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891 条记录 (耗时 0.031 秒)

    Process for recovering optical isomers and solvent, process for using solvent by circulation and process for reusing optical isomers in optical resolution
    82.
    发明授权
    Process for recovering optical isomers and solvent, process for using solvent by circulation and process for reusing optical isomers in optical resolution 失效
    回收光学异构体和溶剂的方法，通过循环使用溶剂的方法和在光学拆分中重复使用光学异构体的方法

    公开(公告)号：US5434299A

    公开(公告)日：1995-07-18

    申请号：US156264

    申请日：1993-11-22

    申请人： Masakazu Negawa ,  Fumihiko Shoji

    发明人： Masakazu Negawa ,  Fumihiko Shoji

    IPC分类号： B01D15/00 ,  B01D15/18 ,  B01D15/38 ,  C07B57/00 ,  C07C29/76 ,  C07C33/22 ,  C07C67/48 ,  C07C69/16 ,  B01D15/08

    CPC分类号： B01D15/185 ,  B01D15/3833 ,  C07B57/00

    摘要： A process for recovering and reusing a solvent and optical isomers characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

    摘要翻译： 一种用于回收和再利用溶剂和旋光异构体的方法，其特征在于使用模拟移动填充床，其包括用于洗脱液的入口，用于含有强吸附在包装上的光学异构体的提取物的出口，用于含有光学 异构体混合物和含有在包装上弱吸附的光学异构体的提余液的出口，在包含用于光学拆分的填料的填充床柱中，并且排列在溶剂循环通道中，并且其中入口和出口间歇地和连续地 沿填充床内的液体流动方向移动; 从所得萃取物和/或萃余液中回收溶剂和旋光异构体; 将回收的溶剂返回到溶剂循环通道中; 或者当溶剂未回收时，加热提取物或提余液以使不期望的旋光异构体外消旋化并重复使用含有外消旋变体的所得溶液以用模拟移动床系统分离光学异构体。

    Process for producing optical active 4-hydroxy-2-cyclopentenone
    87.
    发明授权
    Process for producing optical active 4-hydroxy-2-cyclopentenone 失效
    光学活性4-羟基-2-环戊烯酮的制备方法

    公开(公告)号：US5395977A

    公开(公告)日：1995-03-07

    申请号：US31182

    申请日：1993-03-12

    申请人： Fumio Toda ,  Yorihiko Inoue ,  Masayoshi Minai

    发明人： Fumio Toda ,  Yorihiko Inoue ,  Masayoshi Minai

    IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C45/78 ,  C07C45/85 ,  C07C49/707

    CPC分类号： C07C45/78 ,  C07C45/85

    摘要： A process for producing optically active 4-hydroxy-2-cyclopentenone [1] which comprises reacting 4-hydroxy-2-cyclopentenone represented by the formula: ##STR1## with an optically active propargyl alcohol derivative represented by the general formula: ##STR2## wherein R and R.sup.1 each independently represent a halogenated phenyl group, an alkylphenyl group, or an alkyl group which may be substituted with one or more halogen atom(s), and * indicates an asymmetric carbon atom, to form an optically active complex [3] consisting essentially of optically active 4-hydroxy-2-cyclopentenone represented by the formula [1] ##STR3## wherein * indicates an asymmetric carbon atom, and the optically active propargyl alcohol derivative [2], and then decomposing the optically active complex [3].

    摘要翻译： 一种制备光学活性的4-羟基-2-环戊烯酮的方法[1]，其包括使由下式表示的4-羟基-2-环戊烯酮与由下列通式表示的光学活性炔丙醇衍生物反应： 其中R和R 1各自独立地表示卤代苯基，烷基苯基或可以被一个或多个卤素原子取代的烷基，和*表示不对称碳原子以形成光学活性 基本上由式[1]表示的光学活性4-羟基-2-环戊烯酮[3]组成的复合物[3]，其中*表示不对称碳原子和光学活性炔丙醇衍生物[2]，然后 分解光学活性复合物[3]。

    Method of producing optically active 1,3-imidazolidine-4-ones
    88.
    发明授权
    Method of producing optically active 1,3-imidazolidine-4-ones 失效
    光学活性1,3-咪唑烷-4-酮的制备方法

