-
51.
公开(公告)号:US20150032207A1
公开(公告)日:2015-01-29
申请号:US14114160
申请日:2012-04-27
申请人: Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
发明人: Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
CPC分类号: A61B17/2909 , A61B2017/2937 , A61B2017/2945 , A61B2017/305 , A61F2/14 , A61F2/4601 , A61F9/0017 , A61F9/00736 , A61K35/50 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/50 , A61L2430/16 , A61M1/12 , A61M5/14 , A61M2202/09 , C12N5/0621 , C12N2506/02 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C08L65/04 , C08L89/00
摘要: Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译: 本文公开了用于将底物(包括细胞接种的底物)递送至需要治疗诱导细胞死亡,损伤或功能丧失的各种疾病的靶组织的仪器和方法。 衬底被配置为提供包括干细胞的细胞,其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。
-
公开(公告)号:US08920376B2
公开(公告)日:2014-12-30
申请号:US13091031
申请日:2011-04-20
申请人: Sean Caffey , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
发明人: Sean Caffey , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
CPC分类号: A61M5/14526 , A61M5/14248 , A61M5/14276 , A61M5/14593 , A61M5/1684 , A61M5/16886 , A61M2005/14204 , A61M2205/3523 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2210/0612
摘要: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
摘要翻译: 可以使用与储存器边界相关联的机械和/或磁性位置传感器来确定药物泵装置中药物储存器的填充状态。
-
53.
公开(公告)号:US08815092B2
公开(公告)日:2014-08-26
申请号:US13340516
申请日:2011-12-29
申请人: Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人: Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
CPC分类号: B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译: 一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。 多孔膜由聚对二甲苯形成并使用微细加工技术组装。 多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。
-
公开(公告)号:US20130317607A1
公开(公告)日:2013-11-28
申请号:US13896539
申请日:2013-05-17
申请人: Charles DeBoer , Yu-Chong Tai , Mark S. Humayun
发明人: Charles DeBoer , Yu-Chong Tai , Mark S. Humayun
IPC分类号: A61F2/16
CPC分类号: A61F2/1613 , A61F2/1616 , A61F2/1624 , A61F2/1629 , A61F2/1635 , A61F2/1648 , A61F2002/1699
摘要: An implantable intraocular lens and methods of manufacturing them provide a target degree of optical accommodation. In various embodiments, the lens includes at least one internal optic, an outer shell for enclosing at least a portion of the internal optic, and a fluid at least partially filling the outer shell.
摘要翻译: 可植入眼内透镜及其制造方法提供目标光学适应度。 在各种实施例中,透镜包括至少一个内部光学元件,用于封闭内部光学元件的至少一部分的外壳以及至少部分地填充外壳的流体。
-
公开(公告)号:US08585630B2
公开(公告)日:2013-11-19
申请号:US13555329
申请日:2012-07-23
申请人: Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人: Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号: A61M5/00
CPC分类号: A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要: An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.
-
公开(公告)号:US08551425B2
公开(公告)日:2013-10-08
申请号:US12784446
申请日:2010-05-20
申请人: Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
发明人: Amir Goldkorn , Yu-Chong Tai , Tong Xu , Bo Lu
CPC分类号: G01N33/57496 , C12N5/0693 , C12N2503/00 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Y207/07049 , G01N1/30 , G01N1/4077 , G01N33/5094 , G01N2001/4088 , G01N2333/9128 , Y10T436/25375
摘要: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要翻译: 本发明提供一种用于诊断癌症的方法,预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞(CTC),例如可行的CTC,所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器, 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。
-
公开(公告)号:US20120234433A1
公开(公告)日:2012-09-20
申请号:US13419968
申请日:2012-03-14
申请人: Jason Shih , Sean Caffey , Mark Humayun , Fukang Jiang , Changlin Pang , Raymond Peck , Yu-Chong Tai
发明人: Jason Shih , Sean Caffey , Mark Humayun , Fukang Jiang , Changlin Pang , Raymond Peck , Yu-Chong Tai
IPC分类号: B65B31/00
CPC分类号: A61M5/14276
摘要: A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir.
摘要翻译: 一种用于重新填充具有至少一个储存器的可植入泵的工具。 该工具包括多个独立的流体通道; 流体储存器,其与所述流体通道中的第一流体流体连通; 流体地联接到流体通道的至少一个泵,所述至少一个泵和独立流体通道在数量上彼此不同,其中(i)泵构造成对第一流体通道施加正压以驱动流体 并且(ii)泵构造成对第二流体通道施加负压; 以及用于将所述流体通道可移除地连接到所述至少一个储存器的连接器。
-
公开(公告)号:US08246569B1
公开(公告)日:2012-08-21
申请号:US11205757
申请日:2005-08-16
申请人: Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
发明人: Ellis Fan-chuin Meng , Po-Jui Chen , Damien Rodger , Yu-Chong Tai , Mark Humayun
IPC分类号: A61M5/00
CPC分类号: A61F9/00781 , A61B3/16 , A61B5/4836 , A61B5/6821 , A61B2562/0247 , A61B2562/028 , A61B2562/12 , F16K99/0009 , F16K99/0057 , F16K2099/0086
摘要: An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.
摘要翻译: 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端,允许多余的液体通过管排出眼睛。 在一个实施例中,仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压(IOP),例如利用植入的传感器。 当眼压超过临界值时,从业人员介入,用激光穿刺位于眼睛外部的管的薄化区域,从而引起流体排出并释放压力。 根据替代实施例,管的两端是开放的,并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。
-
公开(公告)号:US08231608B2
公开(公告)日:2012-07-31
申请号:US12463251
申请日:2009-05-08
申请人: Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人: Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
CPC分类号: A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要: Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
摘要翻译: 可植入电解泵的实施例包括第一可膨胀隔膜和第二柔性隔膜,以及每个用于容纳流体的第一和第二室,其中第一可膨胀隔膜分隔第一和第二室并在其间提供流体阻挡物,第二室 形成在第一可膨胀膜片和第二柔性膜片之间。 泵还可以包括在第一室内的电解电极,用于在其中产生气体,从而使可膨胀隔膜膨胀,使得流体被迫从第二室进入套管。
-
公开(公告)号:US20120064552A1
公开(公告)日:2012-03-15
申请号:US13232776
申请日:2011-09-14
申请人: Yu-Chong Tai , Wendian Shi , Luke Guo
发明人: Yu-Chong Tai , Wendian Shi , Luke Guo
CPC分类号: G01N33/86 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/0442 , B01L2400/0677 , F16K99/0032 , F16K99/004 , F16K2099/0084 , G01N33/49 , G01N2035/00247 , Y10T137/0391
摘要: The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve.
摘要翻译: 本发明提供了一种通过加热微流体装置的毛细管中的血液形成血块微血管的方法。 还描述了通过形成和除去血块微血管来调节毛细管中的液体流动的方法。
-
-
-
-
-
-
-
-
-