公开(公告)号：US06465001B1

公开(公告)日：2002-10-15

申请号：US09033871

申请日：1998-03-03

Applicant: Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy ,  Jennifer L. Hill-West

Inventor： Jeffrey A. Hubbell ,  Chandrashekhar P. Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy ,  Jennifer L. Hill-West

IPC: A61F200

CPC classification number: C12N11/04 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61K38/42 ,  A61K38/44 ,  A61K47/645 ,  A61K47/6903 ,  A61K47/6927 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  B82Y5/00 ,  C08B37/003 ,  C08B37/0072 ,  C08B37/0084 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/08 ,  C08F290/10 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  Y10S514/801 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/815 ,  Y10S530/817 ,  Y10T428/2987 ,  Y10T428/2989 ,  C08L71/02

Abstract: Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, and coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules. A medical condition at a localized site is treated by applying a polymerization initiator and then applying a substantially water-soluble, degradable macromer of at least 200 mw and having at least two crosslinkable substituents, and polymerizing the macromer to form a crosslinked polymeric material at the site. The crosslinked polymeric material may adhere two surfaces together, or be a barrier that provides immunoisolation or prevents adhesion of the site to another surface such as post-surgical adhesion. A biologically active material may be present when the macromer is polymerized to provide for delivery of the biologically active material, or to provide the polymeric material with a desired property such as resistance to bacterial growth or a decrease in inflammatory response.

Abstract translation: 通过添加可自由基聚合的基团（例如含有碳 - 碳双键或三键的那些基团）来修饰水溶性大分子单体，其可在温和条件下聚合以包封组织，细胞或生物活性材料。 聚合物材料特别可用作组织粘合剂，包括血管的组织腔的涂层，诸如朗格汉斯岛的细胞的涂层，以及用于与生物材料如身体接触的涂层，塞子，支撑体或基底，以及作为药物递送装置 用于生物活性分子。 通过施加聚合引发剂然后施加至少200mw的基本上水溶性的可降解的大分子单体并且具有至少两个可交联取代基来处理局部位点处的医学状况，并聚合大分子单体以形成交联的聚合物材料 现场。 交联的聚合物材料可以将两个表面粘合在一起，或者是提供免疫隔离或防止位点粘附到另一表面的屏障，例如手术后粘连。 当大分子单体聚合以提供生物活性材料的递送时，或者为聚合物材料提供所需性质，例如耐细菌生长或炎症反应降低时，可存在生物活性物质。

公开(公告)号：US09242005B1

公开(公告)日：2016-01-26

申请号：US11507860

申请日：2006-08-21

Applicant: Syed Hossainy ,  Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny ,  Fozan El-Nounou ,  Thierry Glauser ,  Jessica DesNoyer

Inventor： Syed Hossainy ,  Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny ,  Fozan El-Nounou ,  Thierry Glauser ,  Jessica DesNoyer

IPC: A61M31/00 ,  A61K47/42 ,  A61K47/48 ,  A61M5/178

CPC classification number: A61K47/42 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/1273 ,  A61M5/178 ,  A61M25/104 ,  A61M31/00 ,  A61M2025/0087 ,  A61M2025/105 ,  A61M2025/1052

Abstract: Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.

Abstract translation: 本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。 在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。 在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。 在一些应用中，前修复剂可以帮助恢复内皮功能。 制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。

公开(公告)号：US20140018903A1

公开(公告)日：2014-01-16

申请号：US13549366

申请日：2012-07-13

Applicant: Erik David Eli ,  Michael Huy Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Dariush Davalian

Inventor： Erik David Eli ,  Michael Huy Ngo ,  Mikael Trollsas ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Dariush Davalian

IPC: A61F2/82

CPC classification number: A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0054

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings.

Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架具有当植入在外周血管内时产生较低的晚期管腔损失并且也表现出高的轴向疲劳寿命的结构。 在优选实施例中，支架形成通过连杆互连的环形结构，其中环具有12个冠部，并且至多两个连接相邻环件的连杆。

公开(公告)号：US08521259B2

公开(公告)日：2013-08-27

申请号：US10781984

申请日：2004-02-18

Applicant: Evgenia Mandrusov ,  Murthy V. Simhambhatla ,  Syed Hossainy ,  Eugene T. Michal ,  Charles Claude ,  Jessica G. Chiu

Inventor： Evgenia Mandrusov ,  Murthy V. Simhambhatla ,  Syed Hossainy ,  Eugene T. Michal ,  Charles Claude ,  Jessica G. Chiu

IPC: A61B5/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/4839 ,  A61B17/3478 ,  Y10S977/905 ,  Y10S977/915

Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.

