公开(公告)号：US09903795B2

公开(公告)日：2018-02-27

申请号：US14139158

申请日：2013-12-23

Applicant: Beckman Coulter, Inc.

Inventor： Andreas Van Agthoven

IPC: G01N1/10 ,  G01N1/30

CPC classification number: G01N1/30

Abstract: The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition.

公开(公告)号：US20180038829A1

公开(公告)日：2018-02-08

申请号：US15783388

申请日：2017-10-13

Applicant: Beckman Coulter, Inc.

Inventor： Brian D. Peterson ,  Dale Alan Owens ,  Peter S. Kotowski ,  Sunil S. Deliwala ,  Craig A. Hudson ,  James H. Reyes ,  Clive Cheung ,  Tom Tran ,  Anna X. Lou ,  Jane Luo ,  Jean-Marc Rene Lucien Busnel ,  Chitra K. Ratnayake

IPC: G01N27/447 ,  H01J49/02 ,  G01N30/72 ,  H01J49/16

CPC classification number: G01N27/44743 ,  G01N27/44717 ,  G01N30/7266 ,  H01J49/022 ,  H01J49/165 ,  Y10T307/313

Abstract: Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems.

公开(公告)号：US09816911B2

公开(公告)日：2017-11-14

申请号：US15036712

申请日：2014-11-14

Applicant: Beckman Coulter, Inc.

Inventor： Antao Chen ,  Juan J. Fernandez De Castro ,  Paul K. Church

IPC: G01N21/25 ,  G01N15/14 ,  G01N21/53 ,  G01N21/64 ,  G01N15/00

CPC classification number: G01N15/1436 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G01N2015/0065 ,  G01N2021/6421 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/0637

Abstract: High numerical aperture collection optics for particle analyzers may include an ellipsoidal reflector or an ellipsoidal reflector in combination with a spherical reflector, and may efficiently collect light scattered or emitted by particles in a sample stream and then couple that collected light into a lower numerical aperture portion of the instrument's optical detection system, such as into an optical fiber for example. The reflectors may be integrated with a flow cell through which the sample stream passes, or may be separate components arranged around a flow cell or, in instruments not employing a flow cell, arranged around a sample stream in air. Refractive beam steering optics may allow multiple closely spaced excitation beams to be directed into the sample stream at low angles of incidence. The collection optics and refractive beam steering optics may be employed separately or in combination with each other.

公开(公告)号：US20170297026A1

公开(公告)日：2017-10-19

申请号：US15457877

申请日：2017-03-13

Applicant: Beckman Coulter, Inc. ,  DTIL Ireland Holdings Limited

Inventor： Hiroyuki Onishi ,  Masato Kayahara ,  Hiroshi Suzuki ,  Ryusuke Furuya ,  Naoki Mukaiyama ,  Michael Cooney ,  Marcus O'Neill ,  Sean O'Mahony

IPC: B01L3/00 ,  B29C49/42 ,  G01N35/10 ,  B29C49/04 ,  B29L31/00

Abstract: An embodiment of a reagent container includes a bottle with a pipe to reduce the effects of reagent sloshing. The bottle has an elongated base and an opposed cover connected by side walls and an end wall. A flat platform surrounded by a raised rim lies in the base opposite an opening in the cover. A ribbed pipe frictionally fits within the bottle opening and may attach to the anchor region leaving vent passages around the pipe. The pipe includes an aperture adjacent to the anchor region and oriented toward the end wall so that sloshed fluid has only a small effect on the level of reagent in the pipe during transfers. A modified blow molding process produces the anchor region by extending a pin a predetermined distance into a mold while the molded material is still plastic.

公开(公告)号：US09772274B2

公开(公告)日：2017-09-26

申请号：US14770930

申请日：2014-03-14

Applicant: BECKMAN COULTER, INC.

Inventor： Marshall Donnie Graham ,  William Gerry Graham ,  James P. Clarkin ,  Mark A. Wells ,  Jose M. Cano ,  Carlos Alberto Arboleda ,  Armando J. Sanchez

IPC: G01N21/05 ,  C03B23/047 ,  C03C27/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N21/05 ,  C03B23/047 ,  C03C27/00 ,  G01N15/1434 ,  G01N2015/1006 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2201/02 ,  Y02P40/57

Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.

