公开(公告)号：US11672866B2

公开(公告)日：2023-06-13

申请号：US16068235

申请日：2017-01-06

申请人： Paul N. Durfee ,  Charles Jeffrey Brinker ,  Yu-Shen Lin ,  Hon Leong

发明人： Paul N. Durfee ,  Charles Jeffrey Brinker ,  Yu-Shen Lin ,  Hon Leong

IPC分类号： A61K47/54 ,  A61K9/51 ,  A61P35/00 ,  A61K9/16 ,  B82Y5/00 ,  A61K47/69 ,  C12N15/88 ,  A61K47/10 ,  A61K45/06

CPC分类号： A61K47/548 ,  A61K9/16 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5192 ,  A61K47/10 ,  A61K47/6923 ,  A61P35/00 ,  C12N15/88 ,  A61K45/06 ,  A61K2300/00 ,  B82Y5/00

摘要： The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

公开(公告)号：US20180344641A1

公开(公告)日：2018-12-06

申请号：US15757269

申请日：2016-09-02

申请人： C. Jeffrey Brinker ,  Paul N. Durfee ,  Jason Townson ,  Yu-Shen Lin ,  Stanley Shihyao Chou ,  Jacob Erstling

发明人： C. Jeffrey Brinker ,  Paul N. Durfee ,  Jason Townson ,  Yu-Shen Lin ,  Stanley Shihyao Chou ,  Jacob Erstling

IPC分类号： A61K9/127 ,  A61K47/62 ,  A61K47/69 ,  A61P31/14 ,  A61P35/02

CPC分类号： A61K9/1271 ,  A61K9/5146 ,  A61K47/62 ,  A61K47/6923 ,  B82Y5/00 ,  B82Y40/00

摘要： The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.

公开(公告)号：US09001271B2

公开(公告)日：2015-04-07

申请号：US12142796

申请日：2008-06-20

申请人： Chin-Chuan Liang ,  Te-Hao Chang ,  Siou-Shen Lin

发明人： Chin-Chuan Liang ,  Te-Hao Chang ,  Siou-Shen Lin

IPC分类号： H04N7/01 ,  H04N11/20 ,  H04N19/51

CPC分类号： H04N19/577 ,  H04N7/014 ,  H04N19/51 ,  H04N19/513 ,  H04N19/521

摘要： A method for generating an interpolated frame includes: calculating a temporal matching difference corresponding to a target motion vector of a current block by performing a motion estimation on the current block; deriving a spatial relationship result according to the target motion vector and motion vectors corresponding to a plurality of neighboring image blocks; and deriving the interpolated frame according to the target motion vector, the spatial relationship result, and the temporal matching difference.

摘要翻译： 一种生成内插帧的方法包括：通过对当前块执行运动估计来计算与当前块的目标运动矢量相对应的时间匹配差; 根据目标运动矢量和对应于多个相邻图像块的运动矢量导出空间关系结果; 并根据目标运动矢量，空间关系结果和时间匹配差导出内插帧。

公开(公告)号：US08900913B2

公开(公告)日：2014-12-02

申请号：US13588898

申请日：2012-08-17

申请人： Chuan-Jin Shiu ,  Po-Shen Lin ,  Shen-Yuan Mao ,  Cheng-Chi Peng

发明人： Chuan-Jin Shiu ,  Po-Shen Lin ,  Shen-Yuan Mao ,  Cheng-Chi Peng

IPC分类号： H01L33/00 ,  H01L21/00 ,  H01L27/146

CPC分类号： H01L27/14618 ,  H01L2224/13 ,  H01L2933/0025

摘要： An embodiment of the invention provides a method for forming a chip package which includes: providing a substrate having a first surface and a second surface, wherein at least one optoelectronic device is formed in the substrate; forming an insulating layer on the substrate; forming a conducting layer on the insulating layer on the substrate, wherein the conducting layer is electrically connected to the at least one optoelectronic device; and spraying a solution of light shielding material on the second surface of the substrate to form a light shielding layer on the second surface of the substrate.

摘要翻译： 本发明的一个实施例提供了一种用于形成芯片封装的方法，其包括：提供具有第一表面和第二表面的衬底，其中在衬底中形成至少一个光电器件; 在所述基板上形成绝缘层; 在所述基板上的所述绝缘层上形成导电层，其中所述导电层电连接到所述至少一个光电器件; 以及在所述基板的第二表面上喷射遮光材料的溶液，以在所述基板的第二表面上形成遮光层。

公开(公告)号：US08785956B2

公开(公告)日：2014-07-22

申请号：US13560842

申请日：2012-07-27

申请人： Chuan-Jin Shiu ,  Po-Shen Lin ,  Yi-Ming Chang ,  Hui-Ching Yang ,  Chiung-Lin Lai

发明人： Chuan-Jin Shiu ,  Po-Shen Lin ,  Yi-Ming Chang ,  Hui-Ching Yang ,  Chiung-Lin Lai

