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公开(公告)号:US10272081B2
公开(公告)日:2019-04-30
申请号:US15884044
申请日:2018-01-30
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号: A61K31/05 , A61K31/09 , A61K31/10 , A61K31/12 , C07C39/17 , C07C43/21 , C07C43/23 , C07C49/83 , C07C49/84 , C07C62/32 , C07C62/34 , A61K31/085 , A61K31/095 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/4965 , C07D405/12 , C07C49/835 , C07C43/215 , C07D241/24 , C07D213/81 , C07D249/08 , C07D295/112 , C07D213/75 , C07D295/215 , C07D211/66 , C07C311/18 , C07D213/82 , C07D213/89 , C07D233/64 , C07D401/12 , C07C233/76 , C07D213/38 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C317/22 , C07C217/84 , C07C323/20 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C235/82 , C07C237/08 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496
摘要: Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US10174046B2
公开(公告)日:2019-01-08
申请号:US15676726
申请日:2017-08-14
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
IPC分类号: C07D493/10 , A61K31/416 , C07D213/75 , C07D213/82 , C07D215/227 , C07C275/22 , C07D221/18 , C07D231/54 , C07C215/26 , C07C215/38 , C07C335/10 , C07C233/23 , C07D261/20 , C07D277/24 , C07D277/28 , C07C255/30 , C07D211/58 , C07D213/30 , C07D307/42 , C07D333/16 , C07D231/56 , C07D277/64 , C07C35/21 , C07C35/23 , C07D213/38 , C07D221/16 , C07D307/52 , C07D333/20
摘要: Compounds of formula (II): wherein R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US09937167B2
公开(公告)日:2018-04-10
申请号:US15370973
申请日:2016-12-06
发明人: Lloyd F. Mackenzie , Thomas B. Macrury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号: C07D213/82 , C07C49/83 , A61K31/4965 , A61K31/44 , A61K31/05 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/085 , A61K31/192 , A61K31/09 , A61K31/167 , A61K31/165 , A61K31/277 , A61K31/095 , A61K31/166 , A61K31/4402 , A61K31/4164 , A61K31/4196 , A61K31/495 , A61K31/155 , A61K31/4406 , A61K31/4465 , A61K31/10 , A61K31/443 , A61K31/444 , A61K31/4439 , A61K31/496
CPC分类号: A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12
摘要: Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US20180086691A9
公开(公告)日:2018-03-29
申请号:US15411863
申请日:2017-01-20
IPC分类号: C07C209/30
CPC分类号: C07C209/30 , C07B2200/07 , C07C213/00 , C07C249/12 , C07C2101/14 , C07C2102/02 , C07C2601/14 , C07C2602/02 , C07C2602/24 , C07D307/77 , C07D317/70 , C07D317/72 , C07J1/0011 , C07J1/0022 , C07J13/007 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/0026 , C07J73/003 , C07J73/005 , C07C215/42
摘要: This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
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公开(公告)号:US20180360828A9
公开(公告)日:2018-12-20
申请号:US15884044
申请日:2018-01-30
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号: A61K31/4965 , A61K31/496 , A61K31/444 , A61K31/443 , A61K31/10 , A61K31/4465 , A61K31/4406 , A61K31/155 , A61K31/495 , A61K31/4196 , A61K31/4164 , A61K31/4402 , A61K31/166 , A61K31/095 , A61K31/277 , A61K31/165 , A61K31/167 , A61K31/09 , A61K31/192 , A61K31/05 , A61K31/085 , A61K31/135 , A61K31/122 , A61K31/12 , A61K31/4439
CPC分类号: A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12
摘要: Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US20180161324A1
公开(公告)日:2018-06-14
申请号:US15884044
申请日:2018-01-30
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew , Vladimir Khlebnikov , Rudong Shan
IPC分类号: A61K31/4965 , A61K31/496 , A61K31/444 , A61K31/443 , A61K31/10 , A61K31/4465 , A61K31/4406 , A61K31/155 , A61K31/495 , A61K31/4196 , A61K31/4164 , A61K31/4402 , A61K31/166 , A61K31/095 , A61K31/277 , A61K31/165 , A61K31/167 , A61K31/09 , A61K31/192 , A61K31/05 , A61K31/085 , A61K31/135 , A61K31/122 , A61K31/12 , A61K31/4439
