公开(公告)号：US08866125B2

公开(公告)日：2014-10-21

申请号：US13875264

申请日：2013-05-01

申请人： Stephen D. Hersee

发明人： Stephen D. Hersee

IPC分类号： H01L29/06 ,  H01L29/778 ,  H01L25/16 ,  H01L27/15 ,  H01L33/00 ,  H01L33/06 ,  H01L29/20

CPC分类号： H01L27/15 ,  H01L25/167 ,  H01L29/2003 ,  H01L29/7787 ,  H01L33/0041 ,  H01L33/06 ,  H01L2224/32225 ,  H01L2924/0002 ,  H01L2924/00

摘要： Various embodiments provide materials and methods for integrating exemplary heterostructure field-effect transistor (HFET) driver circuit or thyristor driver circuit with LED structures to reduce or eliminate resistance and/or inductance associated with their conventional connections.

摘要翻译： 各种实施例提供用于将示例性异质结构场效应晶体管（HFET）驱动器电路或晶闸管驱动器电路与LED结构集成以减少或消除与其常规连接相关联的电阻和/或电感的材料和方法。

公开(公告)号：US08864045B1

公开(公告)日：2014-10-21

申请号：US13300069

申请日：2011-11-18

申请人： Xingmao Jiang ,  C. Jeffrey Brinker

发明人： Xingmao Jiang ,  C. Jeffrey Brinker

IPC分类号： B05B1/24

CPC分类号： B05B1/24 ,  B22F1/0018 ,  B22F1/02 ,  B22F9/06 ,  B22F2001/0092 ,  C01B13/34 ,  C01B21/06 ,  C01P2004/32 ,  C01P2004/34 ,  C01P2004/64 ,  C22C2202/02 ,  C23C18/08 ,  C23C18/1204 ,  C23C18/1241 ,  C23C18/1245 ,  C23C18/127 ,  C23C18/1295

摘要： Exemplary embodiments provide materials and methods for forming monodisperse particles. In one embodiment, the monodisperse particles can be formed by first spraying a nanoparticle-containing dispersion into aerosol droplets and then heating the aerosol droplets in the presence of a shell precursor to form core-shell particles. By removing either the shell layer or the nanoparticle core of the core-shell particles, monodisperse nanoparticles can be formed.

摘要翻译： 示例性实施方案提供了用于形成单分散颗粒的材料和方法。 在一个实施方案中，单分散颗粒可以通过首先将含纳米颗粒的分散体喷雾到气溶胶液滴中，然后在壳前体的存在下加热气溶胶液滴形成核 - 壳颗粒来形成。 通过去除核 - 壳颗粒的壳层或纳米颗粒芯，可以形成单分散纳米颗粒。

公开(公告)号：US08835877B2

公开(公告)日：2014-09-16

申请号：US13322327

申请日：2010-09-30

申请人： Shuang Luan ,  Lijun Ma ,  Zhe Chen

发明人： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC分类号： B01J19/12

CPC分类号： A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

摘要： Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

摘要翻译： 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg峰值相当的剂量梯度，并优于GammaKnife®放射外科手术。

公开(公告)号：US08835506B2

公开(公告)日：2014-09-16

申请号：US12990334

申请日：2009-06-05

申请人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

发明人： Todd A. Thompson ,  Debra Mackenzie ,  Tudor I. Oprea ,  Larry A. Sklar ,  Bruce S. Edwards ,  Mark Haynes

IPC分类号： A01N33/02 ,  A61K31/165 ,  A61K31/445

CPC分类号： A61K31/437 ,  A61K31/135 ,  A61K31/165 ,  A61K31/445 ,  A61K45/06 ,  A61N5/10

摘要： A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death. While the exact mechanism of cancer cell degradation and death is not completely understood, the treated cancer cells, including refractory prostate cancer cells, give indications of cell death through an autophagic mechanism. Pharmaceutical compositions related to the presently disclosed methods are also disclosed.

摘要翻译： 治疗和/或预防癌症的方法包括在癌细胞中引起增加的细胞内颗粒度的给药剂，至少足以抑制这些细胞增殖的量，优选以足以导致癌细胞死亡的量。 该方法特别涉及难治性癌症，特别是激素难治性前列腺癌。 所鉴定的试剂导致癌细胞中的细胞内颗粒度增加，并且将粘附的癌细胞转化为非贴壁癌细胞，导致癌细胞死亡。 使用本发明，癌细胞在相对低的药物浓度下经历增加的细胞内粒度，同时也抑制细胞增殖。 增加的浓度导致粘附的癌细胞转化为非粘附的癌细胞，然后转移到细胞死亡。 虽然癌细胞降解和死亡的确切机制尚未完全了解，但治疗的癌细胞（包括难治性前列腺癌细胞）通过自噬机制给予细胞死亡的指示。 还公开了与目前公开的方法相关的药物组合物。

公开(公告)号：US08834838B2

公开(公告)日：2014-09-16

申请号：US13854560

申请日：2013-04-01

申请人： STC.UNM

发明人： Jeffrey P. Norenberg ,  Richard S. Larson

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07F9/94 ,  C07F5/00 ,  A61K51/04 ,  A61K49/10

CPC分类号： C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

摘要翻译： 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US08765803B1

公开(公告)日：2014-07-01

申请号：US13404921

申请日：2012-02-24

申请人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aubé ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

发明人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aubé ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

IPC分类号： A01N43/10 ,  A01N43/16

CPC分类号： C07D495/04 ,  A61K31/381 ,  A61K45/06

摘要： This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.

