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    Gastric resident electronics
    75.
    发明授权
    Gastric resident electronics 有权

    公开(公告)号：US11684315B2

    公开(公告)日：2023-06-27

    申请号：US16202647

    申请日：2018-11-28

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Yong Lin Kong

    IPC分类号： A61B5/00 ,  A61B5/07 ,  A61M31/00

    CPC分类号： A61B5/6885 ,  A61B5/0031 ,  A61B5/073 ,  A61B5/4238 ,  A61B5/6861 ,  A61B5/6871 ,  A61M31/002 ,  A61B2560/0443 ,  A61B2562/0285 ,  A61B2562/162 ,  A61M2205/0216 ,  A61M2205/0272 ,  A61M2205/3523 ,  A61M2210/1053

    摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

    Self-righting systems, methods, and related components
    78.
    发明授权
    Self-righting systems, methods, and related components 有权

    公开(公告)号：US11541016B2

    公开(公告)日：2023-01-03

    申请号：US16899644

    申请日：2020-06-12

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Michael Williams ,  Jacob Wainer

    IPC分类号： A61K9/48 ,  A61M5/142 ,  A61M37/00 ,  A61M5/158 ,  A61M5/145 ,  A61B10/06

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    Self-righting systems, methods, and related components
    79.
    发明授权
    Self-righting systems, methods, and related components 有权

    公开(公告)号：US11541015B2

    公开(公告)日：2023-01-03

    申请号：US16614229

    申请日：2018-05-17

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC分类号： A61K9/48 ,  A61M5/142 ,  A61M37/00 ,  A61M5/158 ,  A61M5/145 ,  A61B10/06

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).