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    ADVANCED PULMONARY MODELS
    34.
    发明公开
    ADVANCED PULMONARY MODELS 审中-公开

    公开(公告)号：US20230287355A1

    公开(公告)日：2023-09-14

    申请号：US18083916

    申请日：2022-12-19

    Applicant: EMULATE, INC.

    Inventor： Remi Villenave ,  Carolina Lucchesi ,  Justin Nguyen ,  Catherine Karalis ,  Geraldine Hamilton ,  Buket Baddal ,  Michael Salmon

    IPC: C12N5/071 ,  B01L3/00 ,  C12N1/20

    CPC classification number: C12N5/0688 ,  B01L3/502769 ,  C12N1/20 ,  C12N2502/00

    Abstract: The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.

    ANTIBODY PRODUCING MICROFLUIDIC DEVICES
    37.
    发明申请
    ANTIBODY PRODUCING MICROFLUIDIC DEVICES 有权

    公开(公告)号：US20220282211A1

    公开(公告)日：2022-09-08

    申请号：US17746097

    申请日：2022-05-17

    Applicant: EMULATE, INC.

    Inventor： Alicia Stark ,  Brar Gurpreet

    IPC: C12N5/0781 ,  C12M3/06 ,  C07K16/00

    Abstract: The present invention relates to fluidic systems for producing IgG antibodies from co-cultures of white blood cells. In some embodiments, a microfluidic device containing co-cultures of an autologous whole peripheral white blood cell population including B cells, are used for providing antigen specific IgG antibody production from differentiating B cells (plasma cells). More specifically, high levels of IgM and IgG classes of antibodies are harvested from fluids flowing through the device. In some embodiments, IgG is produced during activation in the presence of antigen, including but not limited to therapeutic immunogenic compounds, e.g. engineered antibodies, vaccines, etc. In some embodiments, such co-cultures are further exposed to drug compounds e.g. for preclinical safety testing and individualized personal drug responses. In some embodiments, such antibody producing microfluidic devices are contemplated for use in companion diagnostic and complementary assays.

    IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS
    40.
    发明申请
    IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS 有权

    公开(公告)号：US20220081663A1

    公开(公告)日：2022-03-17

    申请号：US17527422

    申请日：2021-11-16

    Applicant: EMULATE, INC.

    Inventor： S. Jordan Kerns ,  Jenifer Obrigewitch ,  Micheal Salmon ,  Benjamin Richards Umiker

    IPC: C12M3/06 ,  G01N33/50 ,  B01L3/00 ,  C12N5/077 ,  C12N5/071 ,  C07K16/28 ,  C12M1/12 ,  C12N5/0783

    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.

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