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71.发明授权
公开(公告)号：US5458140A
公开(公告)日：1995-10-17
申请号：US152442
申请日：1993-11-15
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/681 , A61K41/0047 , A61K49/22 , A61B18/203 , A61B2017/00172 , A61B2017/00765 , A61B2018/00452 , A61B2018/0047 , A61B2562/0295 , A61M2037/0007 , A61M37/0092
摘要： A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from low to high develops a local pressure gradient directed out of the body, thus permitting analytes in the body to traverse the skin and be collected and measured outside the body. The concentration of an analyte in the body is preferably determined by enhancing the permeability of the skin or other biological membrane optionally with a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient out of the body, collecting the analyte, and utilizing the analyte collection data calculating the concentration of the analyte in the body.
摘要翻译： 使用超声波或超声波加上化学增强剂来描述增强皮肤或粘膜对于诊断用途分析物的渗透性的方法。 如果需要，可以通过频率调制，幅度调制，相位调制和/或其组合来调制超声波。 从低到高的频率调制产生了引导出身体的局部压力梯度，从而允许身体中的分析物穿过皮肤并在体外被收集和测量。 体内分析物的浓度优选通过任选地用化学增强剂增强皮肤或其他生物膜的渗透性，任选地以调制的频率，幅度，相位或其组合施加超声来进一步诱导局部压力梯度来确定 收集分析物，并利用分析物收集数据计算体内分析物的浓度。
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72.发明授权Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone 失效用于施用稳定生长激素的聚酐生物可蚀性控释植入物
公开(公告)号：US5122367A
公开(公告)日：1992-06-16
申请号：US332554
申请日：1989-03-31
申请人： Eyal Ron , Mark Chasin , Tom Turek , Robert S. Langer
发明人： Eyal Ron , Mark Chasin , Tom Turek , Robert S. Langer
CPC分类号： A61K38/27 , A61K47/26 , A61K9/2018 , A61K9/2031
摘要： A controlled release device for the administration of biologically active growth hormone proteins or peptide fragments, and method of preparation thereof, wherein biologically active growth hormone is stabilized and release rate modulated by incorporation of a stabilizing compound. The controlled release devices are prepared by mixing a stabilizer, such as sucrose, with a biologically active growth hormone, such as bovine somatotropic hormone, in solution, lyophilizing, then incorporating the dried powder into a surface erodible, biocompatible polymeric matrix, such as a poly(anhydride) or poly(orthoester) matrix.
摘要翻译： 用于施用生物活性生长激素蛋白质或肽片段的控制释放装置及其制备方法，其中生物活性生长激素被稳定并通过引入稳定化合物释放速率。 控制释放装置通过将稳定剂如蔗糖与生物活性生长激素如牛生长激素在溶液中混合来制备，冻干，然后将干燥的粉末掺入表面可侵蚀的生物相容性聚合物基质中，例如 聚（酸酐）或聚（原酸酯）基质。
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公开(公告)号：US4933185A
公开(公告)日：1990-06-12
申请号：US223887
申请日：1988-07-11
CPC分类号： A61K9/1664 , A61K9/1652 , A61K9/5031 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985
摘要： A controlled release system for delivery of a biologically-active substance. In one embodiment, there is a delayed release of a biologically-active substance. In a second embodiment, the delayed release is preceded by an initial release of biologically active substance. In other variations of the system, there are mulitple discrete releases over time or a continuous slow release combined with discrete releases. The delayed exposure is achieved through the design and construction of the system, specifically, formation of ionically-coated microcapsules around the biologically-active substance in conjunction with a microcapsule core-degrading enzyme. Release of active substance takes place in a burst at such a time as the core degrading enzyme has reduced the core to a molecular weight too low to support enough interaction with the cationic skin to maintain its integrity as a skin. In one example, microcapsules are formed of an ionically cross-linked polysaccharide, calcium alginate, which is further ionically coated with a poly-cationic skin of poly-L-lysine. The capsule coating serves a dual purpose: to control diffusion of the biologically-active substance and the core-degrading enzyme and as a substrate for the mechanism by which the biologically-active substance is released after a time delay.
