 , G06T7/70 , G06T7/73 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/62 , G01R33/56 , G16H10/60 , G16H50/30 , G16H50/50 , A61B90/00
CPC分类号: A61B34/10 , A61B5/0035 , A61B5/004 , A61B5/0044 , A61B5/02 , A61B5/02007 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/026 , A61B5/0263 , A61B5/029 , A61B5/055 , A61B5/1075 , A61B5/1118 , A61B5/22 , A61B5/4848 , A61B5/6852 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/745 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , A61B6/5205 , A61B6/5217 , A61B6/5229 , A61B8/02 , A61B8/04 , A61B8/06 , A61B8/065 , A61B8/481 , A61B8/5223 , A61B8/5261 , A61B34/25 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2090/374 , A61B2090/3762 , A61B2090/3764 , A61B2576/00 , A61B2576/023 , A61M5/007 , G01R33/5601 , G01R33/5635 , G01R33/56366 , G06F17/10 , G06F17/5009 , G06F17/5018 , G06F19/00 , G06F19/321 , G06F19/324 , G06G7/60 , G06K9/00147 , G06K9/46 , G06K9/4604 , G06K9/52 , G06K9/6215 , G06K9/6267 , G06K9/6298 , G06K2009/4666 , G06T7/0012 , G06T7/0014 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/70 , G06T7/73 , G06T7/74 , G06T11/00 , G06T11/001 , G06T11/008 , G06T11/20 , G06T11/60 , G06T15/10 , G06T17/00 , G06T17/005 , G06T17/20 , G06T2200/04 , G06T2207/10012 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20036 , G06T2207/20124 , G06T2207/30048 , G06T2207/30104 , G06T2210/41 , G06T2211/404 , G16B5/00 , G16B45/00 , G16H10/40 , G16H10/60 , G16H30/20 , G16H30/40 , G16H50/30 , G16H50/50 , G16H50/70 , Y02A90/22 , Y02A90/26
摘要: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
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