公开(公告)号：US20180373083A1

公开(公告)日：2018-12-27

申请号：US16065267

申请日：2016-12-16

Applicant: Centre National de la Recherche Scientifique (CNRS) ,  Universite Grenoble Alpes

Inventor： Tiphaine Belloir ,  Olivier Lecarme ,  Thibault Honegger

IPC: G02F1/1343

CPC classification number: G02F1/13439 ,  B82Y15/00 ,  G02F1/134309 ,  G02F2001/134318 ,  G02F2201/122

Abstract: The invention relates to an electro-optical device for detecting an electric field emitted locally by a sample (100), comprising an upper (20) and a lower (21) polarizer, an active layer of liquid crystals (30) of variable polarization included between an upper (50) and a lower (51) alignment layer, having two perpendicular directions of alignment, and an upper (60) and lower (61) electrode liable to be connected to an AC voltage source (70) such that when a voltage difference (Vext) is applied, the layer of liquid crystals is immersed in the electric field formed between the two electrodes. It is essentially characterized in that it comprises a layer of anisotropic electrical conductors (40) in contact with the upper alignment layer or separated therefrom by the upper polarizer, the conductors being configured to transmit said electric field in only one direction secant to the alignment layers.

公开(公告)号：US20180347057A1

公开(公告)日：2018-12-06

申请号：US15967454

申请日：2018-04-30

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Wei Gao ,  Sirilak Sattayasamitsathit

IPC: C25D1/02 ,  G01N33/487 ,  B01J35/02 ,  A61K47/02 ,  A61K47/34 ,  B01J20/22 ,  C25D3/12 ,  C25D1/20 ,  C25D1/00 ,  B82Y30/00 ,  B01J37/02 ,  A61K9/70 ,  B01J35/00 ,  B01J31/06 ,  B01J23/89 ,  B01J23/42 ,  B82Y15/00 ,  F03H99/00

CPC classification number: C25D1/02 ,  A61K9/70 ,  A61K47/02 ,  A61K47/34 ,  B01J20/22 ,  B01J23/42 ,  B01J23/8906 ,  B01J23/8913 ,  B01J23/892 ,  B01J31/06 ,  B01J35/0006 ,  B01J35/0033 ,  B01J35/02 ,  B01J37/0215 ,  B01J37/0244 ,  B01J2231/005 ,  B01J2531/005 ,  B82Y15/00 ,  B82Y30/00 ,  C25D1/006 ,  C25D1/20 ,  C25D3/12 ,  F03H99/00 ,  G01N33/48707

Abstract: Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble-induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.

公开(公告)号：US20180344164A1

公开(公告)日：2018-12-06

申请号：US15778236

申请日：2016-11-23

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Ming LI ,  Ishan BARMAN ,  Martin POMPER ,  Sangeeta RAY

IPC: A61B5/00 ,  G01N33/543 ,  G01N33/574 ,  A61B1/06 ,  G01N21/65

CPC classification number: G01N33/574 ,  B82Y15/00 ,  G01N21/658 ,  G01N33/54346

Abstract: The present invention provides a targeted nanoplex platform for in vivo imaging and theranostic imaging of cancer to simultaneously provide non-invasive assessment of tumor burden and cancer-selective treatments.

公开(公告)号：US20180339321A1

公开(公告)日：2018-11-29

申请号：US15810483

申请日：2017-11-13

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Steven J. Holmes ,  Emily R. Kinser ,  Qinghuang Lin ,  Nathan P. Marchack ,  Roy R. Yu

IPC: B08B17/02 ,  A61B5/00 ,  A61B5/04

CPC classification number: B08B17/02 ,  A61B5/04001 ,  A61B5/4839 ,  A61B2562/0209 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/125 ,  B08B17/065 ,  B82Y15/00 ,  B82Y40/00

Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.

公开(公告)号：US20180321231A1

公开(公告)日：2018-11-08

申请号：US16034892

申请日：2018-07-13

Applicant: Washington University

Inventor： Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

IPC: G01N33/543 ,  B82Y40/00 ,  G01N33/574 ,  G01N21/65 ,  B82Y20/00 ,  B82Y15/00 ,  G01N21/552 ,  B82Y5/00

CPC classification number: G01N33/54346 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/57438 ,  G01N2201/02

Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

公开(公告)号：US20180321180A1

公开(公告)日：2018-11-08

申请号：US15984158

申请日：2018-05-18

Applicant: ELECTRONIC BIOSCIENCES, INC.

