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公开(公告)号：US20170234833A1
公开(公告)日：2017-08-17
申请号：US15583501
申请日：2017-05-01
Applicant: International Business Machines Corporation
Inventor： Binquan Luan , Gustavo A. Stolovitzky , Chao Wang , Deqiang Wang
IPC: G01N27/447 , C12Q1/68 , G01N33/487
CPC classification number: G01N27/44791 , B82Y30/00 , C12Q1/6869 , G01N27/403 , G01N33/48721
Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.
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公开(公告)号：US20170212098A1
公开(公告)日：2017-07-27
申请号：US15005576
申请日：2016-01-25
Applicant: International Business Machines Corporation
Inventor： Gustavo A. Stolovitzky , Chao Wang
IPC: G01N33/487 , B01L3/00
CPC classification number: G01N33/48721 , B01L3/502715 , B01L3/502761 , B01L2200/0663 , B01L2300/0816 , B01L2300/0896 , B01L2400/086
Abstract: A technique relates to stretching an extensible molecule. The molecule moves through an array of pillars in a flow direction, where the array has an interface connecting a first pillar region and a second pillar region. Stretching the molecule by traversing the molecule in the flow direction through the interface connecting the first pillar region to the second pillar region, such that a first end and a second end of the molecule straddle a straddle pillar, thereby causing the first end to extend along a first path in the second and the second end to extend along a second path. Traversing the molecule stretches the first end and the second end along two different paths. The molecule is further traversed through the array such that the second end follows the first end along the first path, where the stretching causes the molecule to be in an uncoiled state.
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公开(公告)号：US20170144149A1
公开(公告)日：2017-05-25
申请号：US14947745
申请日：2015-11-20
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Cornelia K. Tsang , Chao Wang , Benjamin H. Wunsch
CPC classification number: B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2200/12 , B01L2300/0887 , B01L2300/0896 , B01L2300/12 , B01L2400/086 , B81B7/0061 , B81B2201/058 , B81B2203/0338 , B81C1/00309 , B81C2203/0118 , G01N15/0255 , G01N15/10 , G01N2015/0288 , G01N2015/1081
Abstract: Techniques for use of wafer bonding techniques for sealing of microfluidic chips are provided. In one aspect, a wafer bonding sealing method includes the steps of: forming a first oxide layer coating surfaces of a first wafer, the first wafer having at least one fluidic chip; forming a second oxide layer on a second wafer; and bonding the first wafer to the second wafer via an oxide-to-oxide bond between the first oxide layer and the second oxide layer to form a bonded wafer pair, wherein the second oxide layer seals the at least one fluidic chip on the first wafer. The second wafer can be at least partially removed after performing the bonding, and fluidic ports may be formed in the second oxide layer. A fluidic chip device is also provided.
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34.发明申请公开(公告)号：US20160199833A1
公开(公告)日：2016-07-14
申请号：US15074701
申请日：2016-03-18
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Qinghuang Lin , Gustavo A. Stolovitzky , Chao Wang , Deqiang Wang
IPC: B01L3/00
CPC classification number: G01N33/48721 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0663 , B01L2200/12 , B01L2300/042 , B01L2300/0645 , B01L2300/0887 , B01L2300/0896 , B01L2300/161 , B01L2400/0415 , B01L2400/0421 , G01N27/447 , G01N27/44791 , Y10T29/49002
Abstract: A device for passing a biopolymer molecule includes a nanochannel formed between a surface relief structure, a patterned layer forming sidewalls of the nanochannel and a sealing layer formed over the patterned layer to encapsulate the nanochannel. The surface relief structure includes a three-dimensionally rounded surface that reduces a channel dimension of the nanochannel at a portion of nanochannel and gradually increases the dimension along the nanochannel toward an opening position, which is configured to receive a biopolymer.
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公开(公告)号：US20160146718A1
公开(公告)日：2016-05-26
申请号：US14749202
申请日：2015-06-24
Applicant: International Business Machines Corporation
Inventor： Yann A. Astier , Joshua T. Smith , Gustavo A. Stolovitzky , Chao Wang , Benjamin H. Wunsch
IPC: G01N15/10
CPC classification number: G01N15/1031 , B01L3/502707 , B01L3/502761 , B01L2200/0652 , B01L2300/0864 , B01L2300/161 , G01N15/02 , G01N27/3278 , G01N33/48721 , G01N2015/0038 , G01N2015/0288
Abstract: A technique relates sorting biopolymers. The biopolymers are introduced into a nanopillar array, and the biopolymers include a first population and a second population. The nanopillar array includes nanopillars arranged to have a gap separating one from another. The biopolymers are sorted through the nanopillar array by transporting the first population of the biopolymers less than a predetermined bumping size according to a fluid flow direction and by transporting the second population of the biopolymers at least the predetermined bumping size according to a bumped direction different from the fluid flow direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the biopolymers.
