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公开(公告)号：US20240150392A1
公开(公告)日：2024-05-09
申请号：US18228604
申请日：2023-07-31
Inventor： Dongran HAN , Hao YAN
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20240149275A1
公开(公告)日：2024-05-09
申请号：US18479220
申请日：2023-10-02
Inventor： Mark Hayes , Claire Crowther , Paul Jones
CPC classification number: B03C5/026 , B01L3/502753 , B03C5/005 , G01N15/1023 , G01N15/1484 , G01N27/447 , G01N27/44791 , B01L2400/0424 , B01L2400/086 , G01N2015/1006
Abstract: The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
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公开(公告)号：US11970683B2
公开(公告)日：2024-04-30
申请号：US16809384
申请日：2020-03-04
Inventor： Bruce Rittmann , Everett Eustance , Yen-Jung Lai , Justin Flory , Diana Calvo Martinez , Tarun Shesh
Abstract: Disclosed herein are methods and systems for membrane carbonation for cultivating microalgae and other microorganisms that utilize a gaseous substrate, as well as to upgrade the quality of mixed-gas streams.
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44.发明公开公开(公告)号：US20240134728A1
公开(公告)日：2024-04-25
申请号：US18496880
申请日：2023-10-29
Inventor： Paulo Shakarian , Mohammed Almukaynizi , Jana Shakarian , Eric Nunes , Krishna Dharaiya , Manoj Balasubramaniam Senguttuvan , Alexander Grimm
CPC classification number: G06F11/008 , G06F18/2148 , G06F18/24 , G06F21/54 , G06F21/552 , G06F21/577
Abstract: Various embodiments for predicting which software vulnerabilities will be exploited by malicious hackers and hence prioritized by patching are disclosed.
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45.发明公开公开(公告)号：US20240134025A1
公开(公告)日：2024-04-25
申请号：US18491367
申请日：2023-10-19
Applicant: Arizona Board of Regents on Behalf of Arizona State University , Texas Instruments Incorporated
Inventor： Sule Ozev , Ferhat C. Ataman , Chethan Kumar Y.B. , Sandeep Rao
Abstract: A radar system applies various angle correction processes with varying levels of computational overhead to reduce errors in angle estimation when processing received return signals. The various angle correction processes aim to overcome systematic errors affected by range migration through correction based on simulation or hardware measurements, through non-iterative refinement, iterative refinement, and/or a combination of correction and iterative refinement.
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Patent Agency Ranking
46.发明公开公开(公告)号：US20240102113A1
公开(公告)日：2024-03-28
申请号：US18255731
申请日：2021-12-02
Inventor： Karen ANDERSON , Mark KNAPPENBERGER , Siril AROCKIAM
IPC: C12Q1/70 , C12N9/22 , C12N15/11 , C12Q1/6818
CPC classification number: C12Q1/70 , C12N9/22 , C12N15/11 , C12Q1/6818 , C12Q1/6806
Abstract: The disclosure relates to methods of detecting a target nucleic acid in a sample using a deactivated RNA-guided nuclease and guide RNA complex. Some methods relate to isolating protein-nucleic acid complexes using silica-based chromatography with certain buffered solutions to better prevent complex dissociation. Some methods relate to isolating protein-nucleic acid complexes using a tagged ribonucleoprotein which binds to a target nucleic acid to form a detectable interconnected network comprising the target nucleic acid. Also provided herein are primer nucleic acids, buffer solutions, and kits for performing the methods of this disclosure for detecting a target nucleic acid in a sample.
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47.发明公开公开(公告)号：US20240099779A1
公开(公告)日：2024-03-28
申请号：US18525693
申请日：2023-11-30
Inventor： Lena Mary Houlihan , David Naughton , Mark C. Preul
CPC classification number: A61B34/10 , A61B34/25 , A61B2034/107 , A61B2034/256
Abstract: Various embodiments of a system and associated method for determining a volume of surgical freedom using a plurality of three-dimensional extrema points along a surgical corridor in relation to a structure of interest are disclosed herein.
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公开(公告)号：US20240078434A1
公开(公告)日：2024-03-07
申请号：US18241811
申请日：2023-09-01
Inventor： Zuwei Guo , Nahid Ul Islam , Jianming Liang
IPC: G06N3/0895 , G06N3/0455 , G06T7/00 , G06V10/774 , G06V10/82 , G06V20/50 , G06V20/70
CPC classification number: G06N3/0895 , G06N3/0455 , G06T7/0012 , G06V10/774 , G06V10/82 , G06V20/50 , G06V20/70 , G06T2207/20081 , G06T2207/20084 , G06T2207/30004 , G06V2201/03
Abstract: The system receives a plurality of medical images and integrates Self-Supervised machine Learning (SSL) instructions for performing a discriminative learning operation, a restorative learning operation, and an adversarial learning operation into a model for processing the received plurality of medical images. The model is configured with each of a discriminative encoder, a restorative decoder, and an adversarial encoder. Each of the discriminative encoder and the restorative decoder are configured to be skip connected, forming an encoder-decoder. Step-wise incremental training to incrementally train each of the discriminative encoder, the restorative decoder, and the adversarial encoder is performed, in particular: pre-training the discriminative encoder via discriminative learning; attaching the pre-trained discriminative encoder to the restorative decoder to configure the encoder-decoder as a pre-trained encoder-decoder; and training the pre-trained encoder-decoder of the model using joint discriminative and restorative learning. The pre-trained encoder-decoder is associated with the adversarial encoder. The pre-trained encoder-decoder associated with the adversarial encoder is trained through discriminative, restorative, and adversarial learning to render a trained model for the processing of the received plurality of medical images. The plurality of medical images are processed through the model using the trained model.
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公开(公告)号：US11915837B2
公开(公告)日：2024-02-27
申请号：US17378094
申请日：2021-07-16
Inventor： William Graves , Lucas Malin
IPC: G21K1/06 , H01S4/00 , H05G2/00 , G01N23/20008
CPC classification number: G21K1/062 , G01N23/20008 , H01S4/00 , H05G2/008 , G01N2223/0565 , G01N2223/102 , G21K2201/061 , G21K2201/067
Abstract: A method includes simulating diffraction in a transmission geometry of relativistic electron bunches from a crystallographic structure of a crystal thereby simulating diffraction of the relativistic electron bunches into a plurality of Bragg peaks. The method includes selecting a range of angles between a direction of propagation of the relativistic electron bunches and a normal direction of crystal including an angle at which a diffraction portion is maximized. The method includes sequentially accelerating a plurality of physical electron bunches to relativistic energies toward a physical crystal having the crystallographic structure and diffracting the plurality of physical electron bunches off the physical crystal at different angles and measuring the diffraction portion into the respective Bragg peak at the different angles. The method includes selecting a final angle based on the measured diffraction portion into the respective Bragg peak at the different angles and generating a pulse of light.
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公开(公告)号：US11913070B2
公开(公告)日：2024-02-27
申请号：US17184201
申请日：2021-02-24
Inventor： Stuart Lindsay
IPC: C12Q1/6869 , C12Q1/00 , G16B30/20 , G16B40/10 , G01N33/487 , G01N27/12
CPC classification number: C12Q1/6869 , C12Q1/005 , G01N33/48721 , G16B30/20 , G16B40/10 , G01N27/125
Abstract: The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer.
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