CPC分类号: A61K31/4965 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/095 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/4164 , A61K31/4196 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4465 , A61K31/495 , A61K31/496 , C07B2200/07 , C07C39/17 , C07C43/21 , C07C43/215 , C07C43/23 , C07C49/83 , C07C49/835 , C07C49/84 , C07C62/32 , C07C62/34 , C07C217/84 , C07C225/20 , C07C233/26 , C07C233/28 , C07C233/31 , C07C233/32 , C07C233/60 , C07C233/76 , C07C235/82 , C07C237/08 , C07C255/47 , C07C275/26 , C07C275/64 , C07C279/16 , C07C311/07 , C07C311/17 , C07C311/18 , C07C317/22 , C07C323/20 , C07C2602/28 , C07D211/66 , C07D213/38 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/89 , C07D233/64 , C07D241/24 , C07D249/08 , C07D295/112 , C07D295/215 , C07D401/12 , C07D405/12
摘要: Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US20180155359A9
公开(公告)日:2018-06-07
申请号:US15676726
申请日:2017-08-14
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
IPC分类号: C07D493/10 , C07D333/20 , C07D307/52 , C07C35/21 , C07D307/42 , C07D277/64 , C07D277/28 , C07D261/20 , C07D231/56 , C07D231/54 , C07D221/16 , C07D215/227 , C07D213/82 , C07D213/75 , C07D213/38 , C07D211/58 , C07C335/10 , C07C275/22 , C07C255/30 , C07C233/23 , C07C215/38 , C07C35/23 , C07C2602/24 , C07C2601/14
CPC分类号: C07D493/10 , A61K31/416 , C07C35/21 , C07C35/23 , C07C215/26 , C07C215/38 , C07C233/23 , C07C255/30 , C07C275/22 , C07C335/10 , C07C2601/14 , C07C2602/24 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/75 , C07D213/82 , C07D215/227 , C07D221/16 , C07D221/18 , C07D231/54 , C07D231/56 , C07D261/20 , C07D277/24 , C07D277/28 , C07D277/64 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20
摘要: Compounds of formula (II): wherein R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US20170362250A1
公开(公告)日:2017-12-21
申请号:US15676726
申请日:2017-08-14
发明人: Lloyd F. Mackenzie , Thomas B. MacRury , Curtis Harwig , David Bogucki , Jeffery R. Raymond , Jeremy D. Pettigrew
IPC分类号: C07D493/10 , C07D307/52 , C07C35/21 , C07D307/42 , C07D277/64 , C07D277/28 , C07D261/20 , C07D231/56 , C07D231/54 , C07D221/16 , C07D215/227 , C07D213/82 , C07D213/75 , C07D213/38 , C07D211/58 , C07C335/10 , C07C275/22 , C07C255/30 , C07C233/23 , C07C215/38 , C07C35/23 , C07D333/20 , C07C2602/24 , C07C2601/14
CPC分类号: C07D493/10 , A61K31/416 , C07C35/21 , C07C35/23 , C07C215/26 , C07C215/38 , C07C233/23 , C07C255/30 , C07C275/22 , C07C335/10 , C07C2601/14 , C07C2602/24 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/75 , C07D213/82 , C07D215/227 , C07D221/16 , C07D221/18 , C07D231/54 , C07D231/56 , C07D261/20 , C07D277/24 , C07D277/28 , C07D277/64 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/20
摘要: Compounds of formula (II): wherein R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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公开(公告)号:US20170204048A1
公开(公告)日:2017-07-20
申请号:US15411863
申请日:2017-01-20
IPC分类号: C07C209/30
CPC分类号: C07C209/30 , C07B2200/07 , C07C213/00 , C07C249/12 , C07C2101/14 , C07C2102/02 , C07C2601/14 , C07C2602/02 , C07C2602/24 , C07D307/77 , C07D317/70 , C07D317/72 , C07J1/0011 , C07J1/0022 , C07J13/007 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/0026 , C07J73/003 , C07J73/005 , C07C215/42
摘要: This invention is directed to methods of preparing AQX-1125 having the formula: This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
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公开(公告)号:US10100056B2
公开(公告)日:2018-10-16
申请号:US14772737
申请日:2014-02-27
IPC分类号: C07D473/34 , C07D207/335 , C07D207/06 , C07D213/38 , C07D231/12 , C07D249/08 , C07D233/60 , C07D209/08 , C07D317/46 , C07D295/096 , C07D213/64 , C07D239/34 , C07D241/18 , C07C279/08 , C07C215/42 , C07C233/23 , C07C311/04 , C07C225/10 , C07C233/74 , C07C255/31 , C07C275/24
摘要: Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
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