公开(公告)号：US07846706B2

公开(公告)日：2010-12-07

申请号：US12456798

申请日：2009-06-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20100192308A1

公开(公告)日：2010-08-05

申请号：US12667577

申请日：2008-06-16

申请人： Jian Chen ,  Guocheng Du ,  Hejing Yan ,  Jianghua Li

发明人： Jian Chen ,  Guocheng Du ,  Hejing Yan ,  Jianghua Li

IPC分类号： D06L3/14

CPC分类号： D06M16/003 ,  D06L4/40 ,  D06L4/75 ,  D06M2101/06

摘要： A method for scouring and bleaching cotton fabric with composite enzyme preparation in one bath is provided. The method relates to the application of composite alkaline enzyme preparation in scouring and bleaching processes of cotton fabric. The enzyme preparation for scouring and bleaching cotton fabric is compounded from cutinase, alkaline pectase, alkaline xylanase, alkaline cellulose, and carbohydrate oxidase. The method includes: scouring the cotton fabric by adding the composite enzyme preparation, glucose, oxidation bleaching stabilizer RB-3, penetrant JFC, and Triton X-100 in a treating bath at 55-70° C. and pH 8-10, and then bleaching the cotton fabric for 30 min by directly adding tetraacetyl ethylenediamine (TAED) in the scouring bath to activate hydrogen peroxide. After being treated by the method of the present invention, the cotton fabric has high impurity removal ratio, favorable wettability, and high whiteness. The present invention has the advantages of low power consumption, short process flow, and being environment friendly, and may be used to replace conventional chemical treatment process under the condition of concentrated alkali and high temperature.

摘要翻译： 提供了在一个浴中用复合酶制剂冲洗和漂白棉织物的方法。 该方法涉及复合碱性酶制剂在棉织物的漂洗和漂白过程中的应用。 用于冲洗和漂白棉织物的酶制剂由角质酶，碱性果胶酶，碱性木聚糖酶，碱性纤维素和碳水化合物氧化酶组合。 该方法包括：通过在55-70℃和pH8-10的处理浴中加入复合酶制剂，葡萄糖，氧化漂白稳定剂RB-3，渗透剂JFC和Triton X-100来洗涤棉织物，以及 然后通过在洗涤浴中直接加入四乙酰乙二胺（TAED）来活化过氧化氢，使棉织物漂白30分钟。 在通过本发明的方法处理之后，棉织物具有高杂质去除率，良好的润湿性和高白度。 本发明具有功耗低，工艺流程短，环保的优点，可用于在浓碱和高温条件下代替常规化学处理工艺。

公开(公告)号：US07718770B2

公开(公告)日：2010-05-18

申请号：US10183012

申请日：2002-06-26

申请人： Kevin P. Baker ,  Jian Chen ,  Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  James Pan ,  Victoria Smith ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Jian Chen ,  Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  James Pan ,  Victoria Smith ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K14/435 ,  C07H21/00

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A01K2227/105 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/82 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2319/30 ,  C12N9/90 ,  C12N2799/026 ,  C12Q1/6816 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5082 ,  G01N33/5308 ,  G01N33/574 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57484 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2500/10 ,  C12Q2563/131 ,  C12Q2527/137

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20100104584A1

公开(公告)日：2010-04-29

申请号：US12526674

申请日：2008-02-14

申请人： Jian Chen ,  Dan Garza ,  Hao Li ,  Susan C. Stevenson ,  Zhidan Wu

发明人： Jian Chen ,  Dan Garza ,  Hao Li ,  Susan C. Stevenson ,  Zhidan Wu

IPC分类号： A61K39/395 ,  A61P3/10 ,  A61K31/7052 ,  C12Q1/68 ,  G01N33/68 ,  A61P35/00

CPC分类号： G01N33/5079 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/12 ,  C12N2330/31 ,  G01N2800/52

摘要： The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.

