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公开(公告)号：US20130000420A1
公开(公告)日：2013-01-03
申请号：US13512092
申请日：2010-11-26
Applicant: Otto Manneberg , Martin Wiklund , Björn Önfelt , Thomas Frisk , Hans M. Hertz , Bruno Vanherberghen
Inventor： Otto Manneberg , Martin Wiklund , Björn Önfelt , Thomas Frisk , Hans M. Hertz , Bruno Vanherberghen
IPC: G01N1/28
CPC classification number: B01J19/0046 , B01J2219/00315 , B01J2219/00486 , B01L3/5085 , B01L2200/0647 , B01L2400/0436 , B01L2400/0439
Abstract: A method for simultaneously merging suspended particles and/or cells in a plurality of discrete microwells, each of said microwells having at least a bottom wall and lateral walls, wherein a multifrequency or broadband acoustic wave including at least two different frequencies is applied to an inner volume of each of said microwells, the frequencies of said acoustic wave being selected to generate a standing and/or stationary wave in said volume; a device for simultaneously merging suspended particles and/or cells in a plurality of discrete microwells, including: a substrate with a plurality of discrete microwells, each of said microwells having at least a bottom wall and lateral walls; and one or more acoustic transducer(s), configured for applying a multifrequency or broadband acoustic wave, including at least two different frequencies, to an inner volume of each of said microwells.
Abstract translation: 一种用于在多个离散微孔中同时合并悬浮颗粒和/或细胞的方法，每个所述微孔具有至少一个底壁和侧壁，其中包括至少两个不同频率的多频或宽带声波被施加到内部 每个所述微孔的体积，所述声波的频率被选择以在所述体积中产生静止和/或静止波; 用于同时将多个离散微孔中的悬浮颗粒和/或细胞并入的装置，包括：具有多个离散微孔的基底，每个所述微孔至少具有底壁和侧壁; 以及一个或多个声学换能器，被配置为将多频或宽带声波（包括至少两个不同的频率）施加到每个所述微孔的内部体积。
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公开(公告)号：US08263005B2
公开(公告)日：2012-09-11
申请号：US11894805
申请日：2007-08-20
Applicant: James A. Laugharn, Jr. , Brevard S. Garrison , Robert Mcknight , Douglas A. Yates
Inventor： James A. Laugharn, Jr. , Brevard S. Garrison , Robert Mcknight , Douglas A. Yates
CPC classification number: B01F13/0059 , B01F11/02 , B01F11/0283 , B01F13/0222 , B01F13/0277 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/0046 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L2400/0436 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
Abstract: The present invention provides systems, methods, and devices for using acoustic energy.
Abstract translation: 本发明提供了用于使用声能的系统，方法和装置。
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公开(公告)号：US20090034360A1
公开(公告)日：2009-02-05
申请号：US11910420
申请日：2006-04-07
Applicant: Paul Mun Foo Tho , Richard Manasseh , Yonggang Zhu , Guy Metcalfe
Inventor： Paul Mun Foo Tho , Richard Manasseh , Yonggang Zhu , Guy Metcalfe
IPC: B01F11/02
CPC classification number: B01F11/02 , B01F11/0266 , B01F13/0059 , B01J2219/00486 , B01J2219/00889 , B01L3/5085
Abstract: A method of mixing (10), including: providing a fluid (10) in a well (6) so as to establish an acoustic field gradient; and applying an acoustic signal to cause mixing within a fluid (3).
Abstract translation: 一种混合（10）的方法，包括：在井（6）中提供流体（10）以便建立声场梯度; 以及施加声信号以在流体（3）内引起混合。
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公开(公告)号：US20080031094A1
公开(公告)日：2008-02-07
申请号：US11888708
申请日：2007-08-01
Applicant: James Laugharn , Brevard Garrison , Douglas Yates
Inventor： James Laugharn , Brevard Garrison , Douglas Yates
IPC: H04B1/02
CPC classification number: C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
Abstract: This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
Abstract translation: 本发明涉及向样品施加声能的系统和方法。 根据本发明的一个方面，一种系统包括壳体，用于接收样品的腔室，用于根据治疗方案向样品提供聚焦声场的声能源，用于确定治疗方案的处理器，传感器 用于检测关于样本的信息，以及用于与用户通信的用户界面。
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公开(公告)号：US20060158956A1
公开(公告)日：2006-07-20
申请号：US11295372
申请日：2005-12-05
Applicant: James Laugharn , Brevard Garrison , Robert McKnight , Douglas Yates
Inventor： James Laugharn , Brevard Garrison , Robert McKnight , Douglas Yates
IPC: B01F11/02
CPC classification number: B01F13/0059 , B01F11/02 , B01F11/0283 , B01F13/0222 , B01F13/0277 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/0046 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L2400/0436 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
Abstract: The present invention provides systems, methods, and devices for using acoustic energy.