摘要翻译： 用于递送生物活性物质的控制释放系统。 在一个实施方案中，存在生物活性物质的延迟释放。 在第二个实施方案中，延迟释放之前是生物活性物质的初始释放。 在系统的其他变体中，随着时间的推移有多种离散的释放，或者连续的缓慢释放与离散的释放相结合。 延迟曝光是通过系统的设计和构建来实现的，具体地说，在微生物活性物质周围与微胶囊核心降解酶结合形成离子涂覆的微胶囊。 活性物质的释放在核心降解酶已经将核心降低到分子量太低以至于不能支持与阳离子皮肤的足够相互作用以维持其作为皮肤的完整性的时候发生。 在一个实例中，微胶囊由离子交联的多糖，藻酸钙形成，其进一步离子地涂覆有聚-L-赖氨酸的多阳离子皮肤。 胶囊涂层具有双重目的：控制生物活性物质和核心降解酶的扩散，并且作为延迟后释放生物活性物质的机制的底物。
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74.发明授权Bioerodible articles useful as implants and prostheses having predictable degradation rates 失效用作具有可预测降解速率的植入物和假体的生物蚀刻制品
公开(公告)号：US4886870A
公开(公告)日：1989-12-12
申请号：US702168
申请日：1985-02-15
申请人： Patricia D'Amore , Kam W. Leong , Robert S. Langer
发明人： Patricia D'Amore , Kam W. Leong , Robert S. Langer
摘要： A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.
摘要翻译： 提供了可用作植入物和假体的新型系列文章及其制备和使用方法，其利用聚酐聚合物基质作为一般材料类。 这些制品在生物相容性，非炎症性和体内引入后可预测地降解成无毒性残留。 制品可以以任何期望的尺寸和构型形成，并且可以具有特定形状作为血管或皮肤移植物，例如可生物降解的缝线或矫形器具如骨板等。
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公开(公告)号：US09867781B2
公开(公告)日：2018-01-16
申请号：US13400382
申请日：2012-02-20
IPC分类号： A61K9/16 , A61K9/00 , A61K31/573 , A61K45/06 , A61K35/39 , G01N33/50 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , C12N5/071
CPC分类号： A61K9/1641 , A61K9/0019 , A61K31/573 , A61K35/39 , A61K45/06 , A61L27/3804 , A61L27/48 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/622 , A61L2300/64 , C12N5/0676 , C12N2502/1157 , C12N2533/40 , C12N2533/74 , G01N33/5088 , A61K2300/00 , C08L5/04 , C08L5/08
摘要： A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
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76.发明授权Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals 有权涂覆的控释聚合物颗粒作为用于生物药物的高效口服递送载体公开(公告)号：US09492400B2
公开(公告)日：2016-11-15
申请号：US11666908
申请日：2005-11-04
CPC分类号： A61K9/5138 , A61K9/0043 , A61K9/0065 , A61K9/5036 , A61K9/5153 , A61K9/5192 , A61K38/28
摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
摘要翻译： 用于将活性剂递送至患者的组合物。 该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。 聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。 可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。 在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。 组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。
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公开(公告)号：US09333163B2
公开(公告)日：2016-05-10
申请号：US13122654
申请日：2009-10-06
申请人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
发明人： Omid C. Farokhzad , Carolina Salvador-Morales , Weiwei Gao , Liangfang Zhang , Juliana M. Chan , Robert S. Langer
CPC分类号： A61K47/48915 , A61K8/14 , A61K8/86 , A61K31/7088 , A61K39/0005 , A61K39/39 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K49/0065 , A61K49/0067 , A61K49/0093 , A61K2039/55516 , A61K2039/55555 , A61K2039/6093 , A61Q19/00 , B82Y5/00 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/32
摘要： This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
摘要翻译： 本公开涉及以受控马赛克图案显示多个功能化表面结构域的颗粒（例如，纳米颗粒和微粒）。 本公开还提供了简单的方法来产生具有多个功能化表面域的各种颗粒，同时允许使用各种不同的核心结构。 多个功能化区域提供可控的颗粒结合和取向，以及受控和持续的药物释放特征。
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78.发明授权Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production 有权将声音缺陷与可调粘膜植入物匹配的方法和系统，以恢复和增强个性化的人声和声音产生公开(公告)号：US09198568B2
公开(公告)日：2015-12-01
申请号：US13579347
申请日：2011-03-04
CPC分类号： A61B1/2673 , A61L27/26 , A61L27/50 , C08L71/02
摘要： The disclosure relates to methods and systems for making customized treatments to a subject's vocal tissues to provide a desired level of vocal function.