摘要翻译： 本发明公开了用于开发治疗，预防或改善与线粒体功能障碍相关的病症的新治疗剂的合适的基因和多肽靶标。 本发明还涉及治疗，预防或改善所述病症及其药物组合物的方法，以及鉴定具有治疗用途以治疗与线粒体功能障碍相关的病症的化合物的方法。

公开(公告)号：US20100067262A1

公开(公告)日：2010-03-18

申请号：US12461593

申请日：2009-08-18

申请人： Jian Chen ,  Koji SONOBE

发明人： Jian Chen ,  Koji SONOBE

IPC分类号： H02M3/335

CPC分类号： H02M3/33592 ,  Y02B70/1433 ,  Y02B70/1475

摘要： A switching power source device for supplying power to a load includes a series resonant circuit, a plurality of main switch elements or main switch element groups for switching a current. path of the series resonant circuit, a transformer for inducing a secondary current from the series resonant circuit, a plurality of synchronous rectification switch elements for rectifying the secondary current, a maximum on width control circuit for ordering a start and a completion of a maximum on width to the synchronous rectification switch element in synchronization with a timing of turning on the main switch elements Or the main switch element groups, and a synchronous control circuit. The circuit controls an on period of the synchronous rectification switch element so as to turn on the synchronous rectification switch element in synchronization with a particular timing, and turn off in synchronization with another timing.

摘要翻译： 用于向负载供电的开关电源装置包括串联谐振电路，用于切换电流的多个主开关元件或主开关元件组。 串联谐振电路的路径，用于从串联谐振电路感应次级电流的变压器，用于整流二次电流的多个同步整流开关元件，用于排序开始和完成最大值的最大宽度控制电路 同步整流开关元件的宽度与打开主开关元件或主开关元件组的定时同步，以及同步控制电路。 电路控制同步整流开关元件的导通周期，以与特定定时同步地接通同步整流开关元件，并与另一定时同步地关断。

公开(公告)号：US07616499B2

公开(公告)日：2009-11-10

申请号：US11617541

申请日：2006-12-28

申请人： Jun Wan ,  Jeffrey W. Lutze ,  Jian Chen ,  Yan Li ,  Alex Mak

发明人： Jun Wan ,  Jeffrey W. Lutze ,  Jian Chen ,  Yan Li ,  Alex Mak

IPC分类号： G11C11/34 ,  G11C16/04 ,  G11C16/06

CPC分类号： G11C16/0483 ,  G11C11/5628 ,  G11C16/3454 ,  G11C16/3459 ,  G11C2211/5621

摘要： Data verification in a memory device using a portion of a data retention margin is provided. A bit count is read from the region to determine whether errors will result in the memory. A read in one or more retention margin portions is performed after the normal program verify sequence and if the number of bits in these regions is more than a pre-set the memory will fail verify status. A method of verifying data in a memory device includes the steps of: defining an retention margin between adjacent data thresholds; programming the memory device with data; determining whether bits are present in the data retention margin; and if the number of bits in the retention margin exceeds a threshold, generating an error.

摘要翻译： 提供了使用部分数据保留余量的存储器件中的数据验证。 从区域读取位计数，以确定错误是否会导致内存。 在正常程序验证序列之后执行在一个或多个保留边缘部分中的读取，并且如果这些区域中的位数大于预设，则存储器将失败验证状态。 验证存储器件中的数据的方法包括以下步骤：定义相邻数据阈值之间的保留余量; 使用数据对存储设备进行编程; 确定位是否存在于数据保留余量中; 并且如果保留余量中的比特数超过阈值，则产生错误。

公开(公告)号：US07569465B2

公开(公告)日：2009-08-04

申请号：US11210218

申请日：2005-08-22

申请人： Jian Chen ,  Masaaki Higashitani

发明人： Jian Chen ,  Masaaki Higashitani

IPC分类号： H01L21/336 ,  H01L21/469

CPC分类号： H01L27/11521 ,  H01L21/7682 ,  H01L23/5222 ,  H01L27/115 ,  H01L2924/0002 ,  H01L2924/00

摘要： A flash EEPROM or other type of memory cell array having adjacent charge storage elements is formed with a gas filled void between them in order to reduce the level of capacitive coupling between storage elements, thus reducing cross-coupling between charge storage elements and resulting errors occurring in the data read from the array.

摘要翻译： 具有相邻电荷存储元件的快闪EEPROM或其它类型的存储单元阵列在它们之间形成有气体填充的空隙，以便降低存储元件之间的电容耦合的电平，从而减少电荷存储元件之间的交叉耦合和产生的错误 在从数组读取的数据中。

公开(公告)号：US20090075468A1

公开(公告)日：2009-03-19

申请号：US12274904

申请日：2008-11-20

申请人： Mihai Buretea ,  Jian Chen ,  Calvin Chow ,  Chunming Niu ,  Yaoling Pan ,  J. Wallace Parce ,  Linda T. Romano ,  David Stumbo

发明人： Mihai Buretea ,  Jian Chen ,  Calvin Chow ,  Chunming Niu ,  Yaoling Pan ,  J. Wallace Parce ,  Linda T. Romano ,  David Stumbo

