公开(公告)号：US20170354719A1

公开(公告)日：2017-12-14

申请号：US15686972

申请日：2017-08-25

申请人： YALE UNIVERSITY

发明人： Demetrios BRADDOCK ,  Ronald ALBRIGHT

IPC分类号： A61K38/46 ,  C12N9/16 ,  C12N9/14

CPC分类号： A61K38/465 ,  A61K38/46 ,  C07K2319/30 ,  C12N9/14 ,  C12N9/16 ,  C12Y301/04001 ,  C12Y306/01009

摘要： The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.

公开(公告)号：US20170340672A1

公开(公告)日：2017-11-30

申请号：US15669707

申请日：2017-08-04

申请人： The Regents of the University of California

发明人： Chia-Yung Wu ,  James Onuffer ,  Wendell A. Lim

IPC分类号： A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C12N9/90 ,  C12N9/14 ,  C12N5/0783 ,  C07K16/18 ,  A61K47/68 ,  C07K16/28 ,  A61K39/00

CPC分类号： A61K35/17 ,  A61K47/6891 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2866 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/33 ,  C07K2319/74 ,  C12N5/0636 ,  C12N9/14 ,  C12N9/90 ,  C12N2510/00 ,  C12Y502/01008

摘要： The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.

公开(公告)号：US20170333533A1

公开(公告)日：2017-11-23

申请号：US15671287

申请日：2017-08-08

申请人： YALE UNIVERSITY

发明人： Demetrios BRADDOCK ,  Ronald ALBRIGHT

IPC分类号： A61K38/46 ,  C12N9/16 ,  C12N9/14

CPC分类号： A61K38/465 ,  A61K38/46 ,  C07K2319/30 ,  C12N9/14 ,  C12N9/16 ,  C12Y301/04001 ,  C12Y306/01009

摘要： The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.

公开(公告)号：US20170274054A1

公开(公告)日：2017-09-28

申请号：US15480986

申请日：2017-04-06

申请人： YALE UNIVERSITY

发明人： Demetrios BRADDOCK ,  Ronald ALBRIGHT

IPC分类号： A61K38/46 ,  C12N9/14 ,  C12N9/22 ,  A61K45/06

CPC分类号： A61K38/46 ,  A61K45/06 ,  C12N9/14 ,  C12N9/16 ,  C12N9/22 ,  C12Q1/44 ,  C12Y301/04001 ,  C12Y306/01009 ,  C12Y306/01029 ,  G01N33/5023 ,  G01N2333/916 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.

公开(公告)号：US20170247420A1

公开(公告)日：2017-08-31

申请号：US15370144

申请日：2016-12-06

申请人： Oral Health Australia Pty Ltd.

发明人： Eric Charles Reynolds ,  Neil Martin O'Brien Simpson ,  Keith J. Cross ,  Nada Slakeski

IPC分类号： C07K14/195 ,  C12N9/52 ,  G01N33/569 ,  A61K39/02 ,  C07K16/12

CPC分类号： C07K14/195 ,  A61K39/0216 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K16/1203 ,  C07K16/1257 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C12N9/14 ,  C12N9/52 ,  C12Y304/21 ,  C12Y304/21004 ,  C12Y306/05002 ,  G01N33/56955 ,  G01N2333/95

摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.

公开(公告)号：US09730977B2

公开(公告)日：2017-08-15

申请号：US14988403

申请日：2016-01-05

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Daria Mochly-Rosen ,  Xin Qi ,  Nir Qvit

IPC分类号： A61K38/08 ,  G01N33/573 ,  C07K7/06 ,  C07K14/705 ,  C07K14/00 ,  C07K14/47 ,  A61K38/16 ,  C07K7/08 ,  C12N9/14 ,  C12Q1/34 ,  A61K38/00 ,  A61K51/08

CPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/16 ,  A61K51/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4722 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/14 ,  C12Q1/34 ,  G01N33/573 ,  G01N2333/4703 ,  G01N2333/914 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

摘要： The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.

公开(公告)号：US20170175194A1

公开(公告)日：2017-06-22

申请号：US15347601

申请日：2016-11-09

申请人： MDNA Life Sciences Inc.

发明人： Andrew Harbottle ,  Gabriel Dakubo ,  Ryan L. Parr ,  Jennifer Creed ,  Brian Reguly ,  Kerry Robinson

IPC分类号： C12Q1/68 ,  C12N15/62

CPC分类号： C12Q1/6883 ,  C07K14/80 ,  C07K2319/00 ,  C12N9/0036 ,  C12N9/0053 ,  C12N9/12 ,  C12N9/14 ,  C12N15/62 ,  C12Q2600/148 ,  C12Q2600/156 ,  C12Y106/99003 ,  C12Y109/03001 ,  C12Y207/10001 ,  C12Y306/01003

摘要： The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.