Abstract translation: 一种技术涉及排序生物聚合物。 将生物聚合物引入纳米柱阵列中，并且生物聚合物包括第一群体和第二群体。 纳米柱阵列包括布置成具有彼此分离的间隙的纳米柱。 生物聚合物通过纳米柱阵列分选，根据流体流动方向传送生物聚合物的第一群体小于预定的碰撞尺寸，并且根据不同于第一群体的碰撞方向，将生物聚合物的第二群体输送至少至少预定的碰撞大小 流体流动方向。 纳米柱阵列被配置为采用具有小于300纳米的间隙尺寸的间隙，以分类生物聚合物。
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Patent Agency Ranking
36.发明授权公开(公告)号：US08906215B2
公开(公告)日：2014-12-09
申请号：US13690149
申请日：2012-11-30
Applicant: International Business Machines Corporation
Inventor： Ajay K. Royyuru , Chao Wang
IPC: G01N27/447 , G01N33/68 , B82Y15/00 , G01N27/414 , B82Y30/00
CPC classification number: G01N27/44791 , B82Y15/00 , B82Y30/00 , G01N27/414 , G01N27/447 , G01N33/48721 , G01N33/68 , Y10S977/733 , Y10S977/832 , Y10S977/853 , Y10S977/962
Abstract: A mechanism is provided for manipulating a molecule. The molecule is driven into a nanochannel filed with electrically conductive fluid. A first vertical electric field is created inside the nanochannel to slow down the molecule and/or immobilize the molecule. The molecule is stretched into non-folded linear chains by the first vertical electric field and a horizontal electric field. Monomers of the molecule are sequentially read.
Abstract translation: 提供了用于操纵分子的机制。 该分子被驱动到具有导电流体的纳米通道中。 在纳米通道内形成第一垂直电场，以减缓分子和/或固定分子。 通过第一垂直电场和水平电场将分子拉伸成非折叠线性链。 顺序读取分子的单体。
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公开(公告)号：US20140302675A1
公开(公告)日：2014-10-09
申请号：US13856471
申请日：2013-04-04
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Yann Astier , Jingwei Bai , Michael F. Lofaro , Satyavolu S. Papa Rao , Joshua T. Smith , Chao Wang
IPC: H01L21/306
CPC classification number: H01L21/30625 , B81B2201/0214 , B81C1/00087 , G01N33/48721
Abstract: A nanogap of controlled width in-between noble metals is produced using sidewall techniques and chemical-mechanical-polishing. Electrical connections are provided to enable current measurements across the nanogap for analytical purposes. The nanogap in-between noble metals may also be formed inside a Damascene trench. The nanogap in-between noble metals may also be inserted into a crossed slit nanopore framework. A noble metal layer on the side of the nanogap may have sub-layers serving the purpose of multiple simultaneous electrical measurements.
Abstract translation: 使用侧壁技术和化学机械抛光产生在贵金属之间的受控宽度的纳米隙。 提供电连接以实现跨越纳米隙的电流测量用于分析目的。 贵金属之间的纳米隙也可以形成在镶嵌槽内。 贵金属之间的纳米隙也可以插入交叉的狭缝纳米孔框架中。 在纳米隙侧面上的贵金属层可以具有用于多次同时电测量的子层。
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公开(公告)号：US10094805B2
公开(公告)日：2018-10-09
申请号：US15583501
申请日：2017-05-01
Applicant: International Business Machines Corporation
Inventor： Binquan Luan , Gustavo A. Stolovitzky , Chao Wang , Deqiang Wang
IPC: G01N1/10 , G01N27/447 , G01N33/487 , C12Q1/6869
Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.
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39.发明授权公开(公告)号：US10058895B2
公开(公告)日：2018-08-28
申请号：US14697072
申请日：2015-04-27
Applicant: International Business Machines Corporation
Inventor： Yann A. Astier , Joshua T. Smith , Gustavo A. Stolovitzky , Chao Wang , Benjamin H. Wunsch
CPC classification number: B07B13/04 , B07B1/4609 , B82Y30/00 , G01N15/02 , G01N30/6095 , G01N2015/0065 , G01N2015/0288 , Y10S977/84
Abstract: A technique relates sorting entities. The entities are introduced into a nanopillar array. The entities include a first population and a second population, and the nanopillar array includes nanopillars arranged to have a gap separating one from another. The nanopillars are ordered to have an array angle relative to a fluid flow direction. The entities are sorted through the nanopillar array by transporting the first population of the entities less than a predetermined size in a first direction and by transporting the second population of the entities at least the predetermined size in a second direction different from the first direction. The nanopillar array is configured to employ the gap with a gap size less than 300 nanometers in order to sort the entities having a sub-100 nanometer size.
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公开(公告)号：US20180021774A1
公开(公告)日：2018-01-25
申请号：US15722796
申请日：2017-10-02
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Cornelia K. Tsang , Chao Wang , Benjamin H. Wunsch
CPC classification number: B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2200/0689 , B01L2200/12 , B01L2300/0887 , B01L2300/0896 , B01L2300/12 , B01L2400/086 , B81B7/0061 , B81B2201/058 , B81B2203/0338 , B81C1/00309 , B81C2203/0118 , G01N15/0255 , G01N15/10 , G01N2015/0288 , G01N2015/1081
Abstract: Techniques for use of wafer bonding techniques for sealing of microfluidic chips are provided. In one aspect, a wafer bonding sealing method includes the steps of: forming a first oxide layer coating surfaces of a first wafer, the first wafer having at least one fluidic chip; forming a second oxide layer on a second wafer; and bonding the first wafer to the second wafer via an oxide-to-oxide bond between the first oxide layer and the second oxide layer to form a bonded wafer pair, wherein the second oxide layer seals the at least one fluidic chip on the first wafer. The second wafer can be at least partially removed after performing the bonding, and fluidic ports may be formed in the second oxide layer. A fluidic chip device is also provided.
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