Inventor： Eric N. Ervin ,  John J. Watkins ,  Geoffrey A. Barrall

IPC: G01N27/327 ,  G01N33/487 ,  G01N33/543

CPC classification number: G01N27/3278 ,  B82Y15/00 ,  G01N33/48721 ,  G01N33/54386 ,  G01N33/54393 ,  G01N33/551

Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.

公开(公告)号：US20180317415A1

公开(公告)日：2018-11-08

申请号：US15773166

申请日：2016-11-04

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Michael S. STRANO ,  Seongyeon KWAK ,  Juan Pablo Giraldo GOMEZ ,  Min Hao WONG

IPC: A01H3/00 ,  C12N9/02 ,  A01G7/00

CPC classification number: A01H3/00 ,  A01G7/00 ,  A01H5/00 ,  B82Y15/00 ,  C12N9/0069 ,  C12Y113/12007

Abstract: A plant nanobionic approach can utilize a system of four nanoparticle types, including luciferase conjugated silica, luciferin releasing poly(lactic-co-glycolic acid), coenzyme A functionalized chitosan, and semiconductor nanocrystal phosphors for wavelength modulation.

公开(公告)号：US20180307341A1

公开(公告)日：2018-10-25

申请号：US16020990

申请日：2018-06-27

Applicant: TPK Touch Solutions Inc.

Inventor： Shun-Jie Yang ,  Hong-Siang Shao ,  En-Chin Chang ,  Hsi-Chien Lin

IPC: G06F3/041

CPC classification number: G06F3/041 ,  B82Y15/00 ,  B82Y40/00 ,  C23F4/00 ,  G06F2203/04103 ,  H01L21/3065 ,  H01L21/321

Abstract: The present disclosure provides a touch-panel display device. The touch-panel device comprises a transparent substrate including a first surface and a second surface on opposite sides of the transparent substrate, respectively, a display module at the first surface side of the transparent substrate, and a first sensing electrode layer, disposed between the transparent substrate and the display module, including a first nanostructure layer having first regions and second regions, the first regions being electrically isolated from each other by the second regions, and a haze difference between the first regions and the second regions is not greater than 0.1%.

公开(公告)号：US20180275088A1

公开(公告)日：2018-09-27

申请号：US15726298

申请日：2017-10-05

Applicant: Abbott Laboratories

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Graham Davis ,  Sergey Gershtein

IPC: G01N27/327 ,  G01N33/487 ,  B01L3/00 ,  C12Q1/6869 ,  G01N33/543 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/16 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0427 ,  B82Y15/00 ,  C12Q1/004 ,  C12Q1/6869 ,  C40B60/12 ,  G01N21/78 ,  G01N27/3271 ,  G01N33/48707 ,  G01N33/48721 ,  G01N33/54326 ,  G01N33/5438 ,  G01N2021/6482 ,  G01N2021/825 ,  G01N2458/10

Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided. Also provided herein are instruments that are programmed to operate a cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region. The instrument may be used to analyse a sample in a cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore. An instrument configured to operate a first cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region and a second cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed. An instrument configured to operate a cartridge that includes an array of electrodes for actuating a droplet, an electrochemical species sensing region, and a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed.

公开(公告)号：US20180267049A1

公开(公告)日：2018-09-20

申请号：US15920115

申请日：2018-03-13

Applicant: King Fahd University of Petroleum and Minerals

Inventor： Tawfik A. SALEH ,  Mutasem M. AL-SHALAFEH ,  Abdulaziz A. AL-SAADI

IPC: G01N33/58 ,  G01N21/65

CPC classification number: G01N33/587 ,  B82Y5/00 ,  B82Y15/00 ,  G01N21/658 ,  G01N33/49 ,  G01N33/493 ,  G01N33/54373 ,  G01N33/94

Abstract: A method for analyzing or detecting methimazole (“MTZ”) comprising contacting a sample suspected of containing MTZ with the dendrimer-stabilized silver nanoparticles and performing surface-enhanced Raman scattering (SERS). Graphene-dendrimer-stabilized silver nanoparticles (G-D-Ag).