公开(公告)号：US5798223A

公开(公告)日：1998-08-25

申请号：US471496

申请日：1995-06-06

申请人： Yi Li ,  Liang Cao ,  Craig A. Rosen

发明人： Yi Li ,  Liang Cao ,  Craig A. Rosen

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07H21/04 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  C12P21/00 ,  C12N1/15 ,  C12N5/10

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

摘要翻译： 公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。 还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

公开(公告)号：US5786224A

公开(公告)日：1998-07-28

申请号：US496469

申请日：1995-06-29

申请人： Yi Li ,  Carole Young ,  Timothy J. Fischer

发明人： Yi Li ,  Carole Young ,  Timothy J. Fischer

IPC分类号： G01N33/48 ,  G01N33/49 ,  G01N33/50

CPC分类号： G01N33/5094 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/25125 ,  Y10T436/2525

摘要： A lytic reagent composition is provided which selectively stromatolyses red blood cells in a blood sample. In addition, a lytic reagent system is provided which enables the differentiation of at least three subpopulations of leukocytes. A method for using the lytic reagent system is also provided. Still further, the lytic reagent system finds use in the determination of the hemoglobin in the blood. The lytic reagent system utilizes an alkyl sulfate, polyoxyethylene based surfactant and acid with a hypertonic, alkaline, stabilizing reagent. The system and analysis method maintains the cellular morphology of the leukocytes and can be used to analyze normal and abnormal blood samples, fresh and aged blood, human and non-human animal blood samples.

摘要翻译： 提供溶解试剂组合物，其选择性地在血液样品中进行红细胞分解。 此外，提供了一种裂解试剂系统，其能够分化至少三个亚群的白细胞。 还提供了使用溶解试剂系统的方法。 此外，溶解试剂系统用于测定血液中的血红蛋白。 溶解试剂系统使用烷基硫酸盐，聚氧乙烯基表面活性剂和酸与高渗，碱性稳定剂。 系统和分析方法维持白细胞的细胞形态，可用于分析正常和异常的血液样本，新鲜和老化的血液，人和非人动物血液样品。

公开(公告)号：US5763280A

公开(公告)日：1998-06-09

申请号：US786505

申请日：1997-01-21

申请人： Yi Li ,  Carole Young

发明人： Yi Li ,  Carole Young

IPC分类号： G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  G01N33/72

CPC分类号： G01N33/721 ,  G01N33/5094 ,  G01N33/56972 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/105831 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25125

摘要： A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of three leukocyte subpopulations including lymphocytes, monocytes, and granulocytes are described. The cyanide-free lytic reagent composition includes a hemolytic surfactant chosen from quaternary ammonium salts, pyridinium salts, organic phosphate esters, and alkyl sulfonates to lyse erythrocytes and release hemoglobin, and an organic ligand chosen from triazole and its derivatives, tetrazole and its derivatives, alkaline metal salts of oxonic acid, melamine, aniline-2-sulfonic acid, quinaldic acid, 2-amino-1,3,4-thiadiazole, triazine and its derivatives, urazole, DL-pipecolinic acid. isonicotinamide, anthranilonitrile, 6-aza-2-thiothymine, adenine, 3-(2-thienyl)acrylic acid, benzoic acid and alkali metal and ammonium salts of benzoic acid, and pyrazine and its derivatives to form a stable chromogen with hemoglobin. The lytic reagent composition has a pH ranging from about 1 to about 13. The lytic reagent composition is mixed with a blood sample which is prediluted with a suitable blood diluent and the UV absorption of the sample mixture is measured at the predetermined absorption wavelength of the formed chromogen from 510 nm to 560 nm. Counting the numbers of leukocytes and differential counting of three leukocyte subpopulations are accomplished simultaneously on an automated cell counter utilizing DC impedance measurement. Alternatively, the organic ligands can be added to a suitable blood diluent for hemoglobin and leukocyte analysis.