IPC分类号： H01L33/00 ,  H01L21/00 ,  H01L33/52 ,  H01L27/146 ,  H01L23/00

CPC分类号： H01L27/14623 ,  H01L24/13 ,  H01L27/14618 ,  H01L27/14632 ,  H01L27/14634 ,  H01L27/14636 ,  H01L27/14687 ,  H01L27/1469 ,  H01L33/52 ,  H01L2224/02372 ,  H01L2224/0401 ,  H01L2224/13024 ,  H01L2924/12041 ,  H01L2924/13091 ,  H01L2924/1461 ,  H01L2924/00

摘要： An embodiment of the invention provides a chip package which includes: a substrate having a first surface and a second surface; an optoelectronic device formed in the substrate; a conducting layer disposed on the substrate, wherein the conducting layer is electrically connected to the optoelectronic device; an insulating layer disposed between the substrate and the conducting layer; a first light shielding layer disposed on the second surface of the substrate; and a second light shielding layer disposed on the first light shielding layer and directly contacting with the first light shielding layer, wherein a contact interface is between the first light shielding layer and the second light shielding layer.

摘要翻译： 本发明的实施例提供了一种芯片封装，其包括：具有第一表面和第二表面的基板; 形成在所述基板中的光电子器件; 设置在所述基板上的导电层，其中所述导电层电连接到所述光电子器件; 设置在所述基板和所述导电层之间的绝缘层; 设置在所述基板的第二表面上的第一遮光层; 以及第二遮光层，其设置在所述第一遮光层上并与所述第一遮光层直接接触，其中所述第一遮光层和所述第二遮光层之间的接触界面。

公开(公告)号：US08536671B2

公开(公告)日：2013-09-17

申请号：US13154337

申请日：2011-06-06

申请人： Tsang-Yu Liu ,  Yu-Lin Yen ,  Chuan-Jin Shiu ,  Po-Shen Lin

发明人： Tsang-Yu Liu ,  Yu-Lin Yen ,  Chuan-Jin Shiu ,  Po-Shen Lin

IPC分类号： H01L31/0203

CPC分类号： H01L27/14623 ,  H01L23/481 ,  H01L24/05 ,  H01L24/13 ,  H01L33/44 ,  H01L2224/0401 ,  H01L2224/05027 ,  H01L2224/0557 ,  H01L2224/05572 ,  H01L2224/93 ,  H01L2224/94 ,  H01L2924/0002 ,  H01L2924/01021 ,  H01L2924/12041 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2224/81 ,  H01L2224/11 ,  H01L2224/05552 ,  H01L2924/00

摘要： According to an embodiment of the invention, a chip package is provided, which includes: a substrate having a first surface and a second surface; an optical device between the first surface and the second surface of the substrate; a protection layer formed on the second surface of the substrate, wherein the protection layer has at least an opening; at least a conducting bump formed in the opening of the protection layer and electrically connected to the optical device; and a light shielding layer formed on the protection layer, wherein the light shielding layer is further extended onto a sidewall of the opening of the protection layer.

摘要翻译： 根据本发明的实施例，提供了一种芯片封装，其包括：具有第一表面和第二表面的基板; 在所述基板的所述第一表面和所述第二表面之间的光学装置; 形成在所述基板的第二表面上的保护层，其中所述保护层具有至少一个开口; 至少形成在所述保护层的开口中并电连接到所述光学装置的导电凸起; 以及形成在所述保护层上的遮光层，其中所述遮光层进一步延伸到所述保护层的开口的侧壁上。

公开(公告)号：US08390254B2

公开(公告)日：2013-03-05

申请号：US12750824

申请日：2010-03-31

申请人： Yeh-Shen Lin ,  Yi-Feng Tung ,  Ku-Ching Lu ,  Yun-Chin Lin

发明人： Yeh-Shen Lin ,  Yi-Feng Tung ,  Ku-Ching Lu ,  Yun-Chin Lin

IPC分类号： H02J7/00 ,  H02J9/00

CPC分类号： H02J7/0018 ,  H02J7/0022 ,  Y10T307/50 ,  Y10T307/625

摘要： A charging apparatus for laptop computer with multiple-batteries is used in a first battery unit and a second battery unit. The charging apparatus comprises a micro controller unit; a first charging switch unit electrically connected to the micro controller unit; a second charging switch unit electrically connected to the micro controller unit; and a charging unit electrically connected to the first charging switch unit and the second charging switch unit. The micro controller unit controls the charging unit charging the first battery unit and the second battery unit via controlling the first charging switch unit and the second charging switch unit. The charging apparatus charges multi-batteries simultaneously.