    公开(公告)号：US5386035A

    公开(公告)日：1995-01-31

    申请号：US974422

    申请日：1992-11-12

    申请人： Dieter Seebach ,  Karlheinz Drauz ,  Matthias Kottenhahn ,  Hermann Lotter ,  Michael Schwarm

    发明人： Dieter Seebach ,  Karlheinz Drauz ,  Matthias Kottenhahn ,  Hermann Lotter ,  Michael Schwarm

    IPC分类号： C07B57/00 ,  C07D233/32 ,  C07D233/38 ,  C07D233/30 ,  C07K5/00

    CPC分类号： C07D233/32 ,  C07D233/38

    摘要： 2.2. 1,3-imidazolidine-4-ones having the General Formula: ##STR1## are obtained in a pure form especially by means of precipitation, in which production an optically active acid can be used at 0.5-0.8 eq. for the separation of racemates. The non-desired enantiomer can be racemized in an inert solvent and the cyclization to imidazolidinone can take place by means of the optically active acid, whereupon the separation of racemates takes place directly thereafter. 1,3-imidazolidine-4-ones are valuable educts for the preparation of branched or unbranched, proteinogenic or non-proteinogenic .alpha.-amino acids by means of diastereoselective alkylation and subsequent ring splitting.

    摘要翻译： 2.2。 以纯度的形式，特别是通过沉淀获得具有以下通式的1,3-咪唑烷-4-酮：其中0.5-0.8当量可以使用光学活性的酸。 用于分离外消旋体。 非期望的对映异构体可以在惰性溶剂中进行外消旋化，并且通过光学活性的酸可以进行环化成咪唑啉酮，随后直接进行外消旋体的分离。 1,3-咪唑烷-4-酮是通过非对映选择性烷基化和随后的环分裂制备支链或非支链，蛋白质或非蛋白质的α-氨基酸的有价值的衍生物。

    Selective precipitation of .alpha.-aryl carboxylic acid salts
    90.
    发明授权
    Selective precipitation of .alpha.-aryl carboxylic acid salts 失效
    α-芳基羧酸盐的选择性沉淀

    公开(公告)号：US5380867A

    公开(公告)日：1995-01-10

    申请号：US139245

    申请日：1993-10-19

    申请人： Apurba Bhattacharya ,  John R. Fritch ,  Carl D. Murphy ,  Larry D. Zeagler ,  Carina A. McAdams

    发明人： Apurba Bhattacharya ,  John R. Fritch ,  Carl D. Murphy ,  Larry D. Zeagler ,  Carina A. McAdams

    IPC分类号： C07D333/24 ,  C07B55/00 ,  C07B57/00 ,  C07C51/43 ,  C07C51/487 ,  C07C57/30 ,  C07C227/42 ,  C07C229/26 ,  C07D209/28 ,  C07D233/64 ,  C07D263/56 ,  C07D491/052

    CPC分类号： C07C51/43 ,  C07C51/487

    摘要： A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a molar equivalent of the quantity of one of the enantiomers in the ibuprofen enantiomeric mixture. Upon precipitation of one ibuprofen enantiomer from the mixture, the overall precipitate and reaction mixture can be held for a sufficient period of time at a second temperature to allow the first precipitate to redissolve into the reaction mixture and the other ibuprofen enantiomer to precipitate out of the mixture in the salt form. Optically active ibuprofen is racemized by being heated at 100.degree. C. to 300.degree. C. in the substantial absence of other materials.

    摘要翻译： 提供了通过从含有布洛芬和L-赖氨酸的对映异构体的混合物中选择性沉淀来产生S（+） - 布洛芬或R（ - ） - 布洛芬L-赖氨酸盐的方法。 L-赖氨酸的量不超过布洛芬对映异构体混合物中一种对映异构体的量的约摩尔当量。 当从混合物中沉淀出一种布洛芬对映异构体时，总沉淀物和反应混合物可以在第二个温度下保持足够的时间，以使第一沉淀再溶解到反应混合物中，而另一个布洛芬对映异构体从 盐形式的混合物。 光学活性的布洛芬通过在基本上不存在其它材料的情况下在100℃加热至300℃进行外消旋化。