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211 条记录 (耗时 0.031 秒)

    Desferrithiocin derivatives and methods of use thereof
    42.
    发明授权
    Desferrithiocin derivatives and methods of use thereof 失效
    脱铁硫代衍生物及其使用方法

    公开(公告)号：US08604216B2

    公开(公告)日：2013-12-10

    申请号：US11367042

    申请日：2006-03-02

    申请人： Raymond J. Bergeron, Jr.

    发明人： Raymond J. Bergeron, Jr.

    IPC分类号： A61K31/425 ,  C07D277/10

    CPC分类号： C07D277/12

    摘要： Compounds represented by structural formulas such as Structural Formula (I): are highly efficient in clearing excess iron from an organism. The invention also discloses methods of treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

    摘要翻译： 由结构式表示的化合物如结构式（I）：在从生物体中清除多余的铁中是高效的。 本发明还公开了治疗诸如金属过载，氧化应激和肿瘤和肿瘤前病症的病症的方法。

    Process for the preparation of substituted thiazolines and their intermediates
    45.
    发明授权
    Process for the preparation of substituted thiazolines and their intermediates 失效
    制备取代噻唑啉及其中间体的方法

    公开(公告)号：US06894170B2

    公开(公告)日：2005-05-17

    申请号：US10270324

    申请日：2002-10-15

    申请人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    发明人： Sylvia Krich ,  Alexander Rieder ,  Ferdinand Heu ,  Gerhard Steinbauer

    IPC分类号： C12P41/00 ,  C07B55/00 ,  C07B57/00 ,  C07C319/02 ,  C07C319/28 ,  C07C323/58 ,  C07D277/12 ,  C07D417/04 ,  C07D277/10

    CPC分类号： C07D417/04 ,  C07C319/02 ,  C07D277/12 ,  C07C323/58

    摘要： Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).

    摘要翻译： 制备式（I）的取代噻唑啉的方法，其中Ar是苯基，萘基，噻吩基，吡啶基或喹啉基，其可以任选地被一个或多个选自卤素，OH，苄氧基，C C 1 -C 4 - 亚烷基，C 1 -C 4 - 烷氧基，COOR 1 - 其中R 1是H或C 1 -C 4 - 烷基，通过将（S）-α-甲基半胱氨酸盐酸盐与 式（II）与式（III）的腈<？in-line-formula description =“In-line formula”end =“lead”？> Ar-CN <？in-line-formula description =“In- 其中Ar如上所定义，或其相应的C 1 -C 4 - 亚烷基亚氨酸酯，其中（S） - 式（II）的α-甲基半胱氨酸盐酸盐在合适的溶剂中与式（III）的腈或相应的C 1 -C 4 - 亚烷基亚氨基酯反应 在pH为6.5t的叔碱存在下进行 o 10在50℃直到回流温度，得到相应的式（I）噻唑啉，以及制备（S）-α-甲基半胱氨酸盐酸盐的方法及其用于制备式（I）的噻唑啉的用途 一世）。