公开(公告)号：US20080233201A1

公开(公告)日：2008-09-25

申请号：US10591131

申请日：2005-03-03

申请人： Audrey Royere ,  Didier Bazile ,  Jerome Bibette

发明人： Audrey Royere ,  Didier Bazile ,  Jerome Bibette

IPC分类号： A61K9/14 ,  A61K38/00 ,  A61K31/70

CPC分类号： B01J13/12 ,  B01J13/04

摘要： The invention relates to a method for preparing monodispersed biodegradable microspheres consisting in a) preparing an emulsion containing at least one polymeric phase and at least one aqueous phase at a viscosity ratio between the dispersed polymeric phase and the aqueous phase ranging from 0.12 to 10, b) exposing the thus obtained emulsion to a controlled laminar shear strength, c) removing a solvent from the polymeric phase and in d) isolating the thus obtained microspheres. The use of the prepared microspheres is also disclosed.

摘要翻译： 本发明涉及一种制备单分散生物可降解微球体的方法，该方法包括：a）制备含有至少一个聚合物相和至少一个水相的乳液，其分散聚合物相和水相之间的粘度比为0.12至10，b ）将如此获得的乳液暴露于受控的层状剪切强度，c）从聚合物相中除去溶剂，以及d）分离由此获得的微球体。 还公开了制备的微球的用途。

公开(公告)号：US20070053988A1

公开(公告)日：2007-03-08

申请号：US10575449

申请日：2004-09-30

申请人： Audrey Royere ,  Jerome Bibette ,  Didier Bazile

发明人： Audrey Royere ,  Jerome Bibette ,  Didier Bazile

IPC分类号： A61K9/14

CPC分类号： A61K9/113 ,  A61K9/107 ,  A61K47/44

摘要： A composition includes a monodispersed lipid phase which is dispersed in a continuous aqueous phase, wherein the lipid phase includes at least one crystallizable lipid, at least one active ingredient and at least one compound including two chains of fatty acids and one glycol polyethylene chain. A method for the preparation of the compositions via a simple monodispersed O/W or O/W/O double emulsion is also disclosed.

摘要翻译： 组合物包括分散在连续水相中的单分散脂质相，其中所述脂质相包含至少一种可结晶脂质，至少一种活性成分和至少一种包含两条脂肪酸链和一个二醇聚乙烯链的化合物。 还公开了通过简单的单分散O / W或O / W / O双重乳液制备组合物的方法。

公开(公告)号：US10300006B2

公开(公告)日：2019-05-28

申请号：US14003527

申请日：2012-03-07

申请人： Mathieu Goutayer ,  Jerome Bibette

发明人： Mathieu Goutayer ,  Jerome Bibette

IPC分类号： A61K8/81 ,  A61K8/891 ,  A23D7/005 ,  A23D7/02 ,  A61K8/06 ,  A61K8/11 ,  A61K8/31 ,  A61K8/92 ,  A61Q19/00 ,  B01J13/10 ,  A61K47/32 ,  A61K9/10 ,  A61K9/50 ,  A23P10/30 ,  A61K47/34

摘要： This method includes the provision of a first fluid (36) including the first phase and a first precursor polymer of the coacervate contained in the first phase, and the formation of drops of the first fluid (36) in a second fluid (40) intended to form the second phase (16). It includes the steps of introducing a second precursor polymer of the coacervate into the second fluid (40) and, during the formation of each drop (12), or once each drop (12) has been formed, for generating the coacervate layer by interaction between the first precursor polymer and the second precursor polymer at the interface between the first phase (14) and the second phase (16).

公开(公告)号：US09925504B2

公开(公告)日：2018-03-27

申请号：US11643151

申请日：2006-12-20

申请人： Andrew Griffiths ,  David Weitz ,  Keunho Ahn ,  Darren Link ,  Jerome Bibette

发明人： Andrew Griffiths ,  David Weitz ,  Keunho Ahn ,  Darren Link ,  Jerome Bibette

IPC分类号： C12Q1/68 ,  B01F13/00 ,  B01F5/06 ,  B01J19/00 ,  B01L3/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/04 ,  B01F3/08 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N35/10

CPC分类号： B01F13/0071 ,  B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5025 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N2035/1034

摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

公开(公告)号：US10107801B2

公开(公告)日：2018-10-23

申请号：US14775886

申请日：2014-03-11

申请人： HORIBA ABX SAS ,  Jerome Bibette

发明人： Aurelien Daynes ,  Gilles Cauet ,  Jean-Philippe Gineys ,  Philippe Nerin ,  Jerome Bibette

IPC分类号： G01N33/537 ,  G01N33/558 ,  G01N33/543 ,  G01N33/569

摘要： The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.

