公开(公告)号：US07217722B2

公开(公告)日：2007-05-15

申请号：US10181943

申请日：2001-01-02

申请人： Atsuya Takami ,  Hiroshi Iijima ,  Masayuki Iwakubo ,  Yuji Okada

发明人： Atsuya Takami ,  Hiroshi Iijima ,  Masayuki Iwakubo ,  Yuji Okada

IPC分类号： C07D213/75 ,  A61K31/47

CPC分类号： C07D473/34 ,  C07C275/42 ,  C07D209/48 ,  C07D213/75 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12

摘要： An objective of the present invention is to provide compounds having Rho kinase inhibitory activity. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: Het—X—Z  (I) wherein Het represents a monocyclic or bicyclic heterocyclic group containing at least one nitrogen atom, for example, pyridyl or phthalimide; X represents group (i) —NH—C(═O)—NH—Q1-, group (ii) —NH—C(═O)—Q2-, wherein Q1 and Q2 represent a bond, alkylene, or alkenylene, or the like; and Z represents hydrogen, halogen, a monocyclic, bicyclic, or tricyclic carbocyclic group, a heterocyclic group or the like, for example, optionally substituted phenyl.

摘要翻译： 本发明的目的是提供具有Rho激酶抑制活性的化合物。 根据本发明的化合物是由式（I）表示的化合物或其药学上可接受的盐或溶剂合物：<？在线配方描述=“在线配方”末端=“铅”→Het-XZ（I 其中Het表示含有至少一个氮原子的单环或双环杂环基，例如吡啶基或邻苯二甲酰亚胺;其中Het表示含有至少一个氮原子的单环或双环杂环基; X表示基团（i）-NH-C（-O）-NH-Q1-，基团（ⅱ）-NH-C（-O）-Q2-，其中Q1和Q2表示键，亚烷基或亚烯基，或 类似; Z表示氢，卤素，单环，双环或三环碳环基，杂环基等，例如任选取代的苯基。

公开(公告)号：US07615564B2

公开(公告)日：2009-11-10

申请号：US10527643

申请日：2003-09-12

申请人： Masayuki Iwakubo ,  Yuji Okada

发明人： Masayuki Iwakubo ,  Yuji Okada

IPC分类号： C07D403/02 ,  A61K31/4709

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14

摘要： An objective of the present invention is to provide compounds having Rho kinase inhibitory activity and useful for the treatment of diseases mediated by Rho kinase. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein Q represents phenyl, pyridyl, pyrrolyl, thienyl, or furyl; these groups are optionally substituted by one or two halogens or alkyl, nitro, or amino groups; and p is 2 or 3.

摘要翻译： 本发明的目的是提供具有Rho激酶抑制活性并可用于治疗由Rho激酶介导的疾病的化合物。 根据本发明的化合物是由式（I）表示的化合物或其药学上可接受的盐或溶剂化物：其中Q表示苯基，吡啶基，吡咯基，噻吩基或呋喃基; 这些基团任选被一个或两个卤素或烷基，硝基或氨基取代; p为2或3。

公开(公告)号：US20060167043A1

公开(公告)日：2006-07-27

申请号：US10527643

申请日：2003-09-12

申请人： Masayuki Iwakubo ,  Yuji Okada

发明人： Masayuki Iwakubo ,  Yuji Okada

IPC分类号： A61K31/4709 ,  C07D401/02 ,  C07D403/02

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14

摘要： An objective of the present invention is to provide compounds having Rho kinase inhibitory activity and useful for the treatment of diseases mediated by Rho kinase. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein Q represents phenyl, pyridyl, pyrrolyl, thienyl, or furyl; these groups are optionally substituted by one or two halogens or alkyl, nitro, or amino groups; and p is 2 or 3.

公开(公告)号：US5999766A

公开(公告)日：1999-12-07

申请号：US35000

申请日：1998-03-05

申请人： Kenji Hisatomi ,  Hideyuki Kuwano ,  Naoki Takahashi ,  Takehito Yamaguchi ,  Yuji Okada ,  Kazuyuki Murata

发明人： Kenji Hisatomi ,  Hideyuki Kuwano ,  Naoki Takahashi ,  Takehito Yamaguchi ,  Yuji Okada ,  Kazuyuki Murata

IPC分类号： H04N1/32 ,  H04N1/44 ,  G03G15/00

CPC分类号： H04N1/32561 ,  H04N1/00912 ,  H04N1/4413 ,  H04N1/4426 ,  H04N2201/0081 ,  H04N2201/0082 ,  H04N2201/0087

摘要： An image processing apparatus for storing and reading out image data. An authorization code inputting element reads in an authorization code from an authorization medium on which a particular authorization code is recorded and a user identification inputting element inputs user identification information including the individual user authorization number issued at the time of the user being registered. A user control element controls the users by the authorization code and the user identification information, and a function-limiting element limits the scope of functions that can be used by the user in case the user can not be identified by the inputted authorization code or the inputted user identification information. Thus, the storing of image data by an unidentified user can be blocked, and the confidentiality of stored imaged data can be secured.