摘要翻译： 在第一电池单元和第二电池单元中使用具有多个电池的膝上型计算机的充电装置。 充电装置包括微控制器单元; 电连接到微控制器单元的第一充电开关单元; 电连接到微控制器单元的第二充电开关单元; 以及与第一充电开关单元和第二充电开关单元电连接的充电单元。 微型控制器单元通过控制第一充电开关单元和第二充电开关单元来控制充电单元对第一电池单元和第二电池单元充电。 充电装置同时对多个电池充电。

公开(公告)号：US20130038638A1

公开(公告)日：2013-02-14

申请号：US13380069

申请日：2011-08-12

申请人： Liang-chan Liao ,  Po-shen Lin ,  Nianmao Wang

发明人： Liang-chan Liao ,  Po-shen Lin ,  Nianmao Wang

IPC分类号： G09G3/36 ,  G09G5/02

CPC分类号： G09G3/3688 ,  G09G2310/0289 ,  G09G2310/0291 ,  G09G2320/0233 ,  G09G2320/0242

摘要： A control circuit includes a power supply, a control IC, a liquid crystal panel, a driving integrated chip arranged between the control IC and the liquid crystal panel, and a number of voltage adjusting sub-circuits. The driving integrated chip includes a plurality of output ports for outputting a plurality of driving voltages respectively. Each voltage adjusting sub-circuit is arranged between the corresponding output port of the driving integrated chip and the liquid crystal panel for adjusting an initial value the voltage outputted from the corresponding output port before the driving voltage is transferred to the liquid crystal panel. With the voltage adjusting sub-circuits, the driving voltages received by the liquid crystal panel have the same value to avoid the color deviation of the images displayed in the liquid crystal panel. This improves the display effect of the liquid crystal panel under without increasing the layout area.

摘要翻译： 控制电路包括电源，控制IC，液晶面板，布置在控制IC和液晶面板之间的驱动集成芯片以及多个电压调整子电路。 驱动集成芯片包括分别输出多个驱动电压的多个输出端口。 每个电压调整子电路布置在驱动集成芯片的相应输出端口和液晶面板之间，用于在将驱动电压传送到液晶面板之前调节从相应输出端口输出的电压的初始值。 利用电压调节子电路，由液晶面板接收的驱动电压具有相同的值，以避免在液晶面板中显示的图像的颜色偏差。 这样可以在不增加布局面积的情况下改善液晶面板的显示效果。

公开(公告)号：US20120105749A1

公开(公告)日：2012-05-03

申请号：US13086373

申请日：2011-04-13

申请人： Szu-Heng Tseng ,  Hong-Shen Lin ,  Jhao-Quei Jhong

发明人： Szu-Heng Tseng ,  Hong-Shen Lin ,  Jhao-Quei Jhong

IPC分类号： G02F1/1335 ,  G09G3/36 ,  G09G5/10

CPC分类号： G03B35/26 ,  G02B27/2242 ,  G02B27/2264 ,  G02B27/26 ,  G02F2001/133601 ,  G09G3/003 ,  G09G3/3233 ,  G09G3/36 ,  G09G2300/023 ,  G09G2300/0861 ,  G09G2300/0866 ,  G09G2310/0218 ,  G09G2310/08 ,  H04N13/337 ,  H04N13/341 ,  H04N13/398

摘要： In a 3D display system, an AMOLED display panel is used for alternatively presenting left-eye images and right-eye images associated with specific images, and an LCD polarizing panel is used for providing the left-eye images and the right-eye images with different polarization angles. When the LCD polarizing panel is in the process of rotating its LCD molecules, corresponding OLED rows of the AMOLED display panel are sequentially turned off so as to display black images, thereby preventing crosstalk and improving display quality.

摘要翻译： 在3D显示系统中，AMOLED显示面板用于替代地呈现与特定图像相关联的左眼图像和右眼图像，并且LCD偏振面板用于向左眼图像和右眼图像提供 不同的偏振角。 当LCD偏振片处于旋转其LCD分子的过程中，AMOLED显示面板的相应的OLED行被依次关闭以显示黑色图像，从而防止串扰并提高显示质量。

公开(公告)号：US07842721B2

公开(公告)日：2010-11-30

申请号：US11844752

申请日：2007-08-24

申请人： An-Shen Lin ,  Yang-Chang Wu ,  Kuo-Hsiung Lee ,  Fang-Rong Chang

发明人： An-Shen Lin ,  Yang-Chang Wu ,  Kuo-Hsiung Lee ,  Fang-Rong Chang

IPC分类号： A01N43/16 ,  C07D311/92

CPC分类号： A61K31/352 ,  C07D311/30 ,  C07D311/78

摘要： A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R1-R12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.

摘要翻译： 提供了具有对癌细胞的细胞毒性作用的药物组合物。 该药物组合物包含具有下式的类黄酮化合物，其中B环是4-氧代 - 环己二烯-2,5-二烯基，R1-R12中的任何一个选自氢基，羟基， C1-C20烷基，C1-C20醚基，C1-C20酯基，羧基，卤素和糖。 类黄酮化合物是从全合成法和半合成法之一的化学方法得到的。