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55 条记录 (耗时 0.051 秒)

    Advanced analyte sensor calibration and error detection
    33.
    发明授权
    Advanced analyte sensor calibration and error detection 有权
    先进的分析物传感器校准和错误检测

    公开(公告)号：US09149220B2

    公开(公告)日：2015-10-06

    申请号：US13446977

    申请日：2012-04-13

    申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

    发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

    IPC分类号： G08B21/00 ,  A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

    CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

    摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

    摘要翻译： 提供了用于处理传感器数据和自校准的系统和方法。 在一些实施例中，提供了能够基于初始灵敏度来校准连续分析物传感器，然后在不使用或减少使用参考测量的情况下连续执行自校准的系统和方法。 在某些实施例中，通过应用作为某些参数的函数的估计算法来确定分析物传感器的灵敏度。 本文还描述了使用刺激信号来确定分析物传感器的性质的系统和方法。 传感器属性可用于补偿传感器数据的灵敏度漂移，或确定与传感器相关的其他属性，如温度，传感器膜损坏，传感器电子设备中的水分进入以及缩放因子。

    Malfunction detection with derivative calculation
    34.
    发明授权
    Malfunction detection with derivative calculation 有权
    导数计算的故障检测

    公开(公告)号：US07944366B2

    公开(公告)日：2011-05-17

    申请号：US11532691

    申请日：2006-09-18

    申请人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

    发明人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

    IPC分类号： G08B21/00 ,  A61M31/00 ,  A61M37/00 ,  A61M1/00 ,  G01F25/00 ,  B23H11/00 ,  G01R31/00

    CPC分类号： A61M5/14244 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/16831 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2205/3317 ,  A61M2205/3389

    摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

    摘要翻译： 讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。 例如，电动输液泵可能在流体流动路径中产生闭塞，这可能破坏从泵分散的流体的控制。 同样，输液器断开也可能导致流体损失，这可能是破坏性的。 对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。 因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。 例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。 还描述了用于利用位置传感器的其它算法。

    TRANSCUTANEOUS ANALYTE SENSOR
    35.
    发明申请
    TRANSCUTANEOUS ANALYTE SENSOR 有权
    TRANSCUTANEOUS分析仪传感器

    公开(公告)号：US20110077490A1

    公开(公告)日：2011-03-31

    申请号：US12893850

    申请日：2010-09-29

    申请人： Peter C. Simpson ,  Robert Boock ,  Sebastian Bohm ,  James H. Brauker ,  Paul V. Neale

    发明人： Peter C. Simpson ,  Robert Boock ,  Sebastian Bohm ,  James H. Brauker ,  Paul V. Neale

    IPC分类号： A61B5/1473

    CPC分类号： A61B5/14865 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6843 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0443 ,  A61B2562/0209 ,  A61B2562/04

    摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

    摘要翻译： 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体能够在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种构造，其可以用于保护 传感器体的膜。

    Malfunction Detection Via Pressure Pulsation
    36.
    发明申请
    Malfunction Detection Via Pressure Pulsation 审中-公开
    通过压力脉动检测故障

    公开(公告)号：US20070093753A1

    公开(公告)日：2007-04-26

    申请号：US11532726

    申请日：2006-09-18

    申请人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

    发明人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

    IPC分类号： A61M37/00 ,  A61K9/22

    CPC分类号： A61M5/14244 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/16831 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2205/3317 ,  A61M2205/3389

    摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

    摘要翻译： 讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。 例如，电动输液泵可能在流体流动路径中产生阻塞，这可能破坏从泵分散的流体的控制。 同样，输液器断开也可能导致流体损失，这可能是破坏性的。 对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。 因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。 例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。 还描述了用于利用位置传感器的其它算法。

    Cap for a dermal tissue lancing device
    37.
    发明申请
    Cap for a dermal tissue lancing device 审中-公开
    用于皮肤组织穿刺装置的盖

    公开(公告)号：US20060184189A1

    公开(公告)日：2006-08-17

    申请号：US10706166

    申请日：2003-11-12

    申请人： Lorin Olson ,  Anne Thomson ,  Damian Baskeyfield ,  Christopher Leach ,  Richard Day ,  Sebastian Bohm

    发明人： Lorin Olson ,  Anne Thomson ,  Damian Baskeyfield ,  Christopher Leach ,  Richard Day ,  Sebastian Bohm

    IPC分类号： A61B17/32

    CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150183 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15186

    摘要： A cap for use with a dermal tissue lancing device (that includes a housing and a lancet movable with respect to the housing) includes a proximal end for engaging with the housing, a distal end for engaging with dermal tissue and an opening for a portion of the lancet to pass through. The distal end of the cap includes portions for engaging dermal tissue. These portions are resiliently deformable such that, when the cap contacts and is urged towards dermal tissue, the portions deform resiliently, engaging the dermal tissue and approaching theretogether. A process for the collection of a fluid sample (e.g., blood) from dermal tissue includes providing a dermal tissue lancing device with a housing, a cap and a lancet that is moveable with respect to the housing and the cap. The cap includes a proximal end for engaging with the housing, a distal end for engaging with dermal tissue, and an opening for a portion of the lancet to pass through. The distal end of the cap includes resiliently deformable portions for engaging dermal tissue. Next, the cap is contacted with the dermal tissue (e.g., dermal tissue of a fingertip, limb, or abdomen) such that the portions engage the dermal tissue. Subsequently, the cap is urged towards the dermal tissue such that at least first and second portions deform resiliently and approach theretogether to create a bulge in the dermal tissue. The bulge is then lanced to create a puncture from which a fluid sample is collected.

    摘要翻译： 用于真皮组织穿刺装置（包括壳体和相对于壳体可移动的刺血针）的帽包括用于与壳体接合的近端，用于与真皮组织接合的远端和用于部分 刺血针通过。 帽的远端包括用于接合皮肤组织的部分。 这些部分是可弹性变形的，使得当帽接触并被推向真皮组织时，这些部分弹性变形，与真皮组织接合并且一起接近。 用于从真皮组织收集流体样品（例如血液）的方法包括提供真皮组织切割装置，其具有可相对于壳体和盖移动的壳体，帽和刺血针。 盖包括用于与壳体接合的近端，用于与真皮组织接合的远端和用于刺血针的一部分通过的开口。 盖的远端包括用于接合皮肤组织的弹性变形部分。 接下来，将盖与真皮组织（例如，指尖，肢体或腹部的真皮组织）接触，使得这些部分接合皮肤组织。 随后，将帽推向真皮组织，使得至少第一和第二部分弹性变形并且一起接近以在真皮组织中产生凸起。 然后将凸起切开以产生从中收集流体样品的穿刺。