摘要翻译： 本发明涉及化合物及其作为Rab7 GTPase的抑制剂或活化剂的用途，用于治疗或预防Rab 7 GTP酶相关疾病如神经病变，癌症，骨骼和脂质储存代谢疾病的发生。 本发明也适用于Rab7灭活或其蛋白质 - 蛋白质相互作用被调节以促进病原体的细胞内存活的感染性疾病。 所描述的化合物作为核苷酸结合的竞争性抑制剂，因此也可用作靶向其他小GTP酶的支架。 一方面，本发明的治疗方法用于治疗或预防遗传性感觉神经病发作，例如Charcot-Marie-Tooth 2B型疾病。 还提供了相关的药物组合物，测定和药物筛选。

公开(公告)号：US20140161148A1

公开(公告)日：2014-06-12

申请号：US13998782

申请日：2013-12-05

申请人： Marek A. Osinki ,  Gennady A. Smolyakov

发明人： Marek A. Osinki ,  Gennady A. Smolyakov

IPC分类号： H01S5/10

CPC分类号： H01S5/1071 ,  B82Y20/00 ,  H01S5/026 ,  H01S5/06213 ,  H01S5/1032 ,  H01S5/125 ,  H01S5/22 ,  H01S5/34306 ,  H01S5/4006

摘要： The invention provides a semiconductor light-emitting device having a monolithically integrated master laser, such as a distributed-Bragg-reflector (DBR) master laser, and injection-locked ring slave laser with modulated photon lifetime for optical communication beyond 100 GHz.

摘要翻译： 本发明提供了具有单片集成主激光器的半导体发光器件，例如分布式布喇格反射器（DBR）主激光器，以及具有调制光子寿命的注入锁定环形从属激光器，用于超过100GHz的光通信。

公开(公告)号：US20140140505A1

公开(公告)日：2014-05-22

申请号：US14076541

申请日：2013-11-11

申请人： James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

发明人： James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

IPC分类号： H04L9/08

CPC分类号： H04L9/0861 ,  G06F21/73 ,  G09C1/00 ,  H04L9/0866 ,  Y04S40/24 ,  Y10T29/49124

摘要： A system and methods that generates a physical unclonable function (“PUF”) security key for an integrated circuit (“IC”) through use of equivalent resistance variations in the power distribution system (“PDS”) to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

摘要翻译： 通过使用配电系统（“PDS”）中的等效电阻变化，为集成电路（“IC”）生成物理不可克隆功能（“PUF”）安全密钥以减轻安全密钥的漏洞的系统和方法 威胁包括克隆，盗用和未经授权的使用。

公开(公告)号：US08728826B2

公开(公告)日：2014-05-20

申请号：US13597882

申请日：2012-08-29

申请人： Paul A Bentley ,  Michael Davenport

发明人： Paul A Bentley ,  Michael Davenport

IPC分类号： G01N25/18

CPC分类号： G01N33/54326 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22

摘要： The present invention includes a magnetically susceptible polymer component, a method of making the same, and apparatuses and systems for mixing, separating or localizing a magnetically susceptible polymer compound in a reaction. The magnetically susceptible polymer component includes a polymer and a magnetically susceptible particle of a predetermined size, which yields a component having a much-improved magnetic reactivity due to the increase in magnetic material by mass percentage. The apparatuses and systems of the present invention employ controllable magnetic fields distributable in perpendicular directions in order to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel.

摘要翻译： 本发明包括磁敏感聚合物组分，其制备方法以及用于在反应中混合，分离或定位磁敏感性聚合物化合物的装置和系统。 磁敏感聚合物组分包括预定尺寸的聚合物和磁敏感颗粒，其由于磁性材料以质量百分比的增加而产生具有大大提高的磁反应性的组分。 本发明的装置和系统采用可分散在垂直方向上的可控磁场，以便精确地控制反应容器内的任何磁敏组件的取向，位置和相对运动。

公开(公告)号：US08716045B2

公开(公告)日：2014-05-06

申请号：US13783219

申请日：2013-03-01

申请人： STC.UNM

发明人： Stephen D Hersee ,  Xin Wang ,  Xinyu Sun

IPC分类号： H01L21/00 ,  H01L29/41

CPC分类号： H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

摘要： Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

摘要翻译： 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的提供约10nm至约1000微米的均匀长度的III-N族纳米线和/或纳米线阵列，其具有恒定的横截面特征，包括约10-1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。