摘要翻译： 描述了一种无氰溶解试剂组合物和用于测量血液样品中总血红蛋白浓度，用于计数白细胞数和用于对包括淋巴细胞，单核细胞和粒细胞在内的三种白细胞亚群进行精确计数的方法。 无氰溶解试剂组合物包括选自季铵盐，吡啶鎓盐，有机磷酸酯和烷基磺酸盐以溶解红细胞并释放血红蛋白的溶血性表面活性剂，以及选自三唑及其衍生物，四唑及其衍生物的有机配体， 硝基酸，三聚氰胺，苯胺-2-磺酸，喹喔啉酸，2-氨基-1,3,4-噻二唑，三嗪及其衍生物的碱金属盐，脲，DL-哌啶酸。 异烟酰胺，邻氨基苯甲腈，6-氮杂-2-硫代胸腺嘧啶，腺嘌呤，3-（2-噻吩基）丙烯酸，苯甲酸和苯甲酸的碱金属和铵盐，吡嗪及其衍生物，与血红蛋白形成稳定的色原体。 溶解试剂组合物的pH为约1至约13.溶液试剂组合物与用合适的血液稀释剂预稀释的血液样品混合，并且在预定的吸收波长下测量样品混合物的UV吸收 形成了510nm至560nm的色原子。 使用直流阻抗测量，在自动细胞计数器上同时实现计数白细胞数量和三个白细胞亚群的差异计数。 或者，可以将有机配体加入合适的血液稀释液中用于血红蛋白和白细胞分析。

公开(公告)号：US09927099B2

公开(公告)日：2018-03-27

申请号：US14003797

申请日：2012-02-24

申请人： Xiliang Wu ,  Yi Li ,  Yi Yang

发明人： Xiliang Wu ,  Yi Li ,  Yi Yang

IPC分类号： F21V13/08 ,  G02B26/00

CPC分类号： F21V13/08 ,  G02B26/008

摘要： An optical-wavelength converting wheel component comprises a motor (1) and an optical-wavelength converting wheel (2). The optical-wavelength converting wheel (2) comprises an optical-wavelength converting material layer (21) and at least one functional layer adjacent to the optical-wavelength converting material layer (21), particularly the optical-wavelength converting wheel (2) further comprises at least one spacing layer (26), which is a thin gap spaced between the location of the optical-wavelength converting material on the optical wavelength converting material layer (21) and the functional layer, arranged between the optical-wavelength converting material layer (21) and the functional layer. Brightening can be realized in low cost by means of adopting a light source comprising the optical-wavelength converting wheel component.

公开(公告)号：US09791132B2

公开(公告)日：2017-10-17

申请号：US14364387

申请日：2012-08-29

申请人： Yi Li ,  Quan Zhang ,  Yi Yang

发明人： Yi Li ,  Quan Zhang ,  Yi Yang

IPC分类号： F21K9/60 ,  F21V13/12 ,  F21V5/00 ,  H01L33/58 ,  F21Y101/00 ,  F21Y105/10 ,  F21Y113/10 ,  F21Y115/10 ,  H01L25/075 ,  H01L33/54

CPC分类号： F21V13/12 ,  F21K9/60 ,  F21V5/007 ,  F21V5/008 ,  F21Y2101/00 ,  F21Y2105/10 ,  F21Y2113/10 ,  F21Y2115/10 ,  H01L25/0753 ,  H01L33/54 ,  H01L33/58 ,  H01L2924/0002 ,  H01L2924/00

摘要： A light source comprises a light emitting diode array (101) and a collimator array (102). The light emitting diode array (101) comprises at least two light emitting diode units (101a, 101b) that emit light of different colors; the collimator array (102) is used for collimating light emitted by the light emitting diode units (101a, 101b) and keep the optical extension of the light emitted by the light emitting diode units (101a, 101b) substantially unchanged. The light source further comprises a dodging device (103) used for dodging light emerging from the collimator array (102). An illuminating device comprises the light source. The light emitting diode units (101a, 101b) and the collimator unit (102a) in the light source and the illuminating device minimize the optical extension of the emergent light, thereby maximizing the luminance.

