Patent search ap:("Dale J. Kempf") AND inv:"Dale J. Kempf" Page 1

1.

发明授权
HIV protease inhibiting compounds 有权
Title translation: HIV蛋白酶抑制化合物

公开(公告)号：US08653141B2

公开(公告)日：2014-02-18

申请号：US13451370

申请日：2012-04-19

Applicant: Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao

Inventor： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao

IPC: A61K31/18 , C07D307/00

CPC classification number: C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

2.

发明授权
HIV protease inhibiting compounds 有权

公开(公告)号：US07834043B2

公开(公告)日：2010-11-16

申请号：US11008713

申请日：2004-12-09

Applicant: David A. DeGoey , Charles A. Flentge , William J. Flosi , David J. Grampovnik , Dale J. Kempf , Larry L. Klein , Ming C. Yeung , John T. Randolph , Xiu C. Wang , Su Yu

Inventor： David A. DeGoey , Charles A. Flentge , William J. Flosi , David J. Grampovnik , Dale J. Kempf , Larry L. Klein , Ming C. Yeung , John T. Randolph , Xiu C. Wang , Su Yu

IPC: A01N43/50

CPC classification number: C07D213/56 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/444 , A61K45/06 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07F9/58 , C07F9/65515 , C07F9/65583 , C07K5/0207

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

3.

发明申请
Anti-Viral Compounds 有权
Title translation: 抗病毒化合物

公开(公告)号：US20100256139A1

公开(公告)日：2010-10-07

申请号：US12817808

申请日：2010-06-17

Applicant: Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V.L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu

Inventor： Todd W. Rockway , David A. Betebenner , Allan C. Krueger , Nobuhiko Iwasaki , Curt S. Cooper , David D. Anderson , Dale J. Kempf , Darold L. Madigan , Christopher E. Motter , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V.L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu

IPC: A61K31/5377 , C07D471/04 , A61K31/444 , A61P31/14

CPC classification number: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

4.

发明授权
Neuraminidase inhibitors 失效
Title translation: 神经氨酸酶抑制剂

公开(公告)号：US06593314B1

公开(公告)日：2003-07-15

申请号：US09668245

申请日：2000-09-22

Applicant: Clarence J. Maring , Vincent L. Giranda , Yu Gui Gu , Stephen Hanessian , Dale J. Kempf , Darold L. Madigan , Kent Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Jianchio Wang , Chen Zhao

Inventor： Clarence J. Maring , Vincent L. Giranda , Yu Gui Gu , Stephen Hanessian , Dale J. Kempf , Darold L. Madigan , Kent Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Jianchio Wang , Chen Zhao

IPC: A61K31655

CPC classification number: C07C233/52 , C07C247/12 , C07C2601/16 , C07D303/38 , C07D303/40

Abstract: The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.

Abstract translation: 本发明提供了可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶的药学上可接受的盐，前药或酯的式Ia化合物和Ibor，其含有其的药物制剂，用于制备所述化合物的方法和中间体以及使用所述化合物的方法，包括预防和治疗由具有所述神经氨酸酶的微生物引起的疾病。