公开(公告)号：US20180104410A1

公开(公告)日：2018-04-19

申请号：US15816559

申请日：2017-11-17

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Raghavendhar Gautham ,  Ning Yang ,  Rajiv Shah

IPC: A61M5/172 ,  A61B5/053 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61M5/142 ,  A61M5/158 ,  G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US09801576B2

公开(公告)日：2017-10-31

申请号：US15446886

申请日：2017-03-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/1495 ,  A61B5/145 ,  G01N27/416 ,  G01N27/02 ,  A61B5/053 ,  A61B5/1486 ,  A61B5/00 ,  G01N33/66 ,  G01N33/49

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170248542A1

公开(公告)日：2017-08-31

申请号：US15595687

申请日：2017-05-15

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Steven C. Jacks ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Megan E. Little ,  Daniel E. Pesantez ,  Rajiv Shah

IPC: G01N27/416 ,  A61B5/145

CPC classification number: G01N27/416 ,  A61B5/1451 ,  A61B5/14532 ,  A61B2562/02 ,  A61B2562/125 ,  C23C28/00 ,  C25D3/52 ,  C25D3/567 ,  C25D5/18 ,  C25D7/00 ,  G01N27/30 ,  G01N27/327

Abstract: A physiological characteristic sensor, a method for forming a physiological characteristic sensor, and a method for forming a platinum deposit having a rough surface are presented here. The method for forming a physiological characteristic sensor includes immersing a sensor electrode in a platinum electrolytic bath. Further, the method includes performing an electrodeposition process by sequentially applying a pulsed signal to the sensor electrode, wherein the pulsed signal includes a repeated cycle of a first current and a second current different from the first current, and applying a non-pulsed continuous signal to the sensor electrode, wherein the non-pulsed continuous signal includes a non-repeated application of a third current, to form a platinum deposit on the sensor electrode.

公开(公告)号：US09693722B2

公开(公告)日：2017-07-04

申请号：US15152838

申请日：2016-05-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Rebecca K. Gottlieb

IPC: A61B5/05 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  C23C14/20 ,  C23C14/34 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416

CPC classification number: A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

Abstract: A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

公开(公告)号：US20170181673A1

公开(公告)日：2017-06-29

申请号：US14980241

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20170181672A1

公开(公告)日：2017-06-29

申请号：US14980152

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61M5/172 ,  A61B5/00 ,  A61M5/142 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/4836 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/7225 ,  A61B5/7271 ,  A61B2560/0276 ,  A61B2560/029 ,  A61M5/142 ,  A61M5/1723

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US09645111B2

公开(公告)日：2017-05-09

申请号：US13778433

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Catherine M. Szyman ,  Michael E. Miller ,  Rajiv Shah

IPC: A61B5/05 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20170021100A1

公开(公告)日：2017-01-26

申请号：US15282731

申请日：2016-09-30

Applicant: Medtronic MiniMed, Inc.

Inventor： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

IPC: A61M5/172 ,  G06F19/00

CPC classification number: A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/3468 ,  G16H50/30

Abstract: A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

Abstract translation: 一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。 该算法计算具有比例，导数和基础速率分量的传送量。 可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。 交付量的安全限制可能包含在算法中。 该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。 生物状态由感测装置感测到，该感测装置向控制器提供信号。 所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

公开(公告)号：US20160174884A1

公开(公告)日：2016-06-23

申请号：US15057330

申请日：2016-03-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： REBECCA K. GOTTLIEB ,  Rajiv Shah ,  Katherine T. Wolfe ,  Eric Allan Larson

IPC: A61B5/145 ,  A61B17/34 ,  A61B5/1473

CPC classification number: A61B5/14532 ,  A61B5/1473 ,  A61B5/6849 ,  A61B17/3496 ,  A61M5/158 ,  A61M5/3243 ,  A61M25/0612 ,  A61M37/0069 ,  A61M2005/1585 ,  A61M2005/3247

Abstract: An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.

Abstract translation: 提供导引器用于将传感器引入患者体内。 导引器连接到传感器集线器。 当传感器毂和导引器连接时，导引针被暴露。 当传感器毂和导引器断开时，针盖和针相对于彼此移动，使得针盖基本上覆盖针，保护使用者免受针受伤。

公开(公告)号：US09213010B2

公开(公告)日：2015-12-15

申请号：US13778514

申请日：2013-02-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Ning Yang ,  Rajiv Shah

IPC: G01N21/00 ,  G01N27/02 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  G01N27/416 ,  A61B5/00 ,  A61B5/053 ,  A61M5/172 ,  A61M5/142

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Abstract translation: 应用诊断电化学阻抗谱（EIS）程序来测量一个或多个感测电极的阻抗相关参数的值。 这些参数可以包括实际阻抗，虚拟阻抗，阻抗幅度和/或相位角。 然后将阻抗相关参数的测量值用于执行传感器诊断，基于来自多个冗余感测电极的信号计算高度可靠的融合传感器葡萄糖值，校准传感器，在非常接近的一个或多个感测中检测干扰物 电极和测试电镀电极的表面积特性。 有利地，可以限定与特定频率范围基本上不依赖葡萄糖的阻抗相关参数。 专用集成电路（ASIC）能够基于基于EIS的参数测量实现基于EIS的诊断，融合算法和其他过程。