公开(公告)号：US09704735B2

公开(公告)日：2017-07-11

申请号：US14463285

申请日：2014-08-19

申请人： Manohar S. Konchady ,  Tao Wu ,  Mihir K. Roy ,  Wei-Lun K. Jen ,  Yi Li

发明人： Manohar S. Konchady ,  Tao Wu ,  Mihir K. Roy ,  Wei-Lun K. Jen ,  Yi Li

IPC分类号： H01L21/683 ,  H01L23/538 ,  H01L23/498

CPC分类号： H01L21/6835 ,  H01L23/49816 ,  H01L23/5383 ,  H01L23/5389 ,  H01L2221/68345 ,  H01L2221/68381 ,  H01L2224/04105 ,  H01L2224/12105 ,  H01L2224/1403 ,  H01L2224/16225 ,  H01L2224/16227 ,  H01L2224/18 ,  H01L2224/73267 ,  H01L2924/15192 ,  H01L2924/15311 ,  H01L2924/19106

摘要： A coreless package substrate with dual side solder resist layers is disclosed. The coreless package substrate has a top side and a bottom side opposite of the top side and includes a single build-up structure formed of at least one insulating layer, at least one via, and at least one conductive layer. The coreless package substrate also includes a bottom plurality of contact pads on the bottom side, and a top plurality of contact pads on the top side. A bottom solder resist layer is on the bottom side, and a top solder resist layer is on the top side. The concept of dual side solder resist is extended to packages with interconnect bridge with C4 interconnection pitch over a wide range.

公开(公告)号：US09467667B2

公开(公告)日：2016-10-11

申请号：US13606629

申请日：2012-09-07

申请人： Fei Hu ,  Yi Li ,  Liangliang Cao

发明人： Fei Hu ,  Yi Li ,  Liangliang Cao

IPC分类号： G03B21/20 ,  H04N9/31 ,  G03B33/08 ,  H04N9/73

CPC分类号： H04N9/3111 ,  G03B21/204 ,  G03B21/206 ,  G03B33/08 ,  H04N9/3155 ,  H04N9/3158 ,  H04N9/3194 ,  H04N9/73

摘要： A white balance adjustment method and apparatus for a single DLP projector system is disclosed. The projection system includes a solid state light source device, a sync signal generator, and a controller. The light source device generates an output which is a repeating color sequence of at least two primary color lights. The sync signal generator generates a synchronization signal representing a timing of the color sequence of the output light. The controller calculates drive current values corresponding to each of the two primary colors based on a target white balance and measured color properties of the output light, and supplies a modulated drive current to the light source device. The modulated drive current is synchronized to the sync signal and has the calculated drive current values. As a result, a white light having the target white balance is output.

摘要翻译： 公开了一种用于单个DLP投影仪系统的白平衡调节方法和装置。 投影系统包括固态光源装置，同步信号发生器和控制器。 光源装置产生作为至少两个原色光的重复颜色序列的输出。 同步信号发生器产生表示输出光的颜色序列的定时的同步信号。 控制器基于目标白平衡和输出光的测量颜色属性来计算与两基色中的每一个对应的驱动电流值，并将调制的驱动电流提供给光源装置。 调制驱动电流与同步信号同步并具有计算的驱动电流值。 结果，输出具有目标白平衡的白光。

公开(公告)号：US09355179B2

公开(公告)日：2016-05-31

申请号：US12890097

申请日：2010-09-24

申请人： Yu-Ting Kuo ,  Yi Li ,  Fang Wen ,  Qifa Ke ,  Jian Sun

发明人： Yu-Ting Kuo ,  Yi Li ,  Fang Wen ,  Qifa Ke ,  Jian Sun

IPC分类号： G06F17/30

CPC分类号： G06F17/30867 ,  G06F17/30651 ,  G06F17/30696

摘要： Methods and computer-storage media having computer-executable instructions embodied thereon that facilitate refining query results using visual cues are provided. Query results are determined in response to an indication of a user query. One or more groups of query results are generated from the query results based on categories of query results that share similar features. Visual cues are associated with each of the query result groups. Visual cues, in association with query result groups, are presented to a user. Query results associated with a selected visual cue may be presented to a user. A refined user query may be generated based on a selected visual cue.