Abstract translation: 一种包括将导管定位在血管中的位置的方法; 在该位置成像血管壁的一部分的厚度; 识别治疗部位; 将针距离进入血管壁至治疗部位; 并将治疗剂通过针引入治疗部位。 一种组合物，其包含炎症诱导剂和具有适于经血管递送的粒度的微球形式的载体。 一种包含载体中的治疗性血管生成促进剂和与载体偶联的调理蛋白抑制剂的组合物。 用于递送治疗性血管生成促进剂的装置。

公开(公告)号：US08480650B2

公开(公告)日：2013-07-09

申请号：US13098092

申请日：2011-04-29

Applicant: Kevin Ehrenreich ,  Jesus Magana ,  Paul Consigny ,  Syed Hossainy

Inventor： Kevin Ehrenreich ,  Jesus Magana ,  Paul Consigny ,  Syed Hossainy

IPC: A61M31/00

CPC classification number: A61M25/0021 ,  A61M25/1002 ,  A61M25/10184 ,  A61M25/10185 ,  A61M25/10187 ,  A61M25/104 ,  A61M2025/004 ,  A61M2025/0081 ,  A61M2025/105 ,  A61M2025/1088 ,  A61M2039/248

Abstract: A method for improving tissue uptake of beneficial agent and ejection fraction.

Abstract translation: 一种改善有益药物和射血分数的组织吸收的方法。

公开(公告)号：US08119184B2

公开(公告)日：2012-02-21

申请号：US12688571

申请日：2010-01-15

Applicant: Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

Inventor： Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

IPC: A61L33/00 ,  B05D3/12 ,  B05D3/10

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0095 ,  A61F2230/0013 ,  A61F2250/0025 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.

Abstract translation: 由支架支柱确定的可变表面积的支架。 支架可以具有容纳治疗剂的每单位长度的可变表面积。 可以在整个支架中提供治疗剂的图案化分布。 支架可以在支架的端部附近具有增加的治疗剂水平。 在支架的一个实施方案的末端附近可以提供降低的治疗剂水平。 可以在支架的表面设置缺陷，其中设置有治疗剂。 可以用可变厚度的支柱切割支架，以提供可变的支架表面积。

公开(公告)号：US20110143014A1

公开(公告)日：2011-06-16

申请号：US12636079

申请日：2009-12-11

Applicant: John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

Inventor： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

IPC: B05D7/00

CPC classification number: A61L29/085 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/16 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105

Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.

Abstract translation: 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

公开(公告)号：US07867549B2

公开(公告)日：2011-01-11

申请号：US12605251

申请日：2009-10-23

Applicant: Evgenia Mandrusov ,  Paul Consigny ,  Syed Hossainy ,  Dary Mirzaee

Inventor： Evgenia Mandrusov ,  Paul Consigny ,  Syed Hossainy ,  Dary Mirzaee

IPC: B05D1/02

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2250/0068 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/61

Abstract: A method of manufacturing a drug-delivery coating for a stent is disclosed. The method comprises covering the outer surface of the stent; applying a first composition to the inner surface of the stent to form a first coating; covering the first coating on the inner surface of the stent; and applying a second composition to the outer surface of the stent to form a second coating.

Abstract translation: 公开了制造用于支架的药物递送涂层的方法。 该方法包括覆盖支架的外表面; 将第一组合物施加到所述支架的内表面以形成第一涂层; 覆盖支架内表面上的第一涂层; 以及将第二组合物施加到所述支架的外表面以形成第二涂层。

公开(公告)号：US20100331819A1

公开(公告)日：2010-12-30

申请号：US12491063

申请日：2009-06-24

Applicant: Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

Inventor： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

IPC: A61M25/00 ,  A61K9/127 ,  A61K9/14 ,  A61K31/409 ,  A61K31/555 ,  A61K31/197 ,  A61K31/22 ,  A61P35/00

CPC classification number: A61K31/409 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K41/0071 ,  A61L29/16 ,  A61L2300/224 ,  A61L2300/626 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

Abstract: This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site.

Abstract translation: 本发明涉及光动力治疗（PDT），更具体地涉及通过将负载PDT的纳米颗粒（例如脂质体，聚合物囊泡，胶束和聚合物纳米颗粒）递送到患病血管组织中的动脉粥样硬化斑块的PDT。 本发明提供用于递送多种药物并将药物递送至特定目标部位的方法和制剂。

公开(公告)号：US20100116785A1

公开(公告)日：2010-05-13

申请号：US12688571

申请日：2010-01-15

Applicant: Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

Inventor： Syed Hossainy ,  Fuh-Wei Tang ,  Brian P. Cahill

IPC: B05D3/10 ,  C23F1/00

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0095 ,  A61F2230/0013 ,  A61F2250/0025 ,  A61F2250/0067 ,  A61F2250/0068

Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.

Abstract translation: 由支架支柱确定的可变表面积的支架。 支架可以具有容纳治疗剂的每单位长度的可变表面积。 可以在整个支架中提供治疗剂的图案化分布。 支架可以在支架的端部附近具有增加的治疗剂水平。 在支架的一个实施方案的末端附近可以提供降低的治疗剂水平。 可以在支架的表面设置缺陷，其中设置有治疗剂。 可以用可变厚度的支柱切割支架，以提供可变的支架表面积。