公开(公告)号：US11806447B2

公开(公告)日：2023-11-07

申请号：US16254085

申请日：2019-01-22

申请人： Tepha, Inc.

发明人： David P. Martin ,  Simon F. Williams ,  Kai Guo

IPC分类号： A61L31/06 ,  A61L31/10 ,  C12P7/625 ,  G01N33/50 ,  A61L27/18 ,  C08G63/06 ,  A61L27/34 ,  A61L17/10 ,  C08G63/90

CPC分类号： A61L31/06 ,  A61L17/105 ,  A61L27/18 ,  A61L27/34 ,  A61L31/10 ,  C08G63/06 ,  C08G63/90 ,  C12P7/625 ,  G01N33/5088 ,  Y10T436/201666 ,  A61L17/105 ,  C08L67/04 ,  A61L27/18 ,  C08L67/04 ,  A61L27/34 ,  C08L67/04 ,  A61L31/06 ,  C08L67/04 ,  A61L31/10 ,  C08L67/04

摘要： Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.

公开(公告)号：US20230293421A1

公开(公告)日：2023-09-21

申请号：US17794708

申请日：2021-06-23

申请人： L'OREAL

发明人： Etienne SAVONNET ,  Romain GARCON ,  Julien PORTAL

IPC分类号： A61K8/85 ,  A61Q1/06 ,  A61K8/19 ,  A61K8/31 ,  C12P7/625 ,  C12N1/20

CPC分类号： A61K8/85 ,  A61K8/19 ,  A61K8/31 ,  A61Q1/06 ,  C12N1/205 ,  C12P7/625 ,  A61K2800/43 ,  A61K2800/85 ,  C12R2001/38

摘要： The invention relates to a composition comprising: a) one or more polyhydroxyalkanoate (PHA) copolymers which contain, and preferably consist of, at least two different repeating polymer units chosen from the units (A) and (B) below, and also the optical or geometrical isomers thereof and the solvates thereof such as hydrates: -[-0-CH(R1)-CH2-C(0)-]- unit (A) -[-0-CH(R2)-CH2-C(0)-]- unit (B) in which polymer units (A) and (B): R1 represents a hydrocarbon-based chain chosen from: i) branched (C5-C9)alkyl, ii) (C10-C30)alkyl; iii) linear or branched (C5-C30)alkenyl; iv) linear or branched (C5-C30)alkynyl; v) (hetero)aryl; vi) (hetero)cycloalkyl; preferably the group i) (C10-C20)alkyl, or iii) (C8-C20)alkenyl; R2 represents a cyclic or non-cyclic, linear or branched, saturated or unsaturated hydrocarbon-based group, comprising from 1 to 30 carbon atoms; and b) a fatty medium comprising one or more fatty substances; preferably, the fatty substance(s) are liquid at 25°C and at atmospheric pressure; it being understood that (A) is different from (B).

公开(公告)号：US20230265468A1

公开(公告)日：2023-08-24

申请号：US18133912

申请日：2023-04-12

申请人： KANEKA CORPORATION

发明人： Ken Harada ,  Shunsuke Sato

IPC分类号： C12P7/625

CPC分类号： C12P7/625

摘要： In culturing a poly(3-hydroxyalkanoate)-producing microorganism, an oil A and an oil B are used as the carbon source. The proportion of the oil B to the total amount of the oils A and B used during the entire course of the culturing is 10 wt% or more. The oil A is the total oil used until the amount of the poly(3-hydroxyalkanoate) accumulated in the poly(3-hydroxyalkanoate)-producing microorganism reaches 16 wt%, and the average unsaturated fatty acid content in constituent fatty acids is from 25 wt% to less than 75 wt% in the total oil A. The unsaturated fatty acid content in constituent fatty acids in the oil B is higher than the average unsaturated fatty acid content in the total oil A.

公开(公告)号：US11702680B2

公开(公告)日：2023-07-18

申请号：US16399155

申请日：2019-04-30

申请人： INV Nylon Chemicals Americas, LLC

发明人： Alexander Brett Foster ,  Cristina Serrano Amatriain ,  Gary J. Smith ,  Paul Sheldon Pearlman ,  Mark Paul Taylor

IPC分类号： C12P7/625 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P7/04 ,  C12P7/06 ,  C12P7/42

CPC分类号： C12P7/625 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/13 ,  C12N9/88 ,  C12P7/04 ,  C12P7/065 ,  C12P7/42 ,  C12Y101/01001 ,  C12Y203/01016 ,  C12Y208/03015 ,  C12Y401/01004 ,  C12N2500/02 ,  C12N2500/05 ,  C12N2500/12 ,  C12N2500/24

摘要： Provided herein are methods for generating cellular biomass in continuous aerobic fermentation systems. The biomass yield, and the concentration of polyhydroxyalkanoate within the biomass, are each directed to advantageous levels by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are biomass produced using the provided methods, and animal feed compositions including the provided biomass.

