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    Receptor fingerprinting, sensory perception, and biosensors of chemical sensants
    41.
    发明授权
    Receptor fingerprinting, sensory perception, and biosensors of chemical sensants 有权
    受体指纹图谱，感官知觉和化学感受器的生物传感器

    公开(公告)号：US07374878B2

    公开(公告)日：2008-05-20

    申请号：US09886055

    申请日：2001-06-22

    Applicant: Lubert Stryer ,  Sergey Zozulya

    Inventor： Lubert Stryer ,  Sergey Zozulya

    IPC: C12Q1/68

    CPC classification number: G01N33/76 ,  G01N33/566 ,  G01N2333/726

    Abstract: The use of sensory G protein-coupled receptors that recognize chemical sensants, parti-cularly those involving olfactory and taste receptors; polypeptide fragments and mutants thereof; classes of such receptors; polynucleotides encoding such receptors, fragments and mutants thereof, and representatives of receptor classes; genetic vectors including such polynucleotides; and cells and non-human organisms engineered to express such receptor complexes, fragments and mutants of an olfactory or taste receptor, and representatives of receptor classes to simulate sensory perception of odorants and tastants is described. The use of such products as a biosensor or a component thereof to detect, identify, measure, or otherwise process the event of binding between the receptor and its cognate ligand (i.e., chemical sensant) is also described. The invention has application, for example, in the design and formulation of odorant and tastant compositions.

    Abstract translation: 使用识别化学感觉的感官G蛋白偶联受体，特别是那些涉及嗅觉和味觉受体的受体; 多肽片段及其突变体; 类受体; 编码这种受体的多核苷酸，其片段和突变体，以及受体类别的代表; 包括这种多核苷酸的遗传载体; 描述了工程化以表达这种受体复合物，嗅觉或味觉受体的片段和突变体的细胞和非人生物以及受体类的代表以模拟气味剂和促味剂的感觉知觉。 还描述了使用这样的产物作为生物传感器或其组分来检测，鉴定，测量或以其他方式处理受体与其同源配体（即化学感觉剂）之间结合的事件。 本发明可用于例如加臭剂和促味剂组合物的设计和配制。

    Computer-aided nucleic acid sequencing
    42.
    发明申请
    Computer-aided nucleic acid sequencing 审中-公开

    公开(公告)号：US20060194224A1

    公开(公告)日：2006-08-31

    申请号：US11300196

    申请日：2005-12-13

    Applicant: Lubert Stryer

    Inventor： Lubert Stryer

    IPC: C12Q1/68 ,  G06F19/00

    CPC classification number: C12Q1/6874 ,  G16B25/00 ,  G16B30/00 ,  C12Q2565/601

    Abstract: A computer system for sequencing nucleic acids is provided. The computer system may be used for de novo sequencing of a nucleic acid sequence by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. The probes with the highest intensities are utilized to sequence the nucleic acid and related probes are analyzed to increase the accuracy of nucleic acid sequencing. The sequence of the nucleic acid sequence may be determined from hybridization intensities that do not allow identification of perfectly complementary probes.

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