公开(公告)号：US09500623B2

公开(公告)日：2016-11-22

申请号：US14052815

申请日：2013-10-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: G01N24/00 ,  G01N27/62 ,  H01J49/04

CPC classification number: H01J49/045 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0445 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US09500572B2

公开(公告)日：2016-11-22

申请号：US13784094

申请日：2013-03-04

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  He Wang ,  Nicholas E. Manicke ,  Robert Graham Cooks ,  Qian Yang ,  Jiangjiang Liu

IPC: G01N1/28 ,  H01J49/16 ,  H01J49/00 ,  G01N1/10

CPC classification number: G01N33/492 ,  G01N1/10 ,  G01N1/28 ,  G01N1/286 ,  G01N33/48714 ,  G01N33/48785 ,  G01N33/491 ,  G01N2001/2893 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/16

Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. In certain embodiments, the invention provides a fluid dispenser that includes a fluid chamber. A portion of an inner wall of the chamber includes an internal standard. The chamber is configured such that fluid introduced to the chamber must interact with the portion of the chamber wall that includes the internal standard prior to flowing through an outlet of the chamber. The dispenser additionally includes a member coupled to the chamber such that it can control movement of fluid within the chamber.

Abstract translation: 本发明一般涉及一种包括内部标准的样品分配器及其使用方法。 在某些实施例中，本发明提供一种包括流体室的流体分配器。 室的内壁的一部分包括内标。 腔室被配置成使得引入腔室的流体必须在流过腔室的出口之前与包括内部标准的腔室壁的部分相互作用。 分配器还包括联接到室的构件，使得其可以控制腔室内的流体的运动。

公开(公告)号：US20160118236A1

公开(公告)日：2016-04-28

申请号：US14936197

申请日：2015-11-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: H01J49/04 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/04 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20160047831A1

公开(公告)日：2016-02-18

申请号：US14880623

申请日：2015-10-12

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Livia Schiavinato Eberlin ,  Christina Ramires Ferreira ,  Allison Lisa Dill ,  Demian R. Ifa

IPC: G01N33/92 ,  H01J49/16 ,  H01J49/00

CPC classification number: G01N33/92 ,  H01J49/0004 ,  H01J49/0036 ,  H01J49/142 ,  H01J49/165

Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.

Abstract translation: 本发明一般涉及质谱分析。 在某些实施方案中，本发明的方法涉及使用质谱技术分析含脂质样品，其中该技术利用在分析期间不破坏天然组织形态的液相。

公开(公告)号：US09184036B2

公开(公告)日：2015-11-10

申请号：US13887911

申请日：2013-05-06

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: G01N24/00 ,  H01J49/04 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/04 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

Abstract translation: 本发明一般涉及用于使离子产生与不连续大气界面的循环同步的方法和装置。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括产生样品离子的质谱探针，不连续大气界面和质量分析仪，其中该系统配置成使得离子形成与 不连续大气界面。

公开(公告)号：US20150309001A1

公开(公告)日：2015-10-29

申请号：US14426879

申请日：2014-01-23

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Robert Graham Cooks ,  Fred Paul Mark Jjunju ,  Anyin Li ,  Iman S. Roqan

IPC: G01N33/28 ,  H01J49/10 ,  H01J49/00

CPC classification number: G01N33/2823 ,  G01N30/724 ,  G01N30/7266 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/10 ,  H01J49/164

Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

Abstract translation: 本发明一般涉及分析原油的方法。 在某些实施方案中，本发明的方法涉及获得原油样品，并对原油样品进行质谱分析。 在某些实施方案中，该方法在没有任何样品预纯化步骤的情况下进行。

公开(公告)号：US20150136964A1

公开(公告)日：2015-05-21

申请号：US14391867

申请日：2013-05-16

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

IPC: H01J49/06 ,  H01J49/10

CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

Abstract translation: 本发明一般涉及用于聚焦或高于环境压力的离子的装置及其使用方法。 在某些实施例中，本发明提供了一种用于聚焦离子的装置，其包括具有空腔的电极，该电极内的至少一个入口配置成可操作地与电离源耦合，使得由电离源产生的放电注入到 电极和出口。 电极中的空腔成形为使得在向电极施加电压时，空腔内的离子被聚焦并引导到出口，该出口定位成使得出口的近端接收聚焦离子，并且远端 出口开放到环境压力。

公开(公告)号：US08859958B2

公开(公告)日：2014-10-14

申请号：US13727167

申请日：2012-12-26

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  He Wang ,  Nicholas E. Manicke ,  Robert Graham Cooks ,  Qian Yang ,  Jiangjiang Liu

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/00 ,  G01N1/00

CPC classification number: G01N33/6848 ,  G01N1/00 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/16 ,  H01J49/168

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.

公开(公告)号：US20140264004A1

公开(公告)日：2014-09-18

申请号：US14209304

申请日：2014-03-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Alan Keith Jarmusch ,  Kevin Scott Kerian

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/04 ,  G01N2001/028 ,  G01N2001/4038

Abstract: The invention generally relates to systems and methods for analyzing a sample using a mass spectrometry probe having a tip that is configured to contact a sample and retain a portion of the sample once the probe has been removed from the sample.

Abstract translation: 本发明一般涉及用于使用质谱探针分析样品的系统和方法，所述质谱探针具有配置为接触样品并且一旦探针从样品中移除就保留样品的一部分。

公开(公告)号：US08816275B2

公开(公告)日：2014-08-26

申请号：US14023531

申请日：2013-09-11

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  He Wang ,  Nicholas E. Manicke ,  Robert Graham Cooks ,  Qian Yang ,  Jiangjiang Liu

IPC: H01J49/04 ,  H01J49/16 ,  G01N1/00 ,  H01J49/00

CPC classification number: G01N33/6848 ,  G01N1/00 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/16 ,  H01J49/168

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.