公开(公告)号：USD838115S1

公开(公告)日：2019-01-15

申请号：US29588222

申请日：2016-12-19

Applicant: Geoffrey Adams

Designer： Geoffrey Adams

公开(公告)号：US09968698B2

公开(公告)日：2018-05-15

申请号：US14533612

申请日：2014-11-05

Applicant: STC.UNM

Inventor： David G. Whitten ,  Eric H. Hill ,  Harry C. Pappas

IPC: A61L2/18 ,  A01N41/04 ,  A01N33/12

CPC classification number: A61L2/18 ,  A01N33/12 ,  A01N41/04 ,  A01N25/30 ,  A01N41/02

Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.

公开(公告)号：US09958252B1

公开(公告)日：2018-05-01

申请号：US15642911

申请日：2017-07-06

Applicant: STC.UNM

Inventor： Jean-Claude Diels ,  Ladan Arissian

IPC: G01B9/02 ,  H01S3/106 ,  H01S3/108 ,  G02F1/39 ,  H01S3/067 ,  H01S3/086

CPC classification number: G01B9/02049 ,  G01B9/02015 ,  G02F1/39 ,  H01S3/0014 ,  H01S3/06712 ,  H01S3/082 ,  H01S3/086 ,  H01S3/106 ,  H01S3/1062 ,  H01S3/1083 ,  H01S3/1118

Abstract: Apparatus, systems, and methods of operating a fiber laser having polarization-preserving fibers can be applied as a sensor to detect a physical quantity. In various embodiments, polarization-preserving fibers can provide a laser cavity having an interferometer disposed in the laser cavity. In various embodiments, a fiber optical parametric oscillator can include an interferometer disposed in the cavity of the optical parametric oscillator. Additional apparatus, systems, and methods are disclosed.

公开(公告)号：US09435804B2

公开(公告)日：2016-09-06

申请号：US13967259

申请日：2013-08-14

Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada ,  STC.UNM ,  Regents of the University of Minnesota

Inventor： Thomas Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R Blazar ,  Julie A Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Rick Lyons

IPC: G01N33/53 ,  A61K39/07 ,  A01K39/02 ,  G01N33/569

CPC classification number: G01N33/56911 ,  A61K39/07 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6081 ,  C07K16/1278 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2317/92 ,  G01N2333/32 ,  A61K2300/00

Abstract: Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

Abstract translation: 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

公开(公告)号：US20160168632A1

公开(公告)日：2016-06-16

申请号：US14909582

申请日：2014-08-01

Applicant: Jeremy Scott EDWARDS ,  STC.UNM

Inventor： Jeremy Scott Edwards

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6825 ,  C12Q1/6841 ,  C12Q2523/303 ,  C12Q2543/10 ,  C12Q2523/307

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract translation: 本公开在一个方面描述了用于DNA测序和进行表观基因组分析的方法。 通常，所述方法包括将多个拷贝的DNA分子固定在表面上，拉伸固定的DNA分子的至少一部分，以及测序至少一部分固定的，拉伸的DNA分子。

公开(公告)号：US20140322166A1

公开(公告)日：2014-10-30

申请号：US14364182

申请日：2012-12-12

Applicant: STC. UNM ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA on behalf CHILDREN'S ONCOLOGY GROUP

Inventor： Cheryl L. Willman ,  Stephen P. Hunger ,  Charles Mullighan ,  I-Ming Chen ,  Kathryn G. Roberts ,  Huining Kang ,  Richard C. Harvey

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The invention provides arrays, systems, devices, methods, computer-readable media and kits that enable expression-based classification of B-precursor acute lymphoblastic leukemia (ALL) as being either responsive or non-responsive to tyrosine kinase inhibitor mono or co-therapy.

Abstract translation: 本发明提供阵列，系统，装置，方法，计算机可读介质和试剂盒，使基于B细胞的急性成淋巴细胞白血病（ALL）的基于表达的分类是对酪氨酸激酶抑制剂单一或共同治疗有反应或无反应 。

公开(公告)号：US08384381B2

公开(公告)日：2013-02-26

申请号：US12720499

申请日：2010-03-09

Applicant: Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

IPC: G01V3/00

CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

公开(公告)号：US20130011765A1

公开(公告)日：2013-01-10

申请号：US13636606

申请日：2011-03-23

Applicant: Koichiro Asazawa ,  Koji Yamada ,  Hirohisa Tanaka ,  Kazuya Yamamoto ,  Tim Olson ,  Svitlana Pylypenko ,  Plamen Atanassov

Inventor： Koichiro Asazawa ,  Koji Yamada ,  Hirohisa Tanaka ,  Kazuya Yamamoto ,  Tim Olson ,  Svitlana Pylypenko ,  Plamen Atanassov

IPC: H01M4/90 ,  H01M8/10

CPC classification number: H01M4/8605 ,  H01M4/8828 ,  H01M4/9008 ,  H01M4/9083 ,  H01M8/1011 ,  H01M2004/8689 ,  H01M2250/20 ,  Y02E60/523 ,  Y02T90/32

Abstract: In a fuel cell including an electrolyte layer allowing an anion component to migrate, and a fuel-side electrode and an oxygen-side electrode arranged to face each other while sandwiching the electrolyte layer, the oxygen-side electrode contains a first catalyst containing a first transition metal and polypyrrole, and a second catalyst containing a second transition metal and a porphyrin ring-containing compound so that the mixing ratio of the first catalyst relative to 100 parts by mass of the total amount of the first catalyst and the second catalyst is more than 10 parts by mass, and below 90 parts by mass.

Abstract translation: 在包含允许阴离子成分迁移的电解质层的燃料电池中，并且在夹着电解质层的同时配置为彼此面对的燃料侧电极和氧气侧电极，所述氧气侧电极含有含有第一催化剂的第一催化剂， 过渡金属和聚吡咯，以及含有第二过渡金属和含卟啉环的化合物的第二催化剂，使得第一催化剂与第一催化剂和第二催化剂的总量相对于100质量份的混合比更多 10质量份以下，90质量份以下。

公开(公告)号：US20130000640A1

公开(公告)日：2013-01-03

申请号：US13583606

申请日：2011-03-08

Applicant: Nicola Jeanne Maynard ,  Hugh D. Smyth

Inventor： Nicola Jeanne Maynard ,  Hugh D. Smyth

IPC: A61M15/00

CPC classification number: A61M15/0086 ,  A61M11/003 ,  A61M15/00 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/009 ,  A61M2016/0015 ,  A61M2202/064 ,  A61M2205/0272 ,  A61M2205/8287 ,  A61M2206/16

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

公开(公告)号：US20120001153A1

公开(公告)日：2012-01-05

申请号：US13231559

申请日：2011-09-13

Applicant: Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

Inventor： Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

IPC: H01L29/15 ,  H01L29/12 ,  B82Y99/00

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的提供约10nm至约1000微米的均匀长度的III-N族纳米线和/或纳米线阵列，其具有恒定的横截面特征，包括约10-1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。