摘要翻译： 一种用于存储和读出图像数据的图像处理装置。 授权代码输入单元从记录有特定授权码的授权介质读入授权代码，用户识别输入单元输入包含用户注册时发行的个人用户授权号的用户识别信息。 用户控制元件通过授权代码和用户识别信息来控制用户，并且功能限制元件在用户不能被输入的授权码或者输入的授权码识别的情况下限制用户可以使用的功能的范围 输入用户识别信息。 因此，可以阻止由未识别的用户存储图像数据，并且可以确保存储的成像数据的机密性。

公开(公告)号：US5850868A

公开(公告)日：1998-12-22

申请号：US609673

申请日：1996-03-01

申请人： Yuji Okada ,  Masamichi Okada ,  Tsutomu Ishikawa ,  Takumi Yamamoto ,  Tatsuhiko Sawamura ,  Norio Hayashi ,  Takayuki Ito

发明人： Yuji Okada ,  Masamichi Okada ,  Tsutomu Ishikawa ,  Takumi Yamamoto ,  Tatsuhiko Sawamura ,  Norio Hayashi ,  Takayuki Ito

IPC分类号： B22D18/02 ,  B22C9/10 ,  B22D17/22 ,  B22D29/00 ,  B22D30/00

CPC分类号： B22D29/001 ,  B22D30/00

摘要： A casting method is disclosed in which a resin core is fabricated by using a resin which maintains a mechanical strength satisfying a shape accuracy required for a cast product until solidification of molten metal in contact with the core and is softened when heated beyond the core temperature at which the molten metal in contact with the core was solidified. The removal of the resin core from the cast product after the cast product containing the core from a die, includes a step of forcedly cooling the cast product containing the core down to a predetermined temperature at which the resin core can be removed from the cast product without being broken apart by pulling one of its ends, and a step of withdrawing the core at the predetermined temperature from the cast product having been forcedly cooled down. It is thus possible to cool the core down to a predetermined temperature suited for the withdrawal and preclude the inconvenience that the core being pulled is broken apart.

摘要翻译： 公开了一种铸造方法，其中通过使用树脂来制造树脂芯，所述树脂保持机械强度满足铸造产品所需的形状精度，直到熔融金属与芯接触固化，并且当加热超过芯温度时软化 其中与芯接触的熔融金属固化。 在从模具中含有芯的铸造产品之后，从铸造产品中去除树脂芯包括将包含芯的铸造产品强制冷却到可以从铸造产品中去除树脂芯的预定温度的步骤 通过拉动其一个端部而不会分开，并且在预定温度下从已被强制冷却的铸造产品中取出芯的步骤。 因此，可以将芯冷却到适合于退出的预定温度，并且排除被拉动的芯分离的不便。

公开(公告)号：US20140114021A1

公开(公告)日：2014-04-24

申请号：US14008611

申请日：2012-03-27

申请人： Yuji Okada ,  Yoshito Kuroda

发明人： Yuji Okada ,  Yoshito Kuroda

IPC分类号： C07F7/21 ,  C08K3/20 ,  C09D183/06 ,  C08F130/08

CPC分类号： C07F7/21 ,  C08F130/08 ,  C08F299/08 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/44 ,  C08G77/50 ,  C08K3/20 ,  C08K5/56 ,  C08K2201/008 ,  C08L83/00 ,  C08L83/04 ,  C08L83/14 ,  C09D11/00 ,  C09D11/101 ,  C09D183/06 ,  C09D183/14 ,  C09J183/14 ,  H01L33/56

摘要： The present invention provides organopolysiloxane comprising one or more unsaturated bond-containing group(s) in one molecule and having constitutional units F1, M1, and T in any combination of (i) F1 and M1, (ii) F1 and T, and (iii) F1, M1, and T: wherein R1 represents any selected from the group consisting of a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted cycloalkyl group having 3 to 10 carbon atoms, a substituted or unsubstituted aryl group, and a substituted or unsubstituted aralkyl group; R2 represents an unsaturated bond-containing group having 2 to 10 carbon atoms; X represents a divalent hydrocarbon group having 2 to 10 carbon atoms; Y represents a divalent hydrocarbon group having 2 to 10 carbon atoms; and a, b, and c each independently represent an integer of 1 or larger, wherein F1 represents a unit constituting cyclic organopolysiloxane.