公开(公告)号：US09676826B2

公开(公告)日：2017-06-13

申请号：US15098210

申请日：2016-04-13

申请人： TheVax Genetics Vaccine Co., Ltd.

发明人： Wei-I Chou ,  Chia-Mao Wu ,  Jiun-Ming Wu ,  Hsiu-Kang Chang

IPC分类号： C07K14/21 ,  C07K19/00 ,  A61K39/02 ,  A61K39/385 ,  A61K39/21 ,  C07K14/005 ,  A61K47/48 ,  C07K14/705 ,  A61K39/12 ,  A61K39/135 ,  A61K39/17 ,  C07K14/81 ,  C12N9/10 ,  C12N9/14 ,  A61K39/29 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/135 ,  A61K39/17 ,  A61K39/21 ,  A61K39/29 ,  A61K39/292 ,  A61K39/385 ,  A61K2039/57 ,  A61K2039/585 ,  A61K2039/6031 ,  C07K14/21 ,  C07K14/70596 ,  C07K14/81 ,  C07K2319/02 ,  C07K2319/04 ,  C07K2319/095 ,  C07K2319/33 ,  C07K2319/40 ,  C07K2319/55 ,  C12N9/1077 ,  C12N9/14 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2760/18134 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2770/24334 ,  C12N2770/32134 ,  C12Y204/02036 ,  C12Y306/05002 ,  Y02A50/386

摘要： A vaccine composition comprising a fusion protein for inducing enhanced pathogen antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, located at the N-terminus of the fusion protein; (b) a translocation peptide of 34-112 amino acid residues in length, comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 4, 2, 3, or 6, located at the C-terminus of the APC-binding domain or the CD91 receptor-binding domain; and (c) an antigen of a pathogen, located at the C-terminus of the translocation peptide; (d) a nuclear export signal, comprising the amino acid sequence of SEQ ID NO: 13; and (e) an endoplasmic reticulum retention sequence, located at the C-terminus of the fusion protein.

公开(公告)号：US09669247B2

公开(公告)日：2017-06-06

申请号：US14234824

申请日：2012-07-17

申请人： Shunpeng Li ,  Jian He ,  Baojian Hang

发明人： Shunpeng Li ,  Jian He ,  Baojian Hang

IPC分类号： C12N9/14 ,  C12N9/18 ,  A62D3/02 ,  C02F101/32 ,  C12N15/82 ,  C02F3/34 ,  A62D101/04 ,  A62D101/28 ,  A62D101/26 ,  C02F101/36

CPC分类号： A62D3/02 ,  A62D2101/04 ,  A62D2101/26 ,  A62D2101/28 ,  C02F3/342 ,  C02F2101/36 ,  C02F2101/40 ,  C12N9/14 ,  C12N9/18 ,  C12N15/8259 ,  C12N15/8274 ,  C12N15/8278

摘要： The present invention relates to the field of applied and environmental microorganism and agriculture. Disclosed are a thifensulfuron hydrolase gene tsmE and uses thereof. The thifensulfuron hydrolase gene tsmE has a nucleotide sequence of SEQ ID NO. 1, full length of 1194 bp, and G+C content of 51.09%, and encodes 398 amino acids with an amino acid sequence of SEQ ID NO. 2. The thifensulfuron hydrolase TsmE provided by the present invention can degrade completely 100 mg/L thifensulfuron within 1 hour into the herbicidally inactive product thiophenesulfonic acid; in addition, the TsmE also degrade completely 100 mg/L haloxyfop-R-methyl within 1 hour. Therefore, the thifensulfuron hydrolase gene tsmE is useful in construction of thifensulfuron-resistant transgenic crops and bioremediation of thifensulfuron or haloxyfop-R-methyl-contaminated environments.

公开(公告)号：US20170137793A1

公开(公告)日：2017-05-18

申请号：US15414291

申请日：2017-01-24

申请人： Promega Corporation

发明人： Aldis Darzins ,  Lance P. Encell ,  Rachel Friedman Ohana ,  Paul Otto ,  Michael R. Slater ,  Gediminas Vidugiris ,  Keith V. Wood ,  Monika G. Wood ,  Kate Qin Zhao ,  Kris Zimmerman

IPC分类号： C12N9/14 ,  C12N9/96 ,  C12N11/00

CPC分类号： C12N9/14 ,  C12N9/96 ,  C12N11/00 ,  C12Q1/34 ,  C12Y308/01 ,  G01N33/581

摘要： The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.