Screening method for identifying an agent that modulates PIPKIgamma trafficking of E-cadherin
    41.
    发明申请
    Screening method for identifying an agent that modulates PIPKIgamma trafficking of E-cadherin 审中-公开
    用于鉴定调节P-cadherin运输的E-钙粘蛋白的药剂的筛选方法

    公开(公告)号:US20070161060A1

    公开(公告)日:2007-07-12

    申请号:US11516858

    申请日:2006-09-06

    CPC classification number: C12Q1/485 G01N33/574 G01N2500/00

    Abstract: The present disclosure teaches that PIPKIγ binds cadherins and adaptor protein μ-subunits and mediates trafficking of cadherins to and from the plasma membrane. Thus, the present invention relates to a method for identifying agents which modulate the trafficking or binding activities of a PIPKIγ. A method for diagnosing and prognosing a cancer derived from epithelial cells by detecting the amount and subcellular location of PIPKIγ is also provided as is a method for preventing or treating a disease or condition involving PIPKγ activity or cadherin localization.

    Abstract translation: 本公开内容教导了PIPKIγ结合钙粘蛋白和衔接蛋白mu亚单位,并介导钙粘着蛋白与血浆膜的运输。 因此,本发明涉及用于鉴定调节PIPKIγ的贩运或结合活性的试剂的方法。 还提供了通过检测PIPKIγ的量和亚细胞定位来诊断和预测来自上皮细胞的癌症的方法,其是预防或治疗涉及PIPKgamma活性或钙粘蛋白定位的疾病或病症的方法。

    Shutter-type covering for architectural openings
    48.
    发明申请
    Shutter-type covering for architectural openings 有权
    用于建筑开口的快门式覆盖物

    公开(公告)号:US20050072088A1

    公开(公告)日:2005-04-07

    申请号:US10479893

    申请日:2002-07-16

    CPC classification number: E06B7/086 E06B9/30 E06B9/386 Y10S160/902

    Abstract: A Venetian-style window blind (10) that resembles plantation style shutters is described. In a preferred embodiment, the headrail is shaped like the plurality of slats depending from it, is pivotally connected to the sides of a window frame by mounting brackets and has a hollow interior. Tilting of the plurality slats depending from the headrail is accomplished by vertically moving an actuator rod that is pivotally connected to the headrail. The plurality of slats are suspended from the headrail by a cord ladder to tilt in unison with the headrail. While tilting the blind assembly into the closed position, the headrail and depending slats also slide inwardly towards the windowpane. The slats are lifted through the actuation of a lift handle that is slidably attached to the actuator rod and contains therein a lock mechanism to hold the slats in a desired position.

    Abstract translation: 描述了类似于种植园百叶窗的威尼斯风格的窗帘(10)。 在一个优选实施例中,头架的形状类似于从其上悬垂的多个板条,通过安装支架枢转地连接到窗框的侧面并且具有中空的内部。 通过垂直移动枢转地连接到头轨的致动器杆来实现从头轨悬垂的多个板条的倾斜。 多个板条通过绳索从头轨悬挂以与头轨一致地倾斜。 在将盲板组件倾斜到关闭位置的同时,头枕和依靠的板条也朝向窗玻璃向内滑动。 板条通过可滑动地附接到致动器杆的提升手柄的致动被提升,并且在其中包含锁定机构以将板条保持在期望的位置。

    Vapor handling in printing
    50.
    发明授权
    Vapor handling in printing 失效
    印刷中的蒸气处理

    公开(公告)号:US06643220B2

    公开(公告)日:2003-11-04

    申请号:US10103248

    申请日:2002-03-21

    CPC classification number: B41J2/20 B41J2/17 B41J2/195

    Abstract: Apparatus and methods are disclosed for enabling vapor handling in printing. In certain implementations, for example, one or more volatiles emitted during an ink-based printing process may be condensed into one or more liquids. The one or more liquids may be directed into absorbent materials such that the combined liquids and absorbent materials form a substance that qualifies as a solid, as determined by a given solid definition or regulatory standard. In certain (alternative but non-exhaustive) implementations, the volatiles emitted during printing may include water and oil, with the oil vapor being condensed into a liquid and added to the absorbent materials while the water vapor is being forwarded under the force of, e.g., negative air pressure.

    Abstract translation: 公开了用于在印刷中实现蒸汽处理的装置和方法。 在某些实施方案中,例如,在基于油墨的印刷过程中发射的一种或多种挥发物可以被冷凝成一种或多种液体。 一种或多种液体可以被引导到吸收材料中,使得组合的液体和吸收材料形成符合固体的物质,如由给定的固体定义或调节标准所确定的。 在某些(替代但非穷举)的实施中,在印刷期间发射的挥发物可包括水和油,其中油蒸气被冷凝成液体并加入到吸收材料中,同时水蒸气在例如 ,负气压。

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