公开(公告)号：US20130178368A1

公开(公告)日：2013-07-11

申请号：US13705833

申请日：2012-12-05

申请人： Andrew David Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

发明人： Andrew David Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC分类号： C12N15/10

CPC分类号： B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00657 ,  B01J2219/00722 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12N15/1058 ,  C12N15/1075 ,  C12P21/00 ,  C12Q1/6874 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/149

摘要： The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

公开(公告)号：US20110201695A1

公开(公告)日：2011-08-18

申请号：US13058850

申请日：2009-08-14

申请人： Veronique Mourier-Robert ,  Jerome Bibette ,  Mathieu Goutayer ,  Fabrice Navarro y Garcia ,  Isabelle Texier-Nogues

发明人： Veronique Mourier-Robert ,  Jerome Bibette ,  Mathieu Goutayer ,  Fabrice Navarro y Garcia ,  Isabelle Texier-Nogues

IPC分类号： A61K47/44

CPC分类号： A61K9/0019 ,  A61K9/1075 ,  A61K41/0071 ,  A61K47/6907 ,  B82Y5/00

摘要： The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant.The invention also relates to a preparation method and use of this formulation.

摘要翻译： 本发明涉及纳米乳液形式的治疗剂制剂，其包含连续的水相和至少一种分散的油相，其中所述油相还包含所述治疗剂，至少一种两亲性脂质和 至少一种增溶脂质，其中水相包含至少一种聚烷氧化辅助表面活性剂。 本发明还涉及该制剂的制备方法和用途。

公开(公告)号：US20070092914A1

公开(公告)日：2007-04-26

申请号：US11633849

申请日：2006-12-04

申请人： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

发明人： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC分类号： C40B40/04

CPC分类号： G01N33/5432 ,  B01F3/0807 ,  B01F5/0256 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0062 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2003/0834 ,  B01F2003/0842 ,  B01J19/0046 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00657 ,  B01J2219/00664 ,  B01J2219/00666 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12Q1/42 ,  C12Q2563/159 ,  C12Q2565/119 ,  C40B50/08 ,  G01N15/14 ,  G01N21/6428 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/573 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

摘要翻译： 本发明描述了用于鉴定与生物化学体系的靶组分结合或调节靶的活性的化合物的方法，包括以下步骤：a）将化合物与靶一起分隔成微胶囊，使得只有子集 在任何一个微胶囊中以多份拷贝表示; 和b）鉴定结合或调节靶标活性的化合物; 其中在微流控制下进行至少一个步骤。 本发明能够筛选可用作药物开发潜力的大分子谱系。

公开(公告)号：US20060078893A1

公开(公告)日：2006-04-13

申请号：US10962952

申请日：2004-10-12

申请人： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

发明人： Andrew Griffiths ,  David Weitz ,  Darren Link ,  Keunho Ahn ,  Jerome Bibette

IPC分类号： C40B40/08 ,  C40B40/10 ,  C40B50/04

CPC分类号： C40B40/08 ,  B01F3/0807 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0071 ,  B01F13/0076 ,  B01J13/025 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y10/00 ,  B82Y30/00 ,  C07K1/047 ,  C12N15/1096 ,  C12Q2600/16 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N2035/1034 ,  H05K999/99

摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

公开(公告)号：US10710045B2

公开(公告)日：2020-07-14

申请号：US14375612

申请日：2013-01-31

申请人： Jerome Bibette ,  Nicolas Atrux-Tallau ,  Hugo Domejean ,  Anette Funfak ,  Nicolas Bremond ,  Pierre Nassoy ,  Kevin Alessandri

发明人： Jerome Bibette ,  Nicolas Atrux-Tallau ,  Hugo Domejean ,  Anette Funfak ,  Nicolas Bremond ,  Pierre Nassoy ,  Kevin Alessandri

IPC分类号： G01N33/50 ,  B01J13/22 ,  B01J13/08 ,  B01J13/10

摘要： A capsule containing at least one mammalian cell, includes a liquid core, and at least one external envelope totally encapsulating the liquid core at its periphery, the external envelope including at least one gelled polyelectrolyte and/or a stiffened biopolymer and being able to retain the liquid core when the capsule is immersed in a gas. The present invention further relates to the method for preparing such a capsule, to a method for screening cosmetic active ingredients as well as a culture method using such capsules.