Process for Preparing a Particle Comprising a Biological Molecule and a Carrier Polymer
    6.
    发明申请
    Process for Preparing a Particle Comprising a Biological Molecule and a Carrier Polymer 有权
    制备包含生物分子和载体聚合物的颗粒的方法

    公开(公告)号:US20090318539A1

    公开(公告)日:2009-12-24

    申请号:US12278855

    申请日:2007-02-08

    IPC分类号: A61K31/713 C12N15/85

    摘要: A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typically supercritical carbon dioxide to separate a particle comprising the biological molecule and the carrier polymer. High loadings of the biological molecule in the particle can be achieved.

    摘要翻译: 制备包含通常为DNA质粒的生物分子的颗粒和通常为聚乳酸(PLA)的载体聚合物的方法,其中生物分子和载体聚合物的有机溶剂溶液在有机溶剂介质中几乎 与生物分子饱和,然后将该溶液与抗溶剂物质(通常为超临界二氧化碳)接触以分离包含生物分子和载体聚合物的颗粒。 可以实现颗粒中生物分子的高负荷。