摘要翻译： 本发明提供了在一个分子中包含一个或多个含不饱和键的基团并且具有（i）F1和M1的任何组合的结构单元F1，M1和T的有机聚硅氧烷，（ii）F1和T以及（ iii）F1，M1和T：其中R1表示选自取代或未取代的碳原子数1〜10的烷基，取代或未取代的碳原子数3〜10的环烷基，取代或未取代的芳基 基团和取代或未取代的芳烷基; R2表示含有2〜10个碳原子的不饱和键基团; X表示碳原子数2〜10的二价烃基， Y表示碳原子数2〜10的二价烃基; a，b，c各自独立地表示1以上的整数，其中，F1表示构成环状有机聚硅氧烷的单元。

公开(公告)号：US08445847B2

公开(公告)日：2013-05-21

申请号：US12593541

申请日：2008-03-25

申请人： Yuichi Furukawa ,  Shingo Nakamura ,  Yuji Okada ,  Fumio Kawahara

发明人： Yuichi Furukawa ,  Shingo Nakamura ,  Yuji Okada ,  Fumio Kawahara

IPC分类号： G01J5/00

CPC分类号： G01J5/0003 ,  G01J5/004 ,  G01J5/0044 ,  G01J5/02 ,  G01J5/026 ,  G01J5/04 ,  G01J5/043 ,  G01J5/08 ,  G01J5/0803 ,  G01J5/0846 ,  G01J5/0859 ,  G01J5/12 ,  G01J5/522 ,  G01J2005/0077 ,  G01J2005/0081

摘要： A technique for an infrared radiation thermometer used for thermography detects measurement abnormality of the infrared radiation thermometer and estimates the causes of the measurement abnormality such as contamination of an objective lens and a malfunction in a mechanism section of the infrared radiation thermometer. The measurement abnormality detector has a dummy lens 21 placed in the periphery of the objective lens 11 of the thermometer 10 so as to be at a position and in an attitude that are more susceptible to contamination than the objective lens 11, a laser displacement meter 22 for projecting light to the dummy lens 21 at each predetermined time or at a predetermined timing, receiving the light reflected by the dummy lens 21, and measuring the quantity of the received light, and determination means 50 for calculating the attenuation rate of the projected light on the basis of the quantity of the received light measured by the laser displacement meter 22, estimating the degree of contamination of the dummy lens 21 on the basis of the calculated attenuation rate, and judging, on the basis of the degree of contamination of the dummy lens 21, the necessity of warning for contamination of the objective lens 11 and measurement abnormality of the thermometer 10.

摘要翻译： 用于热成像的红外辐射温度计的技术检测红外线辐射温度计的测量异常，并估计红外辐射温度计的机构部分中的物镜的污染和误差等测量异常的原因。 测量异常检测器具有放置在温度计10的物镜周边的虚拟透镜21，以便处于比物镜11更容易被污染的位置和姿态，激光位移计22 用于在每个预定时间或在预定定时将光投射到虚拟透镜21，接收由虚设透镜21反射的光并测量接收光的量;以及确定装置50，用于计算投影光的衰减率 基于由激光位移计22测量的接收光的量，基于计算出的衰减率来估计虚设透镜21的污染程度，并且基于所计算的衰减率的污染程度， 假透镜21，必须警告物镜11的污染和温度计10的测量异常。

公开(公告)号：US20090171053A1

公开(公告)日：2009-07-02

申请号：US12226224

申请日：2007-04-16

申请人： Yuji Okada ,  Kenji Ebara

发明人： Yuji Okada ,  Kenji Ebara

IPC分类号： C08F112/08 ,  C07C7/00 ,  C07C15/02

CPC分类号： C07B63/00 ,  C07C7/1485 ,  C07C7/14891 ,  C08F6/00 ,  C08F212/12 ,  C07C15/44 ,  C08L25/16 ,  C08F212/08

摘要： An object of the present invention is to provide highly pure α-methylstyrene by efficiently removing polar substances present in the α-methylstyrene. The present invention discloses a method for purifying α-methylstyrene by reacting polar substances contained in the α-methylstyrene in the presence of a basic substance, and separating a reaction product of the polar substance and the α-methylstyrene.