公开(公告)号：US20170234899A1

公开(公告)日：2017-08-17

申请号：US15587112

申请日：2017-05-04

Applicant: Beckman Coulter, Inc.

Inventor： Michael Eberhardt ,  Martin Mueller ,  Sebastian Wiessner ,  Thomas Moix ,  Guillaume Ding ,  Jurjen Zoethout

IPC: G01N35/00

CPC classification number: G01N35/00584 ,  G01N35/04 ,  G01N2035/0422 ,  G01N2035/0467 ,  G01N2035/0489

Abstract: The invention concerns a laboratory product transport element for a laboratory transport system with an energy receiver and/or energy accumulator to provide drive power, at least one signal receiver to receive control signals, a control unit to generate drive signals as a function of at least one control signal obtained from the at least one signal receiver, movement devices for independent movement of the laboratory product transport element on a transfer path as a function of the drive signals of the control unit, in which the drive devices are driven by the drive power and at least one holder to hold a laboratory product being transported. The invention also concerns a laboratory transport system with at least one laboratory product transport element according to an embodiment of the invention and a transfer path arrangement. The invention also concerns methods for operation of laboratory transport systems according to an embodiment of the invention.

公开(公告)号：US20170136467A1

公开(公告)日：2017-05-18

申请号：US15352473

申请日：2016-11-15

Applicant: Beckman Coulter, Inc.

Inventor： Charles W. Johns ,  Thomas Krafczyk

IPC: B01L9/06 ,  G01N35/00 ,  G01N35/04 ,  G01N35/02

CPC classification number: B01L9/06 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/022 ,  B01L2300/0609 ,  B01L2300/123 ,  G01N35/00732 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/00742 ,  G01N2035/00772 ,  G01N2035/00801 ,  G01N2035/0427 ,  G01N2035/0498

Abstract: A sample tube rack for receiving at least one sample tube comprises an upper part comprising an upper surface, wherein at least one upper opening for receiving the sample tube is provided in the upper surface; an intermediate part comprising an intermediate surface, wherein at least one intermediate opening for receiving the sample tube is provided in the intermediate surface; and a lower part comprising a supporting surface, wherein at least one supporting position for supporting the sample tube is provided in the supporting surface. Therein, the intermediate part is connected to both the upper part and the lower part such that the at least one upper opening is substantially aligned above the at least one intermediate opening and above the at least one supporting position for receiving the at least one sample tube. At least one gripping orifice is provided in a lateral side of the lower part.

公开(公告)号：US20170067927A1

公开(公告)日：2017-03-09

申请号：US15282599

申请日：2016-09-30

Applicant: Beckman Coulter, Inc.

Inventor： Michael Eberhardt ,  Martin Mueller ,  Sebastian Wiessner ,  Thomas Moix ,  Guillaume Ding ,  Jurjen Zoethout

IPC: G01N35/04

CPC classification number: G01N35/00584 ,  G01N35/04 ,  G01N2035/0422 ,  G01N2035/0467 ,  G01N2035/0489

Abstract: The invention concerns a laboratory product transport element for a laboratory transport system with an energy receiver and/or energy accumulator to provide drive power, at least one signal receiver to receive control signals, a control unit to generate drive signals as a function of at least one control signal obtained from the at least one signal receiver, movement devices for independent movement of the laboratory product transport element on a transfer path as a function of the drive signals of the control unit, in which the drive devices are driven by the drive power and at least one holder to hold a laboratory product being transported. The invention also concerns a laboratory transport system with at least one laboratory product transport element according to an embodiment of the invention and a transfer path arrangement. The invention also concerns methods for operation of laboratory transport systems according to an embodiment of the invention.

Abstract translation: 本发明涉及一种用于具有能量接收器和/或能量累加器以提供驱动功率的实验室输送系统的实验室产品传输元件，至少一个用于接收控制信号的信号接收器，控制单元以至少产生作为至少的功能的驱动信号 从至少一个信号接收器获得的一个控制信号，用于根据控制单元的驱动信号在传送路径上独立移动实验室产品传送元件的移动装置，其中驱动装置由驱动力驱动 和至少一个持有人持有要运输的实验室产品。 本发明还涉及具有根据本发明的实施例的至少一个实验室产品传送元件和传送路径布置的实验室传送系统。 本发明还涉及根据本发明实施例的实验室运输系统的操作方法。

公开(公告)号：US09506943B2

公开(公告)日：2016-11-29

申请号：US13671405

申请日：2012-11-07

Applicant: Beckman Coulter, Inc.

