公开(公告)号：US20160266077A1

公开(公告)日：2016-09-15

申请号：US15062430

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Abhijit Tarafder ,  Joseph D. Michienzi ,  Joshua A. Shreve

IPC: G01N30/30

CPC classification number: G01N30/30 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053

Abstract: Analytical-scale separation column assemblies include a tube with a bore packed with a stationary phase through which a mobile phase flows. In one embodiment, thermal elements are disposed remotely from and unattached to the tube. The thermal elements are in thermal communication with an external surface of the tube for producing a spatial thermal gradient outside of and along a length of the tube. In another embodiment, discrete, spatially separated strips of thermally conductive material are disposed on and wrapped around an external surface of the tube. Thermal elements are disposed remotely from the tube. Each thermal element is in thermal communication with one strip of thermally conductive material by a heat-transfer device. The thermal elements produce a spatial thermal gradient outside of and along a tube length by controlling temperature of each strip of thermally conductive material disposed on and wrapped around the external surface of the tube.

Abstract translation: 分析级分离柱组件包括具有填充有流动相流过的固定相的孔的管。 在一个实施例中，热元件远离管并且不附接于管。 热元件与管的外表面热连通，用于在管的长度之外和沿着管的长度产生空间热梯度。 在另一个实施例中，离散的，空间上分离的导热材料条被布置在管的外表面上并且缠绕在管的外表面上。 热元件远离管放置。 每个热元件通过热传递装置与一条导热材料热连通。 热元件通过控制设置在管的外表面上并缠绕在管的外表面上的每个导热材料条的温度在管长度之外产生空间热梯度。

公开(公告)号：US20160266076A1

公开(公告)日：2016-09-15

申请号：US15062405

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: G01N30/30 ,  B01D15/16

CPC classification number: G01N30/30 ,  B01D15/16 ,  B01D15/161 ,  B01D15/40 ,  G01N30/02 ,  G01N30/54 ,  G01N2030/027 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  H01L33/645

Abstract: A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.

Abstract translation: 在分离塔内减少色谱带宽增长的系统和方法包括使流动相通过一段分离柱，并产生沿着分离柱外部和沿着分离柱长度的空间热梯度。 空间热梯度被特别配置为当流动相通过分离柱时抵消流动相的特性变化。 例如，抵消的特定变化可以是流动相的密度或温度的变化。 对于分析级列，例如，空间热梯度可以被配置为产生在分离柱的长度之外和沿着分离柱的长度，其基本上与流动相通过时沿柱长度预测形成的温度相匹配 分离柱，从而基本上防止在流动相中形成径向热梯度。

公开(公告)号：US20150330956A1

公开(公告)日：2015-11-19

申请号：US14713439

申请日：2015-05-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N31/12 ,  F23D14/28

CPC classification number: G01N30/68 ,  B01D15/40 ,  F23D14/00 ,  F23D2200/00 ,  F23D2206/00

Abstract: The present disclosure relates to burner assemblies of flame-based detectors. These burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.

Abstract translation: 本公开涉及基于火焰的检测器的燃烧器组件。 这些燃烧器组件被配置成将超临界流体色谱系统的减压流动相递送到基于火焰的检测器的火焰，同时提供分析物响应的改进优化以及在操作期间增强的火焰稳定性。

公开(公告)号：US20150290644A1

公开(公告)日：2015-10-15

申请号：US14747074

申请日：2015-06-23

Applicant: Waters Technologies Corporation

Inventor： David P. Prentice ,  Russell L. Keene ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Paul E. Linderson ,  Gary W. Bertone

IPC: B01L3/00

CPC classification number: B01D15/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0883 ,  B05B1/00 ,  B05B1/02 ,  G01N27/44791 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/724 ,  G01N30/7266 ,  H01J49/167 ,  Y10T137/598 ,  Y10T436/24

Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.

Abstract translation: 液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。 微流体衬底具有流体孔，通道将流体供应到通道。 墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。 夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。 端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。 第二壁具有狭槽，盒通过该槽进入腔室。 当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并且与微流体衬底中的一个流体孔隙建立流体连通。

公开(公告)号：US12007370B2

公开(公告)日：2024-06-11

申请号：US17347807

申请日：2021-06-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Fabrice Gritti

IPC: G01N30/30 ,  G01N30/02

CPC classification number: G01N30/30 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2030/3015 ,  G01N2030/3046

Abstract: Exemplary embodiments may compensate for expected frictional heating or Joule-Thomson cooling in chromatography columns. Frictional heating or Joule Thomson cooling are the same thing for a fluid decompressing along a porous material. Either heat is absorbed from or released to the external environment. The exemplary embodiments may cool the mobile phase to a sub-ambient temperature before the mobile phase passes through a chromatography column to compensate for the frictional heating or heat the mobile phase to a super-ambient temperature to compensate for Joule-Thomson cooling. The amount of temperature increase expected from the frictional heating or the amount of temperature decrease expected from the Joule-Thomson cooling may be calculated or estimated. Based on the amount of temperature increase or decrease expected, the set point for the heater/cooler may be determined and applied to the mobile phase. The analyte may be injected solely into a central portion of the chromatography column to further compensate for thermal gradients.

公开(公告)号：US11994500B2

公开(公告)日：2024-05-28

申请号：US17084998

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Mark J. Basile ,  Jeffrey Musacchio ,  Michael O. Fogwill ,  Sebastien Besner ,  Joseph D. Michienzi ,  Wade P. Leveille

IPC: G01N30/74 ,  G01N30/30 ,  G01N30/02

CPC classification number: G01N30/74 ,  G01N30/30 ,  G01N2030/027 ,  G01N2030/3038 ,  G01N2030/746

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：US11986751B2

公开(公告)日：2024-05-21

申请号：US17241480

申请日：2021-04-27

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Wade P. Leveille, Sr. ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60

CPC classification number: B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

Abstract: Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.

公开(公告)号：US11951475B2

公开(公告)日：2024-04-09

申请号：US17325830

申请日：2021-05-20

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Charles T. Murphy ,  Joseph D. Michienzi

IPC: B01L3/00 ,  F16K99/00 ,  G01N30/02

CPC classification number: B01L3/502715 ,  F16K99/0013 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N2030/027

Abstract: Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels. Each fluid channel includes a channel segment defined in a plane that is parallel to the device surface and parallel to each of the planes of the other channel segments. The plane of each channel segment is at a depth below the device surface that is different from the depth below the device surface for the other planes. Each channel segment may have a volume equal to the volume of each of the other channel segments. One of the fluid channels may include a plurality of channel segments serially connected to each other and each defined in a plane that is different from the planes of the other channel segments.

公开(公告)号：US20220128526A1

公开(公告)日：2022-04-28

申请号：US17513003

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Sylvain G. Cormier ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Joseph D. Antocci

IPC: G01N30/60 ,  B01D15/22

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

公开(公告)号：US20210362153A1

公开(公告)日：2021-11-25

申请号：US17325830

申请日：2021-05-20

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Charles T. Murphy ,  Joseph D. Michienzi

IPC: B01L3/00

Abstract: Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels. Each fluid channel includes a channel segment defined in a plane that is parallel to the device surface and parallel to each of the planes of the other channel segments. The plane of each channel segment is at a depth below the device surface that is different from the depth below the device surface for the other planes. Each channel segment may have a volume equal to the volume of each of the other channel segments. One of the fluid channels may include a plurality of channel segments serially connected to each other and each defined in a plane that is different from the planes of the other channel segments.