公开(公告)号：US20230116483A1

公开(公告)日：2023-04-13

申请号：US17907278

申请日：2021-03-25

申请人： SUMITOMO FORESTRY CO., LTD.

发明人： Kotaro INO ,  Kenichi KADOTA

IPC分类号： C12P7/625 ,  C12N1/20

摘要： A method for producing a polyhydroxyalkanoate that includes the following steps: (a) a step for culturing halobacteria with a culture medium containing sea water; and (b) a step for obtaining a polyhydroxyalkanoate as product of the culture.

公开(公告)号：US20220372528A1

公开(公告)日：2022-11-24

申请号：US17605389

申请日：2020-04-25

申请人： ZYMOCHEM, INC.

发明人： Harshal Chokhawala ,  Jonathan Kuchenreuther ,  Jorge-Alonso Gutierrez ,  Yi-Shu Tai

IPC分类号： C12P7/625 ,  C12P7/40 ,  C12P7/62 ,  C12N15/52 ,  C12N15/70 ,  C12N1/20

摘要： Among other things, the present disclosure provides biosynthesis polypeptides, methods, and non-naturally occurring microbial organisms for preparing various compounds such as 1,5-pentanediol, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, and 2-keto carboxylic acids.

公开(公告)号：US20220145338A1

公开(公告)日：2022-05-12

申请号：US17582744

申请日：2022-01-24

申请人： Oxford University Innovation Limited ,  U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

发明人： Richard Lewis Veech ,  Michael Todd King ,  Kieran Clarke

IPC分类号： C12P7/625 ,  C07H13/04 ,  C12P7/26 ,  C07C51/09 ,  C08G63/06 ,  C12P7/62 ,  C07C69/675

摘要： Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.

公开(公告)号：US11306333B2

公开(公告)日：2022-04-19

申请号：US16152354

申请日：2018-10-04

申请人： LanzaTech, Inc.

发明人： Ryan Christopher Tappel ,  James Bruce Yarnton Haycock Behrendorff ,  Michael Koepke ,  Esteban Marcellin ,  Renato de Souza Pinto Lemgruber ,  Kaspar Valgepea ,  Lars Nielsen

IPC分类号： C12P7/62 ,  C12N9/10 ,  C12N9/04 ,  C12P7/625

摘要： The invention provides microorganisms and methods for the production of polyhydroxybutyrate (PHB) from gaseous substrates. In particular, the invention provides a non-naturally occurring Wood-Ljungdahl microorganism comprising (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and (c) an enzyme that converts 3-hydroxybutyryl-CoA to polyhydroxybutyrate, and methods related thereto.

公开(公告)号：US11268113B2

公开(公告)日：2022-03-08

申请号：US16616276

申请日：2018-05-23

申请人： KANEKA CORPORATION

发明人： Rina Aoki ,  Shunsuke Sato

IPC分类号： C12N1/20 ,  C12P7/62 ,  C12N9/10 ,  C12N15/74 ,  C12P7/625

摘要： Provided are a PHA-producing microorganism producing a higher molecular weight PHA and a PHA production method using the PHA-producing microorganism. A PHA-producing microorganism including a gene encoding a PHA synthase derived from genus Aeromonas, in which at least a portion of a PHA degrading enzyme gene is altered by substitution, deletion, insertion, and/or addition to reduce or eliminate activity of a PHA degrading enzyme encoded by the gene, and further a glycerol kinase activity is enhanced.

公开(公告)号：US20240309417A1

公开(公告)日：2024-09-19

申请号：US18413954

申请日：2024-01-16

申请人： Ramon Gonzalez

发明人： Ramon Gonzalez ,  James Clomburg ,  Alexander Chou

IPC分类号： C12P19/32 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P5/02 ,  C12P7/02 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/625 ,  C12P9/00 ,  C12P13/00 ,  C12P13/04

CPC分类号： C12P19/32 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0077 ,  C12N9/13 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P5/02 ,  C12P5/026 ,  C12P7/02 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/625 ,  C12P9/00 ,  C12P13/001 ,  C12P13/04 ,  C12Y101/01 ,  C12Y101/03039 ,  C12Y102/01 ,  C12Y102/04001 ,  C12Y103/05001 ,  C12Y103/99 ,  C12Y108/01004 ,  C12Y114/15003 ,  C12Y203/01012 ,  C12Y203/01054 ,  C12Y207/01031 ,  C12Y208/03 ,  C12Y401/00 ,  C12Y401/01 ,  C12Y401/01047 ,  C12Y401/03024 ,  C12Y402/01 ,  C12Y402/01002 ,  C12Y402/01011 ,  C12Y501/99001 ,  C12Y501/99002 ,  C12Y504/02 ,  C12Y504/99 ,  C12Y504/99001 ,  C12Y504/99002 ,  C12Y602/01 ,  C12Y602/01005 ,  C12Y604/01003 ,  Y02E50/30

摘要： An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.