Abstract:
Disclosed is a novel long-acting glucagon conjugate in which glucagon or its derivative is covalently linked to a polymer carrier via a non-peptide linker, and a pharmaceutical composition comprising the same as an effective ingredient useful for the prevention and treatment of obesity. Since the long-acting glucagon conjugate of the present invention shows improved in vivo durability and stability, when used in combination with an anti-obesity drug, it is possible to induce synergistic effects on the loss of body weight and decrease in food intake without causing any side-effects such as fluctuation in blood glucose level. Accordingly, the long-acting peptide conjugate of the present invention is very effective for the prevention and treatment of obesity.
Abstract:
Provided is a stacked semiconductor package. The stacked semiconductor package of the present invention comprises: a substrate including at least one contact pad; an external chip laminate which includes a plurality of semiconductor chips mounted on the substrate, and which is stacked in multi-steps such that the ends at one side of the plurality of semiconductor chips alternately protrude in opposite directions to expose bonding pads which are formed on the up-face surface; at least one internal chip which is disposed in a mounting space formed between the external chip laminate and substrate so as to be electrically connected to the substrate; and a conductive wire electrically connecting the bonding pad of the semiconductor chip and the contact pad of the substrate.
Abstract:
Provided is a stacked semiconductor package. The stacked semiconductor package of the present invention comprises: a substrate including at least one contact pad; an external chip laminate which includes a plurality of semiconductor chips mounted on the substrate, and which is stacked in multi-steps such that the ends at one side of the plurality of semiconductor chips alternately protrude in opposite directions to expose bonding pads which are formed on the up-face surface; at least one internal chip which is disposed in a mounting space formed between the external chip laminate and substrate so as to be electrically connected to the substrate; and a conductive wire electrically connecting the bonding pad of the semiconductor chip and the contact pad of the substrate.
Abstract:
A supporter usable with a display apparatus includes a base, a vertical moving member coupled to a display main body, a guide frame coupled to the base to support the vertical moving member to slide up and down, a spring rotor supported in the vertical moving member rotatably having a rotational axis transverse to a moving direction of the vertical moving member to move up and down along with the vertical moving member, a spiral plate spring having an inside end part coupled to the spring rotor as being wound around the spring rotor and an outside end part coupled to the guide frame to elastically resist a downward movement of the vertical moving member, a spring friction part to frictionally contact the spiral plate spring to resist a rotational movement of the spiral plate spring, and a rotor friction part to frictionally contact the spring rotor to resist a rotational movement of the spring rotor.
Abstract:
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Abstract:
A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
Abstract:
The present invention relates to a Vestigial Side Band (VSB) Digital Television (DTV) in agreement with the DTV standards (A/53) of the Advanced Television System Committee (ATSC), and to a method thereof. More particularly, it provides 4-VSB DTV transceiver that improves reception performance of a receiver by transmitting and receiving dual streams formed of normal data and robust data without increasing average power, regardless of a mixing ratio of the normal and robust data. The 4-VSB DTV transceiver of the present research includes an encoding unit for encoding the robust data to be mapped to one of two groups having 4 levels {−5, −3, 1, 7} and {−7, −1, 3, 5}.
Abstract:
Disclosed are acrylic polymer beads and an acrylic sol composition containing the acrylic polymer beads that are used for automobile underbody floor, wheel housing, fuel tank, body panel junction and hood, door, or the like for the purpose of water tightness, vibration isolation, and anticorrosion. More specifically, the acrylic polymer beads having a core/shell structure, which are prepared by using a part of the monomer constituting a core layer to form seeds by a seed polymerization, polymerizing the rest of the monomer to form a core layer and then foaming a shell layer containing an appropriate amount of a crosslink agent, have a narrow particle size distribution and thereby provide, when used in addition to a plasticizer and a filler in the preparation of an acrylic sol composition for automobile, high storage stability of the acrylic sol and excellent properties of the coating formed by gelation of the acrylic sol.
Abstract:
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
Abstract:
A display apparatus includes a front casing and a rear casing, a CRT coupled to the front casing and mounted with a degaussing coil, and a main board disposed adjacent to the CRT to transmit electrical signals to the CRT. A base frame receives therein the main board. A frame supporting part, which is positioned in a rear part of the front casing, supports the base frame so as to have an upward angle of inclination in a backward direction. With this configuration, a display apparatus has a visual volume that is reduced to a minimum and the assembly is prevented from tipping forward in the assembling processes.