公开(公告)号：US20050112745A1

公开(公告)日：2005-05-26

申请号：US10976440

申请日：2004-10-29

Applicant: Preeti Lal ,  Y. Tang ,  Henry Yue ,  Neil Burford ,  Ameena Gandhi ,  Bridget Warren ,  Monique Yao ,  Catherine Tribouley ,  Mariah Baughn ,  Ernestine Lee ,  April Hafalia ,  Yan Lu ,  Jennifer Griffin ,  Madhusudan Sanjanwala ,  Li Ding

Inventor： Preeti Lal ,  Y. Tang ,  Henry Yue ,  Neil Burford ,  Ameena Gandhi ,  Bridget Warren ,  Monique Yao ,  Catherine Tribouley ,  Mariah Baughn ,  Ernestine Lee ,  April Hafalia ,  Yan Lu ,  Jennifer Griffin ,  Madhusudan Sanjanwala ,  Li Ding

IPC: A61K38/00 ,  A61K48/00 ,  C12N9/10 ,  C40B40/10 ,  A61K38/48 ,  C07H21/04

CPC classification number: C12N9/10 ,  A61K38/00 ,  A61K48/00 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C40B40/10

Abstract: The invention provides human transferases (TRNFR) and polynucleotides which identify and encode TRNFR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRNFR.

Abstract translation: 本发明提供鉴定和编码TRNFR的人转移酶（TRNFR）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与TRNFR异常表达相关的紊乱的方法。

公开(公告)号：US5961990A

公开(公告)日：1999-10-05

申请号：US850167

申请日：1997-05-02

Applicant: Pascal Delrieu ,  Li Ding

Inventor： Pascal Delrieu ,  Li Ding

IPC: A61K8/02 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/29 ,  A61K8/33 ,  A61K8/36 ,  A61K8/49 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/73 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61K9/14

CPC classification number: A61K8/042 ,  A61K8/0287 ,  A61K8/73 ,  A61K8/737 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2800/56 ,  A61K2800/654 ,  Y10S514/937 ,  Y10S514/944

Abstract: A protective cosmetic particulate gel delivery system for a topically applied active agent employs an agar gel and a restraining polymer to retain the actve agent in the gel. The particles have an average particle diameter of at least 0.05 mm while the restraining polymer has a molecular weight of at least 50,000 daltons and has retention groups to bind the active agent. The restraining polymers can be selected from the group consisting of polyquaternium 24, laurdimonium hydroxyethylcellulose, cocodimonium hydroxyethylcellulose, steardimonium hydroxyethylcellulose, quaternary ammonium substituted water-soluble polysaccharides, alleyl quaternary celluloses and polypeptides having or provided with retention groups to retain the active agent. The gel particles of the invention are manually crushable on the skin to increase the surface area of the gel particle material and expose the restraining polymer to the skin or other body surface for release of the active agent. The delivery system can be incorporated in multiphase cosmetic formulations such as gels, creams and lotions.

Abstract translation: 用于局部施用的活性剂的保护性化妆品颗粒状凝胶递送系统使用琼脂凝胶和约束聚合物将活性剂保留在凝胶中。 颗粒的平均粒径至少为0.05mm，而抑制聚合物的分子量至少为50,000道尔顿，并具有结合活性剂的保留基团。 约束聚合物可以选自聚季铵盐24，月桂基二甲基羟乙基纤维素，椰子二甲基羟乙基纤维素，聚对苯二甲酸羟乙基纤维素，季铵取代的水溶性多糖，等位基季铵纤维素和具有或具有保留活性剂的保留基团的多肽。 本发明的凝胶颗粒可手动压碎在皮肤上以增加凝胶颗粒材料的表面积，并将约束聚合物暴露于皮肤或其他身体表面以释放活性剂。 递送系统可以并入多相化妆品配方如凝胶，乳膏和洗剂中。

公开(公告)号：US10776725B2

公开(公告)日：2020-09-15

申请号：US12815375

申请日：2010-06-14

Applicant: Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

Inventor： Li Ding ,  Diana H. Lau ,  Elena H. Litani ,  Joanna W. Ng ,  Leho Nigul

IPC: G06F9/44 ,  G06Q10/04 ,  G06Q10/10

Abstract: A method for implementing a graphical modeling tool in a web-based environment is disclosed herein. In one embodiment, such a method may include enabling a user to import, into a web-based environment, a domain meta model comprising a number of meta model elements. The method may further enable the user to associate the meta model elements with graphical representations in the web-based environment, thereby allowing the user to create palette elements. The user may then assemble the palette elements on a canvas to create a diagram. This diagram may be converted into an instance of the domain meta model. This instance may be validated for conformance with the rules and constraints associated with the domain meta model. A corresponding apparatus and computer program product are also disclosed and claimed herein.

公开(公告)号：US20150378879A1

公开(公告)日：2015-12-31

申请号：US14319786

申请日：2014-06-30

Applicant: Li Ding

Inventor： Li Ding

IPC: G06F11/36

CPC classification number: G06F11/3688 ,  G06F11/3684

Abstract: An embodiment of a method of testing software can include, as performed by at least one computing device, evaluating a first criterion for a plurality of software components, selecting a subset of the plurality of software components based on the evaluated first criterion, evaluating a second criterion for a plurality of test cases each defining a respective test to evaluate functionality of at least one of the software components, selecting a subset of the plurality of test cases based on the evaluated second criterion, and testing the selected subset of the plurality of software components utilizing the selected subset of the plurality of test cases.