摘要翻译： 本公开涉及用于对受试者的声乐组织进行定制治疗以提供期望水平的声带功能的方法和系统。
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公开(公告)号：US09186640B2
公开(公告)日：2015-11-17
申请号：US11846212
申请日：2007-08-28
申请人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
发明人： Daniel S. Kohane , Yoon Yeo , Peter Given , Robert S. Langer
IPC分类号： A23P1/08 , A23L1/00 , B01J13/10 , A23L1/0522 , A23L1/053 , A23L1/0562 , A23L1/30 , A23L1/48
CPC分类号： A61K9/1075 , A23L2/52 , A23L29/219 , A23L29/25 , A23L29/281 , A23L33/12 , A23P10/30 , A23V2002/00 , A61K9/0053 , A61K9/0095 , A61K31/202 , A61K35/60 , B01J13/10 , A23V2250/187 , A23V2250/1868 , A23V2200/254 , A23V2250/5432 , A23V2250/51 , A23V2200/224 , A23V2250/511 , A23V2250/5022 , A23V2250/54252
摘要： A complex coacervate delivery system is provided which encapsulates lipophilic nutrients such as, for example, fish oils high in omega-3 fatty acids. The complex coacervate delivery system protects the lipophilic nutrient from degradation, e.g., oxidation and hydrolysis, and also reduces or eliminates the unpleasant taste and odor of the lipophilic nutrient. The complex coacervate delivery system upon ingestion is operative to substantially release the lipophilic nutrient in the lower gastrointestinal tract in a pH-controlled manner. The complex coacervate delivery system may be included in a food or beverage product having a pH value within the range of about 1.5 to about 5.0.
摘要翻译： 提供了一种复合凝聚物递送系统，其包封亲脂性营养物质，例如ω-3脂肪酸高的鱼油。 复合凝聚物递送系统保护亲脂性营养物免受降解，例如氧化和水解，并且还减少或消除亲脂性营养物质的令人不快的味道和气味。 摄入后的复合凝聚物递送系统可操作以基于pH控制的方式基本上释放下胃肠道中的亲脂性营养物质。 复合凝聚物递送系统可以包含在pH值在约1.5至约5.0范围内的食品或饮料产品中。
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公开(公告)号：US08912304B2
公开(公告)日：2014-12-16
申请号：US12600596
申请日：2008-05-16
IPC分类号： C08G63/02 , C08G63/668 , A61L27/54 , A61L27/52 , A61L27/58 , A61L27/38 , A61L27/16 , C08G63/21 , C08F283/00
CPC分类号： C08G63/668 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/604 , C08G63/21 , C08L33/02
摘要： The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
摘要翻译： 本发明提供本发明的多元醇基聚合物，材料，药物组合物以及制备和使用本发明的聚合物和材料的方法。 在本发明的某些方面，本发明的聚合物对应于下面描述的聚合物。 示例性的本发明聚合物包括使用与多元羧酸单元（例如柠檬酸，戊二酸或癸二酸）缩合的多元醇单元（例如木糖醇，甘露糖醇，山梨糖醇或麦芽糖醇）制备的那些聚合物。 本发明的聚合物可进一步衍生或修饰。 例如，可以通过向聚合物中加入甲基丙烯酸酯部分使聚合物可光交联。
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