专利检索 cpc:"C07D333/48" 第 3 页

21.

发明申请
New biphenyl and biphenyl-analogous compounds as integrin antagonists 失效
标题翻译：新的联苯和联苯类似物作为整联蛋白拮抗剂

公开(公告)号：US20040030132A1

公开(公告)日：2004-02-12

申请号：US10285073

申请日：2002-10-31

发明人： Markus Albers , Klaus Urbahns , Andrea Vaupel , Michael Harter , Delf Schmidt , Beatrix Stelte-Ludwig , Christoph Gerdes , Elke Stahl , Jorg Keldenich , Ulf Brueggemeier , Klemens Lustig

IPC分类号： C07D417/02 , C07D413/02

CPC分类号： C07D213/40 , C07C237/36 , C07C271/22 , C07C275/42 , C07C311/06 , C07C311/09 , C07C311/10 , C07C311/11 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/43 , C07C311/47 , C07C317/14 , C07C323/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/34 , C07D213/38 , C07D213/55 , C07D213/74 , C07D213/75 , C07D213/82 , C07D231/18 , C07D233/64 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/30 , C07D235/32 , C07D261/10 , C07D263/58 , C07D277/42 , C07D277/54 , C07D277/82 , C07D285/10 , C07D285/135 , C07D285/14 , C07D295/096 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/52 , C07D333/34 , C07D333/48 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12

摘要： The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) 1 wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.

摘要翻译： 本发明涉及联苯和联苯类似物，其作为药物组合物的制备和用途，作为整联蛋白拮抗剂，特别涉及用于治疗和预防癌症，动脉硬化，再狭窄，溶骨性疾病如骨质疏松和眼科疾病根据本发明的化合物具有式（1）其中R 1，R 2，U，V，A，B，W，R 3，C和R 4具有如索赔。

22.

发明申请
Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效

公开(公告)号：US20030191319A1

公开(公告)日：2003-10-09

申请号：US10157019

申请日：2002-05-30

申请人： G.D. Searle & Co.

发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz

IPC分类号： C07D213/24 , C07D207/46 , C07C311/47

CPC分类号： C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D263/34 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D405/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139

摘要： null- and null-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

23.

发明申请
Compounds which inhibit leukocyte adhesion mediated by VLA-4 失效

公开(公告)号：US20030144328A1

公开(公告)日：2003-07-31

申请号：US10218445

申请日：2002-08-15

发明人： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Dimitrios Sarantakis , Gregory S. Welmaker , Anthony Kreft , Christopher Semko , Robert Warren Sulliva , Christopher Joseph Soares , Kiev Sui Ly , Christine M. Tarby

IPC分类号： A61K031/426 , A61K031/421 , A61K031/4168 , A61K031/235 , A61K031/19

CPC分类号： A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00

摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

24.

发明申请
Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 失效

公开(公告)号：US20030125324A1

公开(公告)日：2003-07-03

申请号：US10218366

申请日：2002-08-15

发明人： Andrei W. Konradi , Michael A. Pleiss , Eugene D. Thorsett , Susan Ashwell , Gregory S. Welmaker , Anthony Kreft , Dimitrios Sarantakis , Darren B. Dressen , Francine S. Grant , Christopher Semko , Ying-Zi Xu

IPC分类号： A61K031/535 , A61K031/54 , A61K031/445 , A61K031/496 , A61K031/427 , A61K031/425

CPC分类号： A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00

摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

25.

发明授权
&agr;, &bgr;-unsaturated sulfones for treating proliferative disorders 有权
标题翻译： α，β-不饱和砜用于治疗增殖性疾病

公开(公告)号：US06541475B2

公开(公告)日：2003-04-01

申请号：US09833834

申请日：2001-04-12

申请人： E. Premkumar Reddy , M. V. Ramana Reddy

发明人： E. Premkumar Reddy , M. V. Ramana Reddy

IPC分类号： A61K31495

CPC分类号： C07D207/333 , C07C317/10 , C07D213/34 , C07D277/36 , C07D307/10 , C07D333/18 , C07D333/42 , C07D333/48

摘要： &agr;, &bgr;-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents:

摘要翻译： 提供下式的α，β-不饱和砜，其可用作抗增殖剂，包括例如抗癌剂：

26.

发明申请
Nitrate esters and methods of making same 有权
标题翻译：硝酸酯及其制备方法

公开(公告)号：US20020147234A1

公开(公告)日：2002-10-10

申请号：US10108513

申请日：2002-03-29

发明人： Gregory R.J. Thatcher , Brian M. Bennett , James N. Reynolds , Roland J. Boegman , Khem Jhamandas

IPC分类号： A61K031/21

CPC分类号： C07D307/33 , A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/341 , A61K31/381 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/575 , A61K31/662 , A61K31/7068 , C07C203/04 , C07C255/14 , C07C317/18 , C07C323/12 , C07C327/28 , C07C331/10 , C07C381/02 , C07D277/24 , C07D327/04 , C07D333/48 , C07D339/08 , C07D411/04 , C07F9/091 , C07F9/4006 , C07J41/0061

摘要： Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 描述了用于减轻神经变性，影响神经保护和/或影响受试者的认知增强的化合物和方法。通过向受试者施用有效量的包含硝酸酯或其药学上可接受的盐或酯的治疗化合物来治疗神经或认知状况。

27.

发明授权
Nitrate esters and their use for neurological conditions 有权
标题翻译：硝酸酯及其用于神经病学条件

公开(公告)号：US06365579B2

公开(公告)日：2002-04-02

申请号：US09851591

申请日：2001-05-10

申请人： Gregory R. J. Thatcher , Brian M. Bennett , James N. Reynolds , Roland J. Boegman , Khem Jhamandas

发明人： Gregory R. J. Thatcher , Brian M. Bennett , James N. Reynolds , Roland J. Boegman , Khem Jhamandas

IPC分类号： A61K31255

CPC分类号： C07D307/33 , A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/341 , A61K31/381 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/575 , A61K31/662 , A61K31/7068 , C07C203/04 , C07C255/14 , C07C317/18 , C07C323/12 , C07C327/28 , C07C331/10 , C07C381/02 , C07D277/24 , C07D327/04 , C07D333/48 , C07D339/08 , C07D411/04 , C07F9/091 , C07F9/4006 , C07J41/0061

摘要： Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 描述了用于减轻神经变性，影响神经保护和/或影响受试者的认知增强的化合物和方法。通过向受试者施用有效量的包含硝酸酯或其药学上可接受的盐或酯的治疗化合物来治疗神经或认知状况。