Inventor： Martin Müller ,  Charles W. Johns ,  Michael Eberhardt

IPC: G01N35/10 ,  B65G47/28 ,  B01D21/26 ,  B04B7/08 ,  B04B15/00 ,  B25J11/00 ,  B04B9/14 ,  G01N35/00 ,  G01N35/04 ,  G01B11/02 ,  G01B11/08 ,  G01B11/10 ,  G01M1/14 ,  G01N21/27 ,  B04B7/02 ,  B04B13/00 ,  B65D51/24 ,  G01L19/08 ,  B04B11/04 ,  B01L3/00

CPC classification number: G01N35/0099 ,  B01D21/262 ,  B01L3/5021 ,  B04B7/02 ,  B04B7/08 ,  B04B9/14 ,  B04B9/146 ,  B04B11/04 ,  B04B13/00 ,  B04B15/00 ,  B04B2009/143 ,  B04B2011/046 ,  B04B2013/006 ,  B25J11/00 ,  B65D51/24 ,  B65G47/28 ,  G01B11/02 ,  G01B11/08 ,  G01B11/10 ,  G01B11/24 ,  G01F23/00 ,  G01L19/08 ,  G01M1/14 ,  G01N21/27 ,  G01N35/00584 ,  G01N35/00732 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N2035/00495 ,  G01N2035/0405 ,  G01N2035/0462 ,  G01N2035/0491 ,  G01N2035/1025 ,  G01N2035/1032 ,  Y10T29/49826

Abstract: A system is disclosed. The system includes an aliquotter module. The aliquotter module includes a track including: a travel lane; a first loop; and a second loop configured to transport sample carriers with primary sample containers. The aliquotter module can further include a pipettor that can aspirate a first aliquot volume of a sample in a primary sample container located in an aspiration position and dispense the first aliquot volume of the sample in a secondary sample container located in a dispensing position. The aliquotter module can cause the secondary sample container to leave the aliquotter module before the primary sample container.

Abstract translation: 公开了一种系统。 该系统包括等分转换器模块。 等分转换器模块包括轨道，其包括：行驶车道; 第一个循环; 以及第二回路，其构造成用一次样品容器输送样品载体。 等分转换器模块还可以包括移液器，其可将位于吸入位置的初级样品容器中的样品的第一等分试样体积抽吸并将样品的第一等分试样容积分配在位于分配位置的次级样品容器中。 等分转换器模块可以使二次样品容器在初级样品容器之前离开等分转换器模块。

公开(公告)号：US09505563B2

公开(公告)日：2016-11-29

申请号：US14820134

申请日：2015-08-06

Applicant: Beckman Coulter, Inc.

Inventor： Stephen L. Otts

IPC: B65G47/71 ,  B65G47/82 ,  G01N35/04

CPC classification number: B65G47/71 ,  B65G47/82 ,  B65G2201/0261 ,  G01N35/04 ,  G01N2035/0467 ,  G01N2035/0472

Abstract: Embodiments of the invention are directed to a transfer apparatus and a transport system which may be used in automated medical laboratory in-vitro diagnostic systems for handling patient samples. The transfer apparatus an embodiment of the invention comprises a rotatable disc and a lane gate. The transport system according to an embodiment of the invention comprises a transfer path arrangement including at least a first input lane and two output lanes at the transfer apparatus (i.e., the rotatable disc and the lane gate). The rotatable disc and the lane gate are cooperatively structured to function together to move at least one laboratory product transport element between the at least one input lane and the two output lanes of the transport system. The laboratory product transport element transports laboratory products, such as patient samples.

Abstract translation: 本发明的实施例涉及可用于处理患者样品的自动化医学实验室体外诊断系统中的转运装置和运输系统。 传送装置本发明的实施例包括可旋转盘和车道门。 根据本发明的实施例的传输系统包括传输路径布置，其包括在传送设备（即，可旋转盘和车道门）处的至少第一输入通道和两个输出通道。 可旋转盘和车道闸门协同地构造成一起起作用以在运输系统的至少一个输入通道和两个输出通道之间移动至少一个实验室产品运输元件。 实验室产品运输要素运送实验室产品，如病人样品。