摘要翻译： 本发明的目的是通过有效去除α-甲基苯乙烯中存在的极性物质来提供高纯度的α-甲基苯乙烯。 本发明公开了一种通过在碱性物质的存在下使α-甲基苯乙烯中所含的极性物质反应并分离极性物质与α-甲基苯乙烯的反应产物来提纯α-甲基苯乙烯的方法。

公开(公告)号：US07550096B2

公开(公告)日：2009-06-23

申请号：US11965965

申请日：2007-12-28

申请人： Kensho Sakano ,  Kazuhiko Sakai ,  Yuji Okada ,  Toshihiko Umezu

发明人： Kensho Sakano ,  Kazuhiko Sakai ,  Yuji Okada ,  Toshihiko Umezu

IPC分类号： C09K11/00

CPC分类号： C08L63/00 ,  B29C67/08 ,  C09K11/02 ,  C09K11/7774 ,  H01L24/45 ,  H01L24/97 ,  H01L33/486 ,  H01L33/502 ,  H01L33/504 ,  H01L33/508 ,  H01L33/54 ,  H01L2224/32245 ,  H01L2224/45015 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2224/48465 ,  H01L2224/49107 ,  H01L2224/73265 ,  H01L2224/8592 ,  H01L2224/97 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01012 ,  H01L2924/0102 ,  H01L2924/01021 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/0103 ,  H01L2924/01032 ,  H01L2924/01033 ,  H01L2924/01038 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01051 ,  H01L2924/01052 ,  H01L2924/01056 ,  H01L2924/01057 ,  H01L2924/01058 ,  H01L2924/0106 ,  H01L2924/01063 ,  H01L2924/01065 ,  H01L2924/01066 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01084 ,  H01L2924/01087 ,  H01L2924/10329 ,  H01L2924/12036 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/181 ,  H01L2924/3025 ,  H01L2924/351 ,  H01L2924/00014 ,  H01L2224/85 ,  H01L2224/83 ,  H01L2924/00 ,  H01L2924/20753 ,  H01L2924/00012

摘要： A method for producing a fluorescent material involving firing a mixture of a stock material and a flux. The method may involve a first firing process involving firing the mixture of the stock material and the flux in a weakly reducing atmosphere, followed by firing the resulting material in a second reducing atmosphere that is more reducing than the first weakly reducing atmosphere. The flux may include a liquid.

摘要翻译： 一种生产含有原料和助熔剂混合物的荧光材料的方法。 该方法可以涉及第一次焙烧工艺，包括在弱还原气氛中烧制原料和助熔剂的混合物，然后在比第一弱还原气氛还原的第二还原气氛中煅烧所得材料。 助焊剂可以包括液体。

公开(公告)号：US20090026480A1

公开(公告)日：2009-01-29

申请号：US12179327

申请日：2008-07-24

申请人： Masaki HAYASHI ,  Yuji Okada ,  Koji Kuroda

发明人： Masaki HAYASHI ,  Yuji Okada ,  Koji Kuroda

IPC分类号： H01L33/00 ,  H01L21/00

CPC分类号： H01L33/46 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L24/97 ,  H01L25/0753 ,  H01L33/62 ,  H01L2224/45015 ,  H01L2224/45124 ,  H01L2224/45139 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/4516 ,  H01L2224/45184 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/48139 ,  H01L2224/48247 ,  H01L2224/48465 ,  H01L2224/48599 ,  H01L2224/48699 ,  H01L2224/49113 ,  H01L2224/49175 ,  H01L2224/8592 ,  H01L2224/97 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01012 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01019 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/0103 ,  H01L2924/01032 ,  H01L2924/01033 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/10329 ,  H01L2924/12035 ,  H01L2924/12036 ,  H01L2924/12041 ,  H01L2924/15787 ,  H01L2924/16195 ,  H01L2924/181 ,  H01L2224/85 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012 ,  H01L2924/20752 ,  H01L2924/00015

摘要： Provided is a light emitting device with high extraction efficiency, in which absorption of light by a conductive wire is prevented effectively. The light emitting device includes a conductive wire electrically connecting an electrode of a light emitting element and an electrically conductive member. The surface of the bonding portion of the conductive wire between the conductive wire and at least one of the electrode of the light emitting element and the electrically conductive member is covered with a metal film. The reflectivity of the metal film is higher than that of the conductive wire at the emission peak wavelength of the light emitting element.

摘要翻译： 提供了一种具有高提取效率的发光器件，其中有效地防止了由导线吸收光。 发光器件包括将发光元件的电极和导电构件电连接的导线。 在导线与发光元件的电极和导电部件的至少一个之间的导线的接合部分的表面被金属膜覆盖。 在发光元件的发射峰值波长处，金属膜的反射率高于导线的反射率。