Abstract translation: 本发明提供了用于使用声能的系统，方法和装置。
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Patent Agency Ranking
公开(公告)号：US20050235740A1
公开(公告)日：2005-10-27
申请号：US11115495
申请日：2005-04-27
Applicant: Guido Desie , Luc Vanmaele , Geert Deroover
Inventor： Guido Desie , Luc Vanmaele , Geert Deroover
CPC classification number: C09B67/0091 , B01J19/0046 , B01J2219/00308 , B01J2219/00315 , B01J2219/00481 , B01J2219/00486 , B01J2219/00691 , B01J2219/00702 , B01J2219/00756 , C40B60/14
Abstract: In a combinatorial method of making and testing an array of nanoparticle formulations comprising the steps of making multi-compositional formulations; improving the dispersion quality of these formulations by high speed parallel homogenizing; rapid serial, semi-parallel or parallel characterising said formulations, said step of high speed parallel homogenizing proceeds by providing energy to said dispersion via an array of tips, wherein said energy is ultrasonic energy or high shear mixing energy.
Abstract translation: 在制备和测试纳米颗粒制剂阵列的组合方法中，包括制备多组分制剂的步骤; 通过高速平行均化提高这些制剂的分散质量; 快速串联，半平行或平行表征所述制剂，所述高速平行均质化步骤通过经由尖端阵列向所述分散体提供能量而进行，其中所述能量是超声波能量或高剪切混合能量。
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27.发明申请Systems and methods for determining a state of fluidization and/or a state of mixing 有权用于确定流化状态和/或混合状态的系统和方法公开(公告)号：US20050150830A1
公开(公告)日：2005-07-14
申请号：US11006002
申请日：2004-12-07
Applicant: James Laugharn , Brevard Garrison
Inventor： James Laugharn , Brevard Garrison
CPC classification number: B01F13/0277 , B01F11/02 , B01F11/0283 , B01F13/0059 , B01F13/0222 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J2219/00317 , B01J2219/00486 , B01J2219/00659 , C12M35/04 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
Abstract: Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.
Abstract translation: 公开了用于通过选择性地控制声能和/或选择性地控制样品相对于声能的位置来处理样品的装置和方法。
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公开(公告)号：US5962338A
公开(公告)日：1999-10-05
申请号：US87028
申请日：1998-05-29
Applicant: Irving Sucholeiki
Inventor： Irving Sucholeiki
IPC: B01F11/02 , B01F13/08 , B01J19/00 , B06B3/02 , C07K1/04 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/543 , A61K38/00
CPC classification number: B06B3/02 , B01F11/0283 , B01F13/0809 , B01J19/0046 , C07K1/042 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/00328 , B01J2219/00351 , B01J2219/00414 , B01J2219/00454 , B01J2219/00459 , B01J2219/00486 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00686 , B01J2219/00691 , B01J2219/0072 , B01J2219/00725 , C40B40/10 , C40B50/14 , C40B60/14 , Y10S436/809 , Y10T436/25375
Abstract: A method of using a reaction plenum in the presence or absence of paramagnetic beads to perform chemical syntheses resulting in separation and recovery of a final desired reaction product is provided. The reaction plenum comprises a reaction plate, a reaction vessel for mounting in the reaction plate, a reaction plate holder, a screw-like rod, a mounting block attached to the reaction plate holder for operably receiving the screw-like rod, a motor, a sonication region in a temperature controllable water bath and a magnetic separation region in the water bath. Paramagnetic beads having reaction sites are introduced into the reaction vessels along with the appropriate solvent and one or more reactants. The contents of the reaction vessel are sonicated, then moved to the magnetic separation region where the paramagnetic beads are tightly held against the reaction vessel while the solvent is aspirated off. Once the desired reaction product is attained, the reaction product is cleaved off the paramagnetic bead. In an alternative embodiment, chemical synthesis is performed in a similar manner in the absence of the paramagnetic beads.
Abstract translation: 提供在存在或不存在顺磁珠的情况下使用反应室的方法进行导致分离和回收最终所需反应产物的化学合成。 反应室包括反应板，用于安装在反应板中的反应容器，反应板保持器，螺杆状杆，安装在反作用板保持器上用于可操作地接收螺杆状杆的安装块，马达， 在温度可控的水浴中的超声处理区域和水浴中的磁分离区域。 具有反应位点的顺磁珠与合适的溶剂和一种或多种反应物一起引入反应容器中。 将反应容器的内容物进行超声处理，然后移动到磁性分离区域，其中顺磁珠紧紧地保持在反应容器上，同时吸出溶剂。 一旦达到所需的反应产物，反应产物就从顺磁珠上分离出来。 在替代实施方案中，在不存在顺磁珠的情况下以类似的方式进行化学合成。
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29.发明授权公开(公告)号：US08999704B2
公开(公告)日：2015-04-07
申请号：US13186858
申请日：2011-07-20
Applicant: James A. Laugharn, Jr.
Inventor： James A. Laugharn, Jr.
CPC classification number: C12N13/00 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N1/286 , G01N2035/00554
Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。
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30.发明申请公开(公告)号：US20120015419A1
公开(公告)日：2012-01-19
申请号：US13186858
申请日：2011-07-20
Applicant: James A. Laugharn, JR.
Inventor： James A. Laugharn, JR.
CPC classification number: C12N13/00 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N1/286 , G01N2035/00554
Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。
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