IPC分类号： H01L21/28

CPC分类号： H01L29/0665 ,  B82Y10/00 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L29/42384 ,  H01L29/66742 ,  H01L29/78681 ,  H01L29/78696 ,  H01L33/06 ,  H01L33/24 ,  H01L51/0048 ,  H01L51/0545 ,  H01L2924/0002 ,  Y10T428/2913 ,  H01L2924/00

摘要： The present invention relates to a system and process for producing a nanowire-material composite. A substrate having nanowires attached to a portion of at least one surface is provided. A material is deposited over the portion to form the nanowire-material composite. The process further optionally includes separating the nanowire-material composite from the substrate to form a freestanding nanowire-material composite. The freestanding nanowire material composite is optionally further processed into a electronic substrate. A variety of electronic substrates can be produced using the methods described herein. For example, a multi-color light-emitting diode can be produced from multiple, stacked layers of nanowire-material composites, each composite layer emitting light at a different wavelength.

摘要翻译： 本发明涉及纳米线材料复合体的制造方法和制造方法。 提供了具有连接到至少一个表面的一部分的纳米线的衬底。 在该部分上沉积材料以形成纳米线材料复合材料。 该方法进一步可选地包括从衬底分离纳米线材料复合物以形成独立的纳米线材料复合材料。 独立的纳米线材料复合材料任选进一步加工成电子基片。 可以使用本文所述的方法来生产各种电子基板。 例如，多个发光二极管可以由多个层叠的纳米线材料复合体制成，每个复合层发射不同波长的光。

公开(公告)号：US07492058B2

公开(公告)日：2009-02-17

申请号：US11676460

申请日：2007-02-19

申请人： Jian Chen

发明人： Jian Chen

IPC分类号： H02J7/00 ,  H02J9/00 ,  H02J3/00 ,  G05D3/12

CPC分类号： H02J9/062 ,  Y10T307/615 ,  Y10T307/707

摘要： In the preferred embodiments, an uninterruptible power supply has multiple UPS modules connected in parallel. Each module has an AC-DC-AC converter and a subcontroller for controlling the operation of the AC-DC-AC converter. A single current sensor senses a total aggregate current flowing from all the modules. Each subcontroller can detect an input voltage, output voltage, and DC bus voltage of each module. Also, each module has unique operating characteristics (e.g., efficiency curve and a responsiveness coefficient K). Operating characteristics data are stored in a memory accessible by the subcontroller. Based on the voltage and current measurements, and the operating characteristics of each module, the subcontrollers perform calculations to determine a DC bus voltage target (unique for each module) that results in each module providing the same output current. Accordingly, only one current sensor is needed, and, consequently, the cost of the UPS device can be reduced.

摘要翻译： 在优选实施例中，不间断电源具有并联连接的多个UPS模块。 每个模块都有AC-DC-AC转换器和用于控制AC-DC-AC转换器工作的子控制器。 单个电流传感器检测从所有模块流出的总聚合电流。 每个子控制器可以检测每个模块的输入电压，输出电压和直流母线电压。 此外，每个模块具有独特的操作特性（例如效率曲线和响应系数K）。 操作特性数据存储在可由子控制器访问的存储器中。 基于电压和电流测量以及每个模块的工作特性，子控制器执行计算以确定每个模块提供相同输出电流的直流总线电压目标（每个模块唯一）。 因此，仅需要一个电流传感器，因此可以减少UPS装置的成本。

公开(公告)号：US07479516B2

公开(公告)日：2009-01-20

申请号：US10850721

申请日：2004-05-21

申请人： Jian Chen ,  Ramasubramaniam Rajagopal

发明人： Jian Chen ,  Ramasubramaniam Rajagopal

IPC分类号： C01B31/02

CPC分类号： B82Y30/00 ,  C08J5/005 ,  C08K7/06 ,  C08K7/24 ,  C08K2201/011 ,  C08L21/00 ,  H01L2224/73253 ,  H01L2924/01021 ,  H01L2924/01046 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/10253 ,  H01L2924/00

摘要： Electrical, thermal and mechanical applications are provided for nanocomposite materials having low percolation thresholds for electrical conductivity, low percolation thresholds for thermal conductivity, or improved mechanical properties.

摘要翻译： 提供电，热和机械应用用于具有低导电渗透阈值，导热性低渗透阈值或改进的机械性能的纳米复合材料。