Abstract translation: 测试软件的方法的实施例可以包括如由至少一个计算设备执行的评估多个软件组件的第一标准，基于所评估的第一标准来选择所述多个软件组件的子集，评估第二标准 多个测试用例的标准，每个测试用例定义相应的测试以评估软件组件中的至少一个的功能，基于所评估的第二标准来选择多个测试用例的子集，以及测试所选择的多个软件的子集 使用多个测试用例的所选子集的组件。

公开(公告)号：US09060847B2

公开(公告)日：2015-06-23

申请号：US12380892

申请日：2009-03-04

Applicant: Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

Inventor： Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

IPC: B05D3/06 ,  A61L27/50 ,  A61L27/52 ,  A61F9/008 ,  B29D11/00 ,  A61F2/16

CPC classification number: A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.

公开(公告)号：US08759759B2

公开(公告)日：2014-06-24

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/00

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US08704170B2

公开(公告)日：2014-04-22

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/24 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US20130335424A1

公开(公告)日：2013-12-19

申请号：US13985834

申请日：2012-12-20

Applicant: Xiaolei Wang ,  Lei Zhang ,  Li Ding

Inventor： Xiaolei Wang ,  Lei Zhang ,  Li Ding

IPC: G06T11/60

CPC classification number: G06T11/60 ,  G06T11/203 ,  G09G5/28 ,  G09G2320/02 ,  G09G2360/16

Abstract: A character display technique relating to computer information processing to improve the display of characters. Whether a thickening process on a glyph outline corresponding to a character to be displayed is needed is determined by calculating a mean grayscale value of pixels of a grayscale bitmap of the glyph outline. if thickening is to be performed, the thickening amount is determined on the basis of the mean grayscale value of pixels, and the thickened glyph outline is output for display, thereby minimizing problems of fading of the displayed color, fuzzy strokes and the like due to strokes that are too narrow, and thus improving the character display effect.

Abstract translation: 与计算机信息处理相关的字符显示技术，以改善字符的显示。 通过计算字形轮廓的灰度位图的像素的平均灰度值来确定是否需要对应于要显示的字符的字形轮廓上的增稠处理。 如果要进行增厚，则基于像素的平均灰度值来确定增厚量，并且输出加粗的字形轮廓以进行显示，从而最小化由于显示的颜色，模糊笔画等引起的褪色的问题 笔画太窄，从而改善了人物的显示效果。

公开(公告)号：US20120310340A1

公开(公告)日：2012-12-06

申请号：US13238143

申请日：2011-09-21

Applicant: Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

Inventor： Wayne H. Knox ,  Thomas Smith ,  Dharmendra Jani ,  Li Ding

IPC: A61F2/16 ,  B29D11/00

CPC classification number: G02B3/0087 ,  A61F2/1618 ,  A61F2/1627 ,  A61F9/00834 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/18 ,  A61L2430/16 ,  G02B2003/0093 ,  G02C2202/12 ,  G02C2202/14 ,  C08L33/10

Abstract: A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

Abstract translation: 一种用于改变光学聚合物材料的折射率的方法。 该方法包括用飞秒激光脉冲连续照射光学聚合材料的预定区域，以在材料内形成梯度折射率折射结构。 光学装置包括具有前表面和后表面的光学聚合物透镜材料和与表面相交的光轴以及设置在前表面和后表面之间并且沿着第一轴线45布置的至少一个激光修饰的GRIN层 °至90°，并且进一步的特征在于，相邻段的至少一部分中的至少一个和沿着每个段的折射率的变化。

公开(公告)号：US08242459B2

公开(公告)日：2012-08-14

申请号：US13141864

申请日：2009-12-29

Applicant: Wenjian Sun ,  Xiaohui Yang ,  Li Ding

Inventor： Wenjian Sun ,  Xiaohui Yang ,  Li Ding

IPC: H01J27/08 ,  H01J49/04 ,  H05H1/24

CPC classification number: H01J49/168

Abstract: The current invention involves a desorption corona beam ionization source/device for analyzing samples under atmospheric pressure without sample pretreatment. It includes a gas source, a gas flow tube, a gas flow heater, a metal tube, a DC power supply and a sample support/holder for placing the samples. A visible corona beam is formed at a sharply pointed tip at the exit of the metal tube when a stream of inert gas flows through the metal tube that is applied with a high DC voltage. The gas is heated for desorbing the analyte from solid samples and the desorbed species are ionized by the energized particles embedded in the corona beam. The ions formed are then transferred through an adjacent inlet into a mass spectrometer or other devices capable of analyzing ions. Visibility of the corona beam in the current invention greatly facilitates pinpointing a sampling area on the analyte and also makes profiling of sample surfaces possible.

Abstract translation: 本发明涉及一种解吸电晕束电离源/装置，用于在大气压力下分析样品而无需样品预处理。 其包括气体源，气体流管，气流加热器，金属管，直流电源和用于放置样品的样品支撑/保持器。 当惰性气体流过施加有高直流电压的金属管时，在金属管的出口处的尖锐尖端处形成可见的电晕束。 加热气体以从固体样品中解吸分析物，并且解吸物质被嵌入电晕束中的通电颗粒电离。 所形成的离子然后通过相邻入口转移到质谱仪或其他能够分析离子的装置中。 本发明中电晕束的可见性大大有助于精确分析分析物上的采样区域，并且还使得样品表面的轮廓成为可能。