摘要翻译： 提供了具有实现在其上的计算机可执行指令的方法和计算机存储介质，其使用视觉提示便于精简查询结果。 响应于用户查询的指示来确定查询结果。 基于共享类似特征的查询结果的类别，从查询结果生成一组或多组查询结果。 视觉线索与每个查询结果组相关联。 与查询结果组相关联的视觉提示被呈现给用户。 与所选择的视觉提示相关联的查询结果可以被呈现给用户。 可以基于所选择的视觉提示来生成精细的用户查询。

公开(公告)号：US20160130319A1

公开(公告)日：2016-05-12

申请号：US14901344

申请日：2014-06-25

申请人： Yi LI ,  GUANGZHOU XIANGXUE PHARMACEUTICAL CO. LTD

发明人： Yi Li

IPC分类号： C07K14/725 ,  A61K38/17 ,  C07K16/28 ,  A61K47/48 ,  A61K49/00

CPC分类号： C07K14/7051 ,  A61K38/00 ,  A61K38/1774 ,  A61K47/6425 ,  A61K49/00 ,  C07K16/2809 ,  C07K2317/76 ,  C07K2319/30

摘要： The present invention provides a high-stability T cell receptor. The T cell receptor has mutations in its hydrophobic core domain causing the enhancement of stability thereof. The present invention additionally provides a preparation method and an application of the T-cell receptor.

摘要翻译： 本发明提供高稳定性T细胞受体。 T细胞受体在其疏水核心结构域中具有突变，导致其稳定性的提高。 本发明另外提供了T细胞受体的制备方法和应用。

公开(公告)号：US09147665B2

公开(公告)日：2015-09-29

申请号：US12887821

申请日：2010-09-22

申请人： Zhengyu Zhu ,  Yi Li ,  FangFang Yang

发明人： Zhengyu Zhu ,  Yi Li ,  FangFang Yang

IPC分类号： H01L23/495 ,  H01L23/00 ,  B81B7/00

CPC分类号： H01L24/32 ,  B81B7/0048 ,  H01L23/49513 ,  H01L24/29 ,  H01L24/48 ,  H01L24/83 ,  H01L24/97 ,  H01L2224/26175 ,  H01L2224/27013 ,  H01L2224/291 ,  H01L2224/29111 ,  H01L2224/29116 ,  H01L2224/29139 ,  H01L2224/29144 ,  H01L2224/2919 ,  H01L2224/29339 ,  H01L2224/32225 ,  H01L2224/48247 ,  H01L2224/83051 ,  H01L2224/8385 ,  H01L2224/92 ,  H01L2224/92247 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01068 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/0133 ,  H01L2924/014 ,  H01L2924/0665 ,  H01L2924/078 ,  H01L2924/07802 ,  H01L2924/0781 ,  H01L2924/10329 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15747 ,  H01L2924/181 ,  H01L2924/19107 ,  H01L2224/83 ,  H01L2224/85 ,  H01L2924/00 ,  H01L2924/3512 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

摘要： Die attach methods used in making semiconductor devices and the semiconductor devices resulting from those methods are described. The methods include providing a leadframe with a die attach pad, using a boundary feature(s) containing a bond wire to define a perimeter on the die attach pad, depositing a conductive material (such as solder) within the perimeter, and then attaching a die containing an integrated circuit device to the die attach pad by using the conductive material. The boundary feature(s) allow an increased thickness of conductive material to be used, resulting in increased bond line thickness and increasing the durability and performance of the resulting semiconductor package. Other embodiments are described.

摘要翻译： 描述用于制造半导体器件的芯片附接方法和由这些方法产生的半导体器件。 所述方法包括使用包含接合线的边界特征来提供具有管芯附接焊盘的引线框架，以在管芯附接焊盘上限定周界，在周边内沉积导电材料（例如焊料），然后附接 通过使用导电材料将包含集成电路器件的裸片封装到管芯附接焊盘。 边界特征允许使用导电材料的增加的厚度，导致增加的结合线厚度并增加所得半导体封装的耐